Von Willebrand factor and assessment of endothelial function

A study of daily blood pressure (BP) dynamics, functional endothelial condition at hypertensive patients in combination with tuberculosis of various localization and estimation of an opportunity of correction of the revealed disturbances during 12-week therapy by the fixed combination of perindopril and indapamide - noliprel-forte (Servier, France) were performed. During research more expressed endothelial dysfunction at hypertensive patients, proceeding on a background of tubercular process in comparison with patients with isolated arterial hypertension was revealed. Therapy by noliprel-forte provided the reliable 24-hour control of BP level, which was accompanied by endothelial function normalization that was shown by improvement of a endothelium-dependent vasodilatation and decrease of a von Willebrand factor level. .

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Von Willebrand Factor Multimers and the Relaxation Response: A One-Year Study

Entropy ◽

10.3390/e23040447 ◽

2021 ◽

Vol 23 (4) ◽

pp. 447

Author(s):

Carlo Dal Lin ◽

Laura Acquasaliente ◽

Sabino Iliceto ◽

Vincenzo De Filippis ◽

Giuseppe Vitiello ◽

...

Keyword(s):

Endothelial Function ◽

Von Willebrand Factor ◽

Quaternary Structure ◽

Regulatory Element ◽

Protein Carbonyl ◽

Relaxation Response ◽

Study Results ◽

One Year ◽

Von Willebrand ◽

Willebrand Factor

Background and aim: Mental stress represents a pivotal factor in cardiovascular diseases. The mechanism by which stress produces its deleterious ischemic effects is still under study but some of the most explored pathways are inflammation, endothelial function and balancing of the thrombotic state. In this scenario, von Willebrand factor (vWF) is a plasma glycoprotein best known for its crucial hemostatic role, also acting as key regulatory element of inflammation, being released by the activated vascular endothelium. Antistress techniques seem to be able to slow down inflammation. As we have recently verified how the practice of the Relaxation Response (RR), which counteracts psychological stress, causes favorable changes in some inflammatory genes’ expressions, neurotransmitters, hormones, cytokines and inflammatory circulating microRNAs with coronary endothelial function improvement, we aimed to verify a possible change even in serum levels of vWF. Experimental procedure: We measured vWF multimers and the total protein carbonyl contents in the sera of 90 patients with ischemic heart disease (and 30 healthy controls) immediately before and after an RR session, three times (baseline, 6 months, 12 months), during a one-year follow-up study. Results: According to our data, large vWF multimers decrease during the RR, as does the plasma total carbonyl content. Conclusion: vWF levels seem to vary rapidly between anti-inflammatory and antithrombotic behaviors dependent on psychological activity, leading to relaxation and also possibly changes in its quaternary structure.

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von Willebrand Factor Inhibition Improves Endothelial Function in Patients with Stable Angina

Journal of Cardiovascular Translational Research ◽

10.1007/s12265-012-9422-3 ◽

2012 ◽

Vol 6 (3) ◽

pp. 364-370 ◽

Cited By ~ 18

Author(s):

Olivier Muller ◽

Jozef Bartunek ◽

Michalis Hamilos ◽

Catalina Trana Berza ◽

Fabio Mangiacapra ◽

...

Keyword(s):

Endothelial Function ◽

Von Willebrand Factor ◽

Stable Angina ◽

Von Willebrand ◽

Willebrand Factor

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Serum concentrations of von Willebrand factor and soluble thrombomodulin indicate alteration of endothelial function in inflammatory bowel diseases

Digestive Diseases and Sciences ◽

10.1007/bf02064981 ◽

1995 ◽

Vol 40 (4) ◽

pp. 793-799 ◽

Cited By ~ 13

Author(s):

A. M. Sawyerr ◽

M. S. Smith ◽

A. Hall ◽

M. Hudson ◽

C. R. Hay ◽

...

Keyword(s):

Endothelial Function ◽

Von Willebrand Factor ◽

Inflammatory Bowel Diseases ◽

Serum Concentrations ◽

Soluble Thrombomodulin ◽

Bowel Diseases ◽

Inflammatory Bowel ◽

Von Willebrand ◽

Willebrand Factor

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Endothelial Function and Coagulant Factors in Growth Hormone-Treated Hypopituitary Adults Receiving Desmopressin

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2002-021618 ◽

2003 ◽

Vol 88 (5) ◽

pp. 2152-2156 ◽

Cited By ~ 3

Author(s):

J. C. Smith ◽

H. A. Lane ◽

J. Lewis ◽

S. Dann ◽

J. Goodfellow ◽

...

Keyword(s):

Endothelial Function ◽

Factor Viii ◽

Von Willebrand Factor ◽

Control Group ◽

Flow Mediated Dilation ◽

Clotting Factors ◽

Von Willebrand Factor Antigen ◽

Von Willebrand ◽

Willebrand Factor ◽

Factor Antigen

Although GH deficiency may underlie the increased cardiovascular risk in adult hypopituitarism, other coexisting hormonal deficiencies and/or unphysiological hormone replacement may contribute. l-Deamino-8-d-arginine (DDAVP), when administered parenterally, potentiates hemostasis by increasing plasma procoagulant factors. We investigated whether chronic intranasal DDAVP therapy influences clotting factors (plasma fibrinogen, factor VIII, and von Willebrand factor antigen) and endothelial function (flow-mediated dilation of the brachial artery) in 30 GH-treated hypopituitary subjects, including both DDAVP-treated subjects (group A) (mean age, 46 ± 11 yr) and vasopressin-sufficient subjects (group B) (mean age, 47 ± 16 yr). Fifteen healthy controls (group C) (mean age, 48 ± 12 yr) were also studied. All hypopituitary patients were receiving stable GH replacement (median duration, 19 months). Comparing the three groups, concentrations of fibrinogen (mean ± sd) (A, 3.3 ± 1.0 g/liter vs. B, 3.5 ± 0.9 vs. C, 2.6 ± 0.8, P < 0.05), factor VIII (A, 130% ± 30% vs. B, 128% ± 30% vs. C, 104% ± 35%, P < 0.05) and von Willebrand factor antigen (A, 124% ± 35% vs. B, 134% ± 45% vs. C, 93% ± 36%, P < 0.05) were higher in hypopituitary subjects, compared with controls. However, there were no differences in clotting factors between groups A and B. Flow-mediated dilation did not differ significantly between the two hypopituitary groups (A, 5.9% ± 2.0% vs. B, 4.7% ± 1.6%) and was similar to that in the control group (C, 5.7% ± 2.1%). In conclusion, although endothelium-dependent vasodilation is intact in GH-treated hypopituitary adults, elevated concentrations of hemostatic markers suggest the persistence of a prothrombotic tendency and endothelial dysfunction. Intranasal DDAVP does not appear to influence this proatherogenic profile in hypopituitary adults with vasopressin deficiency.

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Plasma Homocysteine Is Weakly Correlated with Plasma Endothelin and von Willebrand Factor but not with Endothelium-dependent Vasodilatation in Healthy Postmenopausal Women

Clinical Chemistry ◽

10.1093/clinchem/45.8.1200 ◽

1999 ◽

Vol 45 (8) ◽

pp. 1200-1205 ◽

Cited By ~ 6

Author(s):

Gerdien W de Valk-de Roo ◽

Coen DA Stehouwer ◽

Jan Lambert ◽

Casper G Schalkwijk ◽

Marius J van der Mooren ◽

...

Keyword(s):

Endothelial Function ◽

Postmenopausal Women ◽

Von Willebrand Factor ◽

Plasma Concentrations ◽

Plasminogen Activator Inhibitor ◽

Plasma Homocysteine ◽

Cardiovascular Morbidity And Mortality ◽

Von Willebrand ◽

Willebrand Factor ◽

Pai 1

Abstract Background: Hyperhomocysteinemia is an independent cardiovascular risk factor, possibly through the induction of endothelial dysfunction. The postmenopausal state is associated with increased plasma homocysteine. We examined whether increased homocysteine is associated with impaired endothelial function. Methods: Sixty-three hysterectomized but otherwise healthy postmenopausal women (54.8 ± 3.5 years) participated in this study. Fasting total plasma homocysteine (tHcy) was measured as free plus protein-bound homocysteine. Endothelial function was assessed by measuring plasma concentrations of the endothelium-derived proteins endothelin (ET), von Willebrand factor (vWF), and plasminogen activator inhibitor type 1 (PAI-1) as well as brachial artery flow-mediated, endothelium-dependent vasodilatation (FMD). Results: Plasma tHcy was 9.6 ± 2.5 μmol/L. After adjustment for possible confounders, a 1 μmol/L increase in tHcy was associated with an increase in ET of 0.08 ng/L (P = 0.045) and an increase in vWF of 4.2% (P = 0.05). No statistically significant association was present between tHcy and PAI-1 or FMD. Conclusions: Increased fasting homocysteine in postmenopausal women may impair some aspects of endothelial function. It is of clinical interest to study whether homocysteine lowering can improve endothelial function and thus cardiovascular morbidity and mortality in postmenopausal women.

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