Observations on the effect of house dust potencies

1981 ◽  
Vol 70 (02) ◽  
pp. 70-87 ◽  
Author(s):  
R.M. Morris-Owen ◽  
K. Datt-Lai

SummaryA short term study of the effect of House-dust potencies (30, 200) has been made in seventy-nine nasal or naso-bronchial patients with some degree of irritable reaction to inhaled house dust.Sixty-two firm assessments of the initial treatments were made: in twenty-three there was clearly no effect, twenty-eight showed remissions of varying tempo and duration: in seven of these there were associated ‘reactive’ features. Eleven showed only symptomatic effects which might be considered as “reactive” or as “proving” manifestations.Detail is given of the further course of those who began with remission, and of the symptoms encountered in the aggravations. Immunity to the effects of dust inhalation was an outstanding feature of the remissions, which however generally covered the whole symptomatic behaviour as well.Only six patients have so far appeared capable of long-term response to treatment with House dust potencies alone.The effects are compared with those of house dust injections, and it is clearly indicated that the two treatments operate on different lines.Tentative suggestions are made for the discrimination of patients who may respond to the potencies and for the bearing these observations have on the design of a controlled trial.

1992 ◽  
Vol 29 (6) ◽  
pp. 521-527 ◽  
Author(s):  
J. S. Cullor ◽  
W. Smith ◽  
J. G. Zinkl ◽  
J. D. Dellinger ◽  
T. Boone

Colony-stimulating factors are a category of glycoproteins that are instrumental in the regulation of hematopoiesis and inflammation. This investigation documented the clinical bone marrow and peripheral blood responses to short-term and long-term administration of a recombinant bovine granulocyte colony-stimulating factor (rb-GCSF) and an analog, where the cysteine at position 17 was substituted with a serine (rb-GCSF ser17). The colony-stimulating factors produced the expected changes in the hematologic findings of the bovine subjects in the study, and there was a cell-specific response to the compounds. The sustained neutrophilia in the long-term study indicates that the bovine species can tolerate the administration of recombinant forms of bovine GCSF for extended periods of time without detectable adverse side effects. The neutrophils from the short-term study revealed no apparent fluctuation, either as enhanced or reduced capability to reduce nitro blue tetrazolium as compared to pretreatment neutrophils. The administration of both recombinant forms of GCSF produced large increases in the bone marrow myeloid: erythroid (M:E) ratio concomitantly with the neutrophilias. This is the first preliminary report documenting the bone marrow response of cattle to the native and recombinant (rb-GCSF ser17) forms of bovine GCSF.


1971 ◽  
Vol 24 (3) ◽  
pp. 325-340 ◽  
Author(s):  
J. H. Beattie

At the end of February 1971 an exploratory survey of marine traffic on the English side of the Dover Strait was organized and conducted by the National Physical Laboratory of the Department of Trade and Industry. The aim of this first short-term study was to examine possible methods for the long term, and the basic radar ship count was carried out by Decca Radar on behalf of the N.P.L. This trial took place over 72 hours between 12.00 hours on Friday, 26 February and 12.00 hours on Monday, 1 March 1971, all times G.M.T.; it showed that further flow data in other areas of the Strait would be of value and Decca Radar decided to gather additional limited data on traffic flow. The most urgent appeared to be at the narrowest part of the Strait between Cap Gris Nez and Folkestone where the Greek M.V. Niki sank off the Varne during the trial at 20.00 G.M.T. on Saturday, 27 February.


2016 ◽  
Vol 38 (1) ◽  
pp. 104-118 ◽  
Author(s):  
Tina M. Kruger ◽  
Sarah Gilland ◽  
Jacquelyn B. Frank ◽  
Bridget C. Murphy ◽  
Courtney English ◽  
...  

1989 ◽  
Vol 113 (3) ◽  
pp. 401-406 ◽  
Author(s):  
G. B. Robbins ◽  
J. J. Bushell ◽  
G. M. McKeon

SUMMARYThe extent and rate of N release from nylon bags containing green panic (Panicum maximumvar.trichoglume)litter was measured for up to 319 days (long-term studies) in 1978/79 and 1979/80 in Gayndah, Australia. Dry matter (DM) decomposition rates were measured in 41 periods of 39 days and related to environmental variables and initial litter N concentrations (short-term study).About half of litter DM decomposed during the long-term studies, while N concentration in the remaining litter increased from an initial average of 0–57 % N, to 0–95 % N. Net release of N from bags began when its concentration in the residue increased to c.0–65% N (or when the C:N ratio decreased to 75:1). Only a net 20–30 % of the initial N was released for potential plant uptake by the end of the study. The short-term study showed that DM decomposition was rapid and independent of pasture age. Decomposition rate increased with soil moisture and average daily temperature but was unaffected by initial litter N concentration. Release of N from decomposing litter was slow, despite rapid DM decomposition. It was concluded that a major cause of declining productivity in sown grass pastures is the immobilization of N in decomposing grass litter.


2017 ◽  
Author(s):  
◽  
Laura Streeter

Cultural competency is a crucial component of baccalaureate nursing education to support patient-centered practice (Calvillo, Clark, Ballantyne, Pacquiao, Purnell, and Villarruel 2009). Studying abroad is associated with short-term gains in students' cultural competency; however, little research has addressed whether cultural competence is affected long-term, particularly when the study abroad experience is relatively short (Phillips, Bloom, Gainey, and Chiocca, in press). Therefore, the question that drove this study was: what are the long-term effects of a short-term study abroad experience on baccalaureate nursing students? The participants in this study were practicing nurses (N=21) who had traveled to Ghana for two-week study abroad experiences as senior nursing students between 2011 and 2015. Qualitative data (collected immediately post-travel) with these participants revealed four key themes of transformation consistent with cultural transformation: adaptability, cultural competency, understanding of social determinants of health, and mutual partnerships with patients. Social media was used to enroll participants in a study conducted over a one-month period in fall 2016. Of the 45 contacted, 28 responded and consented to participate and 21 completed data collection. A series of Likert-style questions (5=Strongly Agree, 1=Strongly Disagree) were used to measure these nurses' perceived immediate post-travel change, versus their perceptions of the sustained changes over time. Results supported that the four key themes of cultural transformation persisted over time. Creating mutual partnerships and understanding social determinants of health had the highest mean score and lowest standard deviation (mean= 4.76, standard deviation= 0.44)


Hypertension ◽  
2019 ◽  
Vol 74 (6) ◽  
pp. 1551-1562 ◽  
Author(s):  
Chang Li ◽  
Xiaole Yan ◽  
Danyu Wu ◽  
Kai Zhang ◽  
Xin Liang ◽  
...  

The α1-AR (α1 adrenergic receptor) blockers currently on the market cannot meet clinical needs because of low-selectivity for subtypes of α1-ARs, short half-life, and uncertain role in cardiovascular end point events. The study sought to find a vaccine specifically against α1D-AR (α1D-adrenergic receptor) for treating hypertension. A short peptide ADR-004 (cgiteeagy) belonging to α1D-AR was screened, and the ADRQβ-004 vaccine was produced and injected into spontaneously hypertensive rats model (including a short-term study, 10 weeks, and a long-term observation study, 39 weeks) and NG-nitro- l -arginine methyl ester + spontaneously hypertensive rats model (15 weeks). The antihypertensive effect and target organ protection of the ADRQβ-004 vaccine were carefully evaluated. The possible immune-mediated damage was detected in normal vaccinated Sprague Dawley rats. The ADR-004 peptide has perfect immunogenicity, and the ADRQβ-004 vaccine could induce strong antibody production. In the short-term study, the ADRQβ-004 vaccine averagely decreased the systolic blood pressure of spontaneously hypertensive rats up to 15 mm Hg and that of NG-nitro- l -arginine methyl ester+spontaneously hypertensive rats up to 29 mm Hg. In the long-term observation model, the antihypertensive effect of the ADRQβ-004 vaccine was quite stable, and the average decline of systolic blood pressure was 22 mm Hg. The ADRQβ-004 vaccine effectively prevented vascular structural remodeling, cardiac hypertrophy and fibrosis, and renal injury of hypertensive animals, superior to prazosin at renal level. Moreover, the ADRQβ-004 vaccine obviously downregulated the expression of α1D-AR, but not α1A-AR. Additionally, no significant immune-mediated damage was detected in immunized animals. The present results demonstrate that the ADRQβ-004 vaccine may provide a novel and promising method for the treatment of hypertension.


2007 ◽  
Vol 13 (1) ◽  
pp. 39-51 ◽  
Author(s):  
Susan C. Mapp ◽  
Peggy McFarland ◽  
Elizabeth A. Newell

The purpose of this study was to discover if short-term study abroad trips produce the same changes in students that have been documented in long-term study abroad trips. The study was conducted with current and past participants of a short-term study abroad trip to Ireland from a small liberal arts school. Quantitative and qualitative assessment tools were used to address the question. Results found that change was supported by the qualitative, but not the quantitative, assessment. Students reported the trip increased their cross-cultural awareness and their interest in a long-term study abroad experience. As these results support the hypothesis that short-term study abroad experiences have a positive effect on students' growth, it is important that programs develop and facilitate such opportunities for their students. Not only will this improve the global awareness and cultural competence of participants, but it will increase participation in long-term study abroad programs.


2019 ◽  
Vol 8 (4) ◽  
pp. 18 ◽  
Author(s):  
Todd M. Vanden Berg ◽  
Lissa Schwander

This paper explores the long-term impact of a short-term study abroad program on alumni of the program years after having taken the course. Through using a mixed measure survey, the data reveals that short-term study abroad programs can have a significant and direct impact on the lives of alumni. The specific program considered has impacted alumni choices of international tourist destinations, activities alumni participate in while traveling abroad, as well as the choices alumni make concerning lodging while traveling abroad. In short, after participating in a short-term study abroad program, alumni have developed a global citizenship identity.


2015 ◽  
Vol 26 (1) ◽  
pp. 107-120 ◽  
Author(s):  
James Shiveley ◽  
Thomas Misco

Given the calls for a stronger global focus among pre-service teachers and the value of study abroad experiences to assist in this process, many teacher preparation programs have worked to include study abroad experiences into their programs. Including study abroad experiences lasting a semester or more has proven to be a challenge for many such programs however, given the highly structured and locally contextual nature of teacher education. The result is that most study abroad experiences available for preservice teachers are short-term, lasting only a few weeks. The purpose of this study was to determine whether or not a short-term study abroad course, taken during preservice teachers’ undergraduate program, had any lasting professional or personal impact once they become teachers.


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