Mo1056 Reflux Symptoms are Highly Prevalent and Impact Quality of Life of Obese Subjects Participating in a Structured Weight Loss Program

163 Background: Obesity is associated with higher breast cancer recurrence and death, and poorer health and quality of life. African-American (AA) women have the highest prevalence of obesity, obesity-related comorbidities, and breast cancer mortality compared with other racial/ethnic groups. Weight loss after breast cancer diagnosis may lower rates of recurrence and improve fitness, fatigue, and quality of life. Methods: This 6-month randomized controlled trial pilot-tests the use of a Fitbit activity tracker (Fitbit only group) versus Fitbit plus SparkPeople, a free web-based weight loss program (combined group) among 70 AA breast cancer survivors. Paired t-tests assess changes from baseline to 6-months among each participant in primary (weight, body mass index [BMI], percent body fat) and secondary (24-hour caloric intake, daily number of steps, quality of life, self-monitoring strategies, self-efficacy) outcomes. Two-group t-tests assess differences in outcomes between the two groups. Results: Currently, 36 of 46 (78.3%) eligible participants have enrolled and completed baseline assessments. Mean age of participants is 61.7 years (SD 8.7) and mean BMI is 36.9 (SD 7.0). Analyses of the first 25 participants who completed 3-month assessments (Fitbit only N = 12; combined group N = 13) show significant weight loss in both groups; Fitbit only: mean weight change -6.73 pounds, SD 4.61, p < 0.001; mean BMI change -0.96 kg/m2, SD 0.84, p = 0.002; combined group: mean weight change -5.95 pounds, SD 5.84, p = 0.003; mean BMI change -1.03 kg/m2, SD 0.77, p < 0.001. All participants significantly increased tracking of diet (Fitbit only p = 0.016; combined group p < 0.001) and physical activity (Fitbit only p < 0.001; combined group p = 0.001). Though not significant, combined group participants showed greater increases in self-efficacy for eating healthy and reducing fat and calories, and increases in daily steps (+1308 vs. +285 for Fitbit only group). Preliminary analyses show no statistically significant difference in changes in outcomes from baseline to 3 months between the two groups. Conclusions: Both programs show potential as convenient and efficient weight loss methods for African-American breast cancer survivors. Clinical trial information: NCT02699983.

Download Full-text

Multicenter evaluation of an interdisciplinary 52-week weight loss program for obesity with regard to body weight, comorbidities and quality of life—a prospective study

International Journal of Obesity ◽

10.1038/ijo.2011.107 ◽

2011 ◽

Vol 36 (4) ◽

pp. 614-624 ◽

Cited By ~ 73

Author(s):

S C Bischoff ◽

A Damms-Machado ◽

C Betz ◽

S Herpertz ◽

T Legenbauer ◽

...

Keyword(s):

Quality Of Life ◽

Weight Loss ◽

Body Weight ◽

Prospective Study ◽

Weight Loss Program ◽

A Prospective Study

Download Full-text

Effects of the Curves® fitness & weight loss program in senior‐aged women: quality of life

The FASEB Journal ◽

10.1096/fasebj.22.2_supplement.787 ◽

2008 ◽

Vol 22 (S2) ◽

pp. 787-787

Author(s):

J Hartman ◽

M Galbreath ◽

R Chandran ◽

K Beavers ◽

G Hudson ◽

...

Keyword(s):

Quality Of Life ◽

Weight Loss ◽

Weight Loss Program

Download Full-text

Feasibility of Bariatric Surgery as a Strategy for Secondary Prevention in Cardiovascular Disease: A Report from the Swedish Obese Subjects Trial

Journal of Obesity ◽

10.1155/2010/102341 ◽

2010 ◽

Vol 2010 ◽

pp. 1-6 ◽

Cited By ~ 22

Author(s):

Lotta Delling ◽

Kristjan Karason ◽

Torsten Olbers ◽

David Sjöström ◽

Björn Wahlstrand ◽

...

Keyword(s):

Quality Of Life ◽

Risk Factors ◽

Bariatric Surgery ◽

Weight Loss ◽

Cardiovascular Risk ◽

Secondary Prevention ◽

Cardiovascular Risk Factors ◽

Surgery Group ◽

Obese Subjects

Aims. Evaluation of bariatric surgery as secondary prevention in obese patients with ischemic heart disease (IHD).Methods. Analysis of data from 4047 subjects in the Swedish Obese Subjects (SOSs) study. Thirty-five patients with IHD are treated with bariatric surgery () or conventional treatment (). Mean follow-up is 10.8 years.Results. Bariatric surgery resulted in sustained weight loss during the study period. After 2 years, the surgery group displayed significant reductions in cardiovascular risk factors, relief from cardiorespiratory symptoms, increments in physical activity, and improved quality of life. After 10 years, recovery from hypertension, diabetes, physical inactivity, and depression was still more common in the surgery group. There were no signs of increased cardiovascular morbidity or mortality in the surgery group.Conclusion. Bariatric surgery appears to be a safe and feasible treatment to achieve long-term weight loss and improvement in cardiovascular risk factors, symptoms, and quality of life in obese subjects with IHD.

Download Full-text

Improved Psychological Well-Being, Quality of Life, and Health Practices in Moderately Overweight Women Participating in a 12-Week Structured Weight Loss Program

Obesity Research ◽

10.1002/j.1550-8528.1998.tb00339.x ◽

1998 ◽

Vol 6 (3) ◽

pp. 208-218 ◽

Cited By ~ 113

Author(s):

James M. Rippe ◽

Janet M. Price ◽

Stacey A. Hess ◽

Greg Kline ◽

Kimberly A. DeMers ◽

...

Keyword(s):

Quality Of Life ◽

Weight Loss ◽

Well Being ◽

Weight Loss Program ◽

Health Practices ◽

Psychological Well Being ◽

Overweight Women

Download Full-text

Weight Loss and Quality of Life Improvement in Obese Subjects Treated with Sibutramine: A Double-Blind Randomized Multicenter Study

Annals of Nutrition and Metabolism ◽

10.1159/000100824 ◽

2007 ◽

Vol 51 (1) ◽

pp. 75-81 ◽

Cited By ~ 13

Author(s):

V. Di Francesco ◽

T. Sacco ◽

M. Zamboni ◽

L. Bissoli ◽

E. Zoico ◽

...

Keyword(s):

Quality Of Life ◽

Weight Loss ◽

Multicenter Study ◽

Double Blind ◽

Life Improvement ◽

Obese Subjects

Download Full-text

Efficiency of a 15-Week Weight-Loss Program, Including a Low-Calorie Formula Diet, on Glycemic Control in Patients with Type 2 Diabetes Mellitus and Overweight or Obesity

Obesity Facts ◽

10.1159/000511453 ◽

2021 ◽

Vol 14 (1) ◽

pp. 45-55

Author(s):

Lena J. Storck ◽

Peter J. Meffert ◽

Janine Rausch ◽

Simone Gärtner ◽

Ali A. Aghdassi ◽

...

Keyword(s):

Quality Of Life ◽

Weight Loss ◽

Glycemic Control ◽

Weight Loss Program ◽

Antidiabetic Medication ◽

Short Term ◽

Formula Diet ◽

Overweight Or Obesity

Introduction: Patients who are overweight or obese have an increased risk of developing type 2 diabetes mellitus (T2DM). Weight loss can have a positive effect on glycemic control. Objective: We aimed to investigate glycemic control in patients with T2DM and overweight or obesity during a structured weight-loss program. Methods: This was a prospective, interventional study. We recruited 36 patients (14 men and 22 women) with a median age of 58.5 years and median body mass index (BMI) of 34.1, to a 15-week structured weight-loss program with a low-calorie (800 kcal) formula diet for 6 weeks. The primary end point, HbA1c level, and secondary end points, anthropometric data, medication, and safety, were assessed weekly. Laboratory values and quality of life were assessed at baseline and after 15 weeks. Results: HbA1c decreased from 7.3% at baseline to 6.5% at 15 weeks (p < 0.001), median body weight by 11.9 kg (p < 0.001), median BMI by 4.3 (p < 0.001) and median waist circumference by 11.0 cm (p < 0.001). Two participants discontinued insulin therapy, 4 could reduce their dosage of oral antidiabetic agents, and 6 completely discontinued their antidiabetic medication. Insulin dose decreased from 0.63 (0.38–0.89) to 0.39 (0.15–0.70) units/kg body weight (p < 0.001). No patient experienced hypoglycemic episodes or hospital emergency visits. Triglycerides and total cholesterol decreased as well as surrogate markers of liver function. However, the levels of high-density and low-density lipoprotein cholesterol (HDL-C and LDL-C) as well as uric acid remain unchanged. Regarding quality of life, the median physical health score increased from 44.5 (39.7–51.4) at baseline to 48.0 (43.1–55.3; p = 0.007), and the median mental health score decreased from 42.1 (36.1–46.7) to 37.4 (30.3–43.7; p = 0.004). Conclusions: A structured weight-loss program is effective in the short term in reducing HbA1c, weight, and antidiabetic medication in patients with T2DM who are overweight or obese. Levels of HDL-C and LDL-C were not affected by short-term weight loss. The decline in mental health and the long-term effects of improved glycemic control require further trials.

Download Full-text