S1789 Altered Jejunal Tight Junction Signalling Correlates With Mucosal Mast Cell Activation and Symptom Severity in Diarrhea-Prone Irritable Bowel Syndrome Patients

2010 ◽  
Vol 138 (5) ◽  
pp. S-274
Author(s):  
Cristina Martinez ◽  
Maria Vicario ◽  
Beatriz Lobo ◽  
Laura Ramos ◽  
Carmen Alonso ◽  
...  
Keyword(s):  
Mast Cell ◽  
Irritable Bowel Syndrome ◽  
Tight Junction ◽  
Symptom Severity ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Mucosal Mast Cell ◽  
Irritable Bowel

scholarly journals The Effect of Tong-Xie-Yao-Fang on Intestinal Mucosal Mast Cells in Postinfectious Irritable Bowel Syndrome Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Xiangxue Ma ◽  
Xiaoge Wang ◽  
Nan Kang ◽  
Ting Chen ◽  
Haijie Ji ◽  
...  
Keyword(s):  
Mast Cell ◽  
Irritable Bowel Syndrome ◽  
Mast Cells ◽  
Intestinal Mucosa ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Mucosal Mast Cells ◽  
Fos Expression ◽  
Irritable Bowel ◽  
Postinfectious Irritable Bowel Syndrome

Objective. To investigate the effects of Tong-Xie-Yao-Fang (TXYF) on intestinal mucosal mast cells in rats with postinfectious irritable bowel syndrome (PI-IBS).Design. PI-IBS rat models were established using a multistimulation paradigm. Then, rats were treated with TXYF intragastrically at doses of 2.5, 5.0, and 10.0 g·kg−1·d−1for 14 days, respectively. Intestinal sensitivity was assessed based on abdominal withdrawal reflex (AWR) scores and fecal water content (FWC). Mast cell counts and the immunofluorescence of tryptase and c-Fos in intestinal mucosa were measured; and serum IL-1β, TNF-α, and histamine levels were determined.Results. AWR reactivity and FWC which were significantly increased could be observed in PI-IBS rats. Remarkably increased mast cell activation ratio in intestinal mucosa, together with increased serum TNF-αand histamine levels, could also be seen in PI-IBS rats; furthermore, PI-IBS-induced changes in mast cell activation and level of serum TNF-αand histamine could be reversed by TXYF treatment. Meanwhile, tryptase and c-Fos expression were also downregulated.Conclusion. TXYF improves PI-IBS symptoms by alleviating behavioral hyperalgesia and antidiarrhea, the underlying mechanism of which involves the inhibitory effects of TXYF on activating mucosal mast cells, downregulating tryptase and c-Fos expression, and reducing serum TNF-αand histamine levels.

scholarly journals Impact of Diet on Symptoms of the Irritable Bowel Syndrome

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 575
Author(s):  
Robin Spiller
Keyword(s):  
Mast Cell ◽  
Irritable Bowel Syndrome ◽  
Cell Activation ◽  
Personalised Medicine ◽  
Short Chain Fatty Acids ◽  
Mast Cell Activation ◽  
Bowel Habit ◽  
Gaseous Distension ◽  
Typical Food ◽  
Irritable Bowel

Irritable bowel syndrome (IBS), with its key features of abdominal pain and disturbed bowel habit, is thought by both patients and clinicians to be strongly influenced by diet. However, the complexities of diet have made identifying specific food intolerances difficult. Eating disorders can masquerade as IBS and may need specialist treatment. While typical food allergy is readily distinguished from IBS, the mechanisms of gut-specific adverse reactions to food are only just being defined. These may include gut-specific mast cell activation as well as non-specific activation by stressors and certain foods. Visceral hypersensitivity, in some cases mediated by mast cell activation, plays a key part in making otherwise innocuous gut stimuli painful. Rapidly fermented poorly absorbed carbohydrates produce gaseous distension as well as short-chain fatty acids and lowering of colonic pH which may cause symptoms in IBS patients. Limiting intake of these in low FODMAP and related diets has proven popular and apparently successful in many patients. Existing diet, colonic microbiota and their metabolic products may be helpful in predicting who will respond. Wheat intolerance may reflect the fact that wheat is often a major source of dietary FODMAPs. It may also be either a forme fruste of coeliac disease or non-specific immune activation. Wheat exclusion can be successful in some of these patients. More research is needed to fully understand the mechanisms of food intolerances and how to best ameliorate them in a personalised medicine approach to diet in IBS.

Evidence for Mast Cell Activation in Patients with Therapy-Resistant Irritable Bowel Syndrome

2011 ◽  
Vol 49 (02) ◽  
pp. 191-194 ◽  
Author(s):  
T. Frieling ◽  
K. Meis ◽  
U. Kolck ◽  
J. Homann ◽  
A. Hülsdonk ◽  
...  
Keyword(s):  
Mast Cell ◽  
Irritable Bowel Syndrome ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Irritable Bowel

Costunolide ameliorates intestinal dysfunction and depressive behaviour in mice with stress-induced irritable bowel syndrome via colonic mast cell activation and central 5-hydroxytryptamine metabolism

2021 ◽  
Author(s):  
Xi Li ◽  
Qingqing Liu ◽  
Jiaoyan Yu ◽  
Ruitao Zhang ◽  
Ting Sun ◽  
...  
Keyword(s):  
Mast Cell ◽  
Irritable Bowel Syndrome ◽  
High Risk ◽  
Bowel Disease ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Depression And Anxiety ◽  
Functional Bowel Disease ◽  
Irritable Bowel ◽  
The Brain

Irritable bowel syndrome (IBS) is a common chronic functional bowel disease, associated with a high risk of depression and anxiety. The brain–gut axis plays an important role in the pathophysiological...

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