scholarly journals Mesenchymal stem cell-derived inflammatory fibroblasts mediate interstitial fibrosis in the aging heart

2016 ◽  
Vol 91 ◽  
pp. 28-34 ◽  
Author(s):  
JoAnn Trial ◽  
Mark L. Entman ◽  
Katarzyna A. Cieslik
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Interstitial Fibrosis ◽  
Aging Heart

scholarly journals Mesenchymal stem cell–derived exosomal microRNA-34c-5p ameliorates renal pericyte activation by inhibiting core fucosylation

2020 ◽  
Author(s):  
Hu Xuemei ◽  
Nan Shen ◽  
Anqi Liu ◽  
Weidong Wang ◽  
Lihua Zhang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Interstitial Fibrosis ◽  
Kidney Diseases ◽  
Post Translational Modification ◽  
Microvascular Damage ◽  
Egfr Ligand ◽  
Underlying Mechanisms ◽  
Signaling Activation ◽  
Core Fucosylation

Abstract Renal interstitial fibrosis (RIF) is an incurable pathological lesion in progressive chronic kidney diseases. Myofibroblast proliferation and microvascular damage are two important events in RIF, and pericytes are a major source of myofibroblasts in the kidney. However, the underlying mechanisms remain poorly characterized. We report that core fucosylation (CF), a post-translational modification of proteins, is essential for pericyte activation by regulating profibrotic and antifibrotic signaling pathways as a “hub-like” target. Mesenchymal stem cell (MSC)-derived exosomes reside specifically in the obstructed kidney and deliver microRNA (miR)-34c-5p to inhibit CF, reducing pericyte activation and renal fibrosis. Furthermore, we clarify that the CD81–EGFR ligand–receptor complex aids the entry of exosomal miR-34c-5p into pericytes. Our results reveal a novel mechanism of pericyte activation based on CF and suggest a potential use of MSC exosomes as a new therapeutic strategy for RIF by inhibiting CF, the hub-like target of profibrotic signaling activation.

scholarly journals Mesenchymal Stem Cell Therapy Prevents Interstitial Fibrosis and Tubular Atrophy in a Rat Kidney Allograft Model

2012 ◽  
Vol 21 (17) ◽  
pp. 3125-3135 ◽  
Author(s):  
Marcella Franquesa ◽  
Esther Herrero ◽  
Joan Torras ◽  
Elia Ripoll ◽  
Maria Flaquer ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Interstitial Fibrosis ◽  
Rat Kidney ◽  
Tubular Atrophy ◽  
Kidney Allograft ◽  
Mesenchymal Stem Cell Therapy
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