Su1217 - Estimation of the Degree of Gastric Mucosal Atrophy before H. Pylori Eradication Based on Serum Pepsinogen after Eradication

Abstract Background Serum pepsinogen (PG) levels correlate with the degree of gastric mucosal inflammation and atrophy, which correlate with gastric cancer risk, in patients infected with Helicobacter pylori (H. pylori). Serum PG levels change after eradication of H. pylori, but it is not known if there are corresponding changes in the gastric mucosa. We examined whether the degree of gastric atrophy correlated with PG levels measured after eradication of H. pylori. Methods We retrospectively examined the relationship between gastric atrophy and serum levels of PG I, PG II and PG I/II ratios measured after eradication of H. pylori. The degree of gastric mucosal atrophy before H. pylori eradication was scored (0, 1, 2) according to the Kyoto classification of gastritis. Results A total of 430 treated patients were enrolled. Serum levels of PG I (ρ = − 0.362 and P < 0.001), PG II (ρ = − 0.158 and P = 0.001) and PG I/II ratio (ρ = − 0.337 and P < 0.001) all correlated negatively with atrophy scores. When PG I/II was less than 3.4, 5.4 or 6.7, the probability of the open type of gastric atrophy was estimated to be 75%, 50%, or 25%, respectively. Conclusion Our results suggest that serum PG levels measured after H. pylori eradication can be used to estimate the degree of gastric mucosal atrophy and are useful for selecting individuals with a high risk of gastric cancer after H. pylori eradication.

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Association of serum pepsinogen with degree of gastric mucosal atrophy in an asymptomatic population

World Journal of Clinical Cases ◽

10.12998/wjcc.v9.i31.9431 ◽

2021 ◽

Vol 9 (31) ◽

pp. 9431-9439

Author(s):

Hao-Lei Cai ◽

Yu-Ling Tong

Keyword(s):

Serum Pepsinogen ◽

Mucosal Atrophy ◽

Gastric Mucosal Atrophy

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Association of dietary patterns and endoscopic gastric mucosal atrophy in an adult Chinese population

Scientific Reports ◽

10.1038/s41598-019-52951-7 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 1

Author(s):

Song Lin ◽

Tao Gao ◽

Chongxiu Sun ◽

Mengru Jia ◽

Chengxia Liu ◽

...

Keyword(s):

Confidence Interval ◽

Dietary Patterns ◽

Odds Ratio ◽

Adjusted Odds Ratio ◽

Dietary Intakes ◽

Mucosal Atrophy ◽

Gastric Mucosal Atrophy ◽

Increased Risk ◽

Group Frequency ◽

H Pylori

Abstract Atrophy gastritis harbor a high risk for the development of dysplasia and gastric cancer. The study investigated the relationships of specific dietary patterns and endoscopic gastric mucosal atrophy. In this cross-sectional study, we enrolled 574 consecutive outpatients who were diagnosed as chronic gastritis according to endoscopic examination. Dietary intakes of study individuals was assessed using the semi-quantitative food group frequency questionnaire. Logistic regression analyses were used to evaluate the relationship between dietary patterns and endoscopic gastric mucosal atrophy adjusted for potential confounders. A total of 574 participants were included, 286 with endoscopic gastric mucosal atrophy. Three dietary patterns were identified by factor analysis. “Alcohol and fish” (tertile 1 vs. tertile 3: adjusted odds ratio = 1.85, 95% confidence interval: 1.06–3.22) and “coarse cereals” (tertile 1 vs. tertile 3: adjusted odds ratio = 2.05, 95% confidence interval: 1.24–3.39) were associated with an increased risk for endoscopic gastric mucosal atrophy but a “traditional” pattern was not. Dietary pattern was not associated with gastric mucosal atrophy in women or in participants with H. pylori infection. A high adherence to both “Alcohol and Fish” and “Coarse cereals” dietary patterns seem to be associated with higher odds of endoscopic gastric mucosal atrophy in men and in patients without H. pylori infection. Further prospective cohort studies needed to confirm these findings.

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Analysis of negative result in serum anti-H. pylori IgG antibody test in cases with gastric mucosal atrophy

Journal of Clinical Biochemistry and Nutrition ◽

10.3164/jcbn.16-13 ◽

2016 ◽

Vol 59 (2) ◽

pp. 145-148 ◽

Cited By ~ 10

Author(s):

Kyoichi Adachi ◽

Tomoko Mishiro ◽

Shino Tanaka ◽

Yoshikazu Kinoshita

Keyword(s):

Antibody Test ◽

Igg Antibody ◽

Mucosal Atrophy ◽

Gastric Mucosal Atrophy ◽

H Pylori

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Serum Anti-Helicobacter pylori IgG Antibody Titer in H. pylori-negative Cases with a Different Gastric Mucosal Atrophy Status

Internal Medicine ◽

10.2169/internalmedicine.5132-20 ◽

2020 ◽

Vol 59 (22) ◽

pp. 2817-2823

Author(s):

Kyoichi Adachi ◽

Kanako Kishi ◽

Takumi Notsu ◽

Tomoko Mishiro ◽

Kazunari Sota ◽

...

Keyword(s):

Helicobacter Pylori ◽

Antibody Titer ◽

Igg Antibody ◽

Mucosal Atrophy ◽

Gastric Mucosal Atrophy ◽

H Pylori

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Severity of Gastric Mucosal Atrophy Is the Major Determinant of Plasma Ghrelin Level in Hemodialysis Patients

American Journal of Nephrology ◽

10.1159/000449019 ◽

2016 ◽

Vol 44 (3) ◽

pp. 224-233 ◽

Cited By ~ 5

Author(s):

Yukitoshi Sakao ◽

Mitsushige Sugimoto ◽

Hitomi Ichikawa ◽

Shu Sahara ◽

Takayuki Tsuji ◽

...

Keyword(s):

Management Practices ◽

Ghrelin Level ◽

Major Determinant ◽

Rapid Urease Test ◽

Mucosal Atrophy ◽

Plasma Ghrelin Level ◽

Gastric Mucosal Atrophy ◽

Urease Test ◽

Acyl Ghrelin ◽

H Pylori

Background: Ghrelin, an orexigenic hormone, has multiple favorable functions including protein anabolism enhancement, anti-inflammatory actions, and cardiovascular protection. A low plasma ghrelin level is associated with increased mortality in patients treated with hemodialysis (HD). However, it is unclear whether the plasma ghrelin level in HD patients correlates with the severity of gastric mucosal atrophy and Helicobacter pylori status. Methods: Seventy-eight maintenance HD patients and 51 non-dialysis patients with chronic kidney disease were evaluated for severity of gastric mucosal atrophy by gastroduodenoscopy and for H. pylori status using an anti-H. pylori-antibody and rapid urease test. Plasma acyl and des-acyl ghrelin levels were measured and their associations with relevant clinical parameters were investigated. Results: Des-acyl ghrelin level in HD patients was significantly higher than that in patients with kidney function preserved. Although acyl and des-acyl ghrelin levels were similar between current H. pylori positive and negative HD patients, both levels decreased significantly with the progress of endoscopic gastric mucosal atrophy in HD patients. Serum pepsinogen (PG) I level and PG I/II ratio decreased significantly according to the severity of atrophy in HD patients and positively significantly correlated with both ghrelin levels. Multiple regression analysis showed significant positive correlations between acyl ghrelin and PG I levels (β = 0.738, p < 0.001) and significant negative correlations between ghrelin and age, albumin, and creatinine levels. Conclusions: Gastric atrophy is the major determinant of ghrelin level in HD patients. Management practices, such as H. pylori eradication, before advanced atrophy may be required to prevent the decrease of ghrelin levels and improve the prognosis of HD patients.

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Seroprevalence of Helicobacter pylori infection and gastric mucosal atrophy in Bhutan, a country with a high prevalence of gastric cancer

Journal of Medical Microbiology ◽

10.1099/jmm.0.060905-0 ◽

2013 ◽

Vol 62 (10) ◽

pp. 1571-1578 ◽

Cited By ~ 19

Author(s):

Seiji Shiota ◽

Varocha Mahachai ◽

Ratha-korn Vilaichone ◽

Thawee Ratanachu-ek ◽

Lotay Tshering ◽

...

Keyword(s):

Gastric Cancer ◽

Helicobacter Pylori ◽

Negative Group ◽

Mucosal Atrophy ◽

Gastric Mucosal Atrophy ◽

High Prevalence ◽

Group A ◽

H Pylori ◽

Group B ◽

Group D

Gastric cancer is the second leading cause of cancer-related mortality in the world. Recently, serum Helicobacter pylori antibodies and pepsinogen (PG) have been used for gastric cancer screening. The incidence of gastric cancer in Bhutan is reported to be quite high compared with that in neighbouring countries. In this study, 381 subjects from three areas of Bhutan were assessed for gastric mucosal atrophy and serological parameters. Anti-H. pylori IgG, PG I, PG II and cytotoxin-associated gene A (CagA) antibodies were measured using ELISA. Subjects were classified into four groups according to H. pylori and PG seropositivity: Group A (H. pylori-negative/PG-negative), Group B (H. pylori-positive/PG-negative), Group C (H. pylori-positive/PG-positive) and Group D (H. pylori-negative/PG-positive). The prevalence of H. pylori in the 381 subjects was 71.1 % (271/381), with high infection rates found in rural areas. The PG I/II ratio was significantly inversely correlated with the atrophy score in the antrum and the corpus (P<0.001). Multivariate analysis showed that the PG status was significantly associated with the presence of atrophy in the corpus. The prevalence of the PG-positive status was significantly higher among H. pylori-positive subjects than among H. pylori-negative subjects (P<0.001). Based on the ABC method, Group B was the most dominant, followed by Group A, Group C and Group D. The high incidence of gastric cancer in Bhutan can be attributed to the high prevalence of H. pylori infection and gastric mucosal atrophy.

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Pathogenesis of helicobacter pylori infection: Bacterium and host relationship

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh0410340s ◽

2004 ◽

Vol 132 (9-10) ◽

pp. 340-344 ◽

Cited By ~ 3

Author(s):

Aleksandra Sokic-Milutinovic ◽

Vera Todorovic ◽

Tomica Milosavljevic

Keyword(s):

Helicobacter Pylori ◽

Gastric Mucosa ◽

Dietary Habits ◽

Chronic Phase ◽

Mucosal Injury ◽

Blood Type ◽

Gastric Epithelium ◽

Mucosal Atrophy ◽

Gastric Mucosal Atrophy ◽

H Pylori

Helicobacter pylori (H. pylori) colonizes the gastric mucosa of a half of the mankind. Duodenal ulcer is found in 15-25%, t gastric ulcer in 13%, while gastric adenocarcinoma develops in 1% of all infected individuals. Pathogenesis of H. pylori infection is related to the virulence factors of the bacterium, environmental (dietary habits, hygiene, stress) and host factors (age, sex, blood type). Colonization of the gastric mucosa is related to the motility of the bacterium, presence of lipopolysacharide (LPS) and various bacterial enzymes. Gastric mucosal injury is the result of H. pylori LPS, vacuolization cytotoxin (vacA), cytotoxin associated protein (cagA), heat shock proteins and factors responsible for neutrophil chemotaxis and activity. H. pylori colonizes the gastric mucosa and zones of ectopic gastric epithelium. H. pylori infection is transmitted via oral-oral, fecal-oral and iatrogenic way (during endoscopy). Higher prevalence of the infection is associated with lower socioeconomic level, lack of drinking water, and living in a community. Acute H. pylori gastritis is superficial pangastritis progressing into the chronic phase after 7-10 days. Gastric mucosal atrophy and intestinal metaplasia can develop during the course of H. pylori infection. Clearly defined factors that influence the outcome of H. pylori infection include bacterial strain, distribution of gastritis, acid secretion and gastric mucosal atrophy.

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