scholarly journals Serum Anti-Helicobacter pylori IgG Antibody Titer in H. pylori-negative Cases with a Different Gastric Mucosal Atrophy Status

2020 ◽  
Vol 59 (22) ◽  
pp. 2817-2823
Author(s):  
Kyoichi Adachi ◽  
Kanako Kishi ◽  
Takumi Notsu ◽  
Tomoko Mishiro ◽  
Kazunari Sota ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Antibody Titer ◽  
Igg Antibody ◽  
Mucosal Atrophy ◽  
Gastric Mucosal Atrophy ◽  
H Pylori

scholarly journals Analysis of negative result in serum anti-H. pylori IgG antibody test in cases with gastric mucosal atrophy

2016 ◽  
Vol 59 (2) ◽  
pp. 145-148 ◽  
Author(s):  
Kyoichi Adachi ◽  
Tomoko Mishiro ◽  
Shino Tanaka ◽  
Yoshikazu Kinoshita
Keyword(s):  
Antibody Test ◽  
Igg Antibody ◽  
Mucosal Atrophy ◽  
Gastric Mucosal Atrophy ◽  
H Pylori

scholarly journals Estimation of the degree of gastric mucosal atrophy based on serum pepsinogen levels after eradication of Helicobacter pylori

2020 ◽  
Author(s):  
Takahiro Suzuki ◽  
Tomohiro Higuchi ◽  
Takuma Kagami ◽  
Mihoko Yamade ◽  
Shinya Tani ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Serum Levels ◽  
Gastric Atrophy ◽  
Mucosal Inflammation ◽  
Serum Pepsinogen ◽  
Mucosal Atrophy ◽  
Gastric Mucosal Atrophy ◽  
H Pylori

Abstract Background Serum pepsinogen (PG) levels correlate with the degree of gastric mucosal inflammation and atrophy, which correlate with gastric cancer risk, in patients infected with Helicobacter pylori (H. pylori). Serum PG levels change after eradication of H. pylori, but it is not known if there are corresponding changes in the gastric mucosa. We examined whether the degree of gastric atrophy correlated with PG levels measured after eradication of H. pylori. Methods We retrospectively examined the relationship between gastric atrophy and serum levels of PG I, PG II and PG I/II ratios measured after eradication of H. pylori. The degree of gastric mucosal atrophy before H. pylori eradication was scored (0, 1, 2) according to the Kyoto classification of gastritis. Results A total of 430 treated patients were enrolled. Serum levels of PG I (ρ = − 0.362 and P < 0.001), PG II (ρ = − 0.158 and P = 0.001) and PG I/II ratio (ρ = − 0.337 and P < 0.001) all correlated negatively with atrophy scores. When PG I/II was less than 3.4, 5.4 or 6.7, the probability of the open type of gastric atrophy was estimated to be 75%, 50%, or 25%, respectively. Conclusion Our results suggest that serum PG levels measured after H. pylori eradication can be used to estimate the degree of gastric mucosal atrophy and are useful for selecting individuals with a high risk of gastric cancer after H. pylori eradication.

scholarly journals Seroprevalence of Helicobacter pylori infection and gastric mucosal atrophy in Bhutan, a country with a high prevalence of gastric cancer

2013 ◽  
Vol 62 (10) ◽  
pp. 1571-1578 ◽  
Author(s):  
Seiji Shiota ◽  
Varocha Mahachai ◽  
Ratha-korn Vilaichone ◽  
Thawee Ratanachu-ek ◽  
Lotay Tshering ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Negative Group ◽  
Mucosal Atrophy ◽  
Gastric Mucosal Atrophy ◽  
High Prevalence ◽  
Group A ◽  
H Pylori ◽  
Group B ◽  
Group D

Gastric cancer is the second leading cause of cancer-related mortality in the world. Recently, serum Helicobacter pylori antibodies and pepsinogen (PG) have been used for gastric cancer screening. The incidence of gastric cancer in Bhutan is reported to be quite high compared with that in neighbouring countries. In this study, 381 subjects from three areas of Bhutan were assessed for gastric mucosal atrophy and serological parameters. Anti-H. pylori IgG, PG I, PG II and cytotoxin-associated gene A (CagA) antibodies were measured using ELISA. Subjects were classified into four groups according to H. pylori and PG seropositivity: Group A (H. pylori-negative/PG-negative), Group B (H. pylori-positive/PG-negative), Group C (H. pylori-positive/PG-positive) and Group D (H. pylori-negative/PG-positive). The prevalence of H. pylori in the 381 subjects was 71.1 % (271/381), with high infection rates found in rural areas. The PG I/II ratio was significantly inversely correlated with the atrophy score in the antrum and the corpus (P<0.001). Multivariate analysis showed that the PG status was significantly associated with the presence of atrophy in the corpus. The prevalence of the PG-positive status was significantly higher among H. pylori-positive subjects than among H. pylori-negative subjects (P<0.001). Based on the ABC method, Group B was the most dominant, followed by Group A, Group C and Group D. The high incidence of gastric cancer in Bhutan can be attributed to the high prevalence of H. pylori infection and gastric mucosal atrophy.

scholarly journals Pathogenesis of helicobacter pylori infection: Bacterium and host relationship

2004 ◽  
Vol 132 (9-10) ◽  
pp. 340-344 ◽  
Author(s):  
Aleksandra Sokic-Milutinovic ◽  
Vera Todorovic ◽  
Tomica Milosavljevic
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Dietary Habits ◽  
Chronic Phase ◽  
Mucosal Injury ◽  
Blood Type ◽  
Gastric Epithelium ◽  
Mucosal Atrophy ◽  
Gastric Mucosal Atrophy ◽  
H Pylori

Helicobacter pylori (H. pylori) colonizes the gastric mucosa of a half of the mankind. Duodenal ulcer is found in 15-25%, t gastric ulcer in 13%, while gastric adenocarcinoma develops in 1% of all infected individuals. Pathogenesis of H. pylori infection is related to the virulence factors of the bacterium, environmental (dietary habits, hygiene, stress) and host factors (age, sex, blood type). Colonization of the gastric mucosa is related to the motility of the bacterium, presence of lipopolysacharide (LPS) and various bacterial enzymes. Gastric mucosal injury is the result of H. pylori LPS, vacuolization cytotoxin (vacA), cytotoxin associated protein (cagA), heat shock proteins and factors responsible for neutrophil chemotaxis and activity. H. pylori colonizes the gastric mucosa and zones of ectopic gastric epithelium. H. pylori infection is transmitted via oral-oral, fecal-oral and iatrogenic way (during endoscopy). Higher prevalence of the infection is associated with lower socioeconomic level, lack of drinking water, and living in a community. Acute H. pylori gastritis is superficial pangastritis progressing into the chronic phase after 7-10 days. Gastric mucosal atrophy and intestinal metaplasia can develop during the course of H. pylori infection. Clearly defined factors that influence the outcome of H. pylori infection include bacterial strain, distribution of gastritis, acid secretion and gastric mucosal atrophy.

scholarly journals Serodiagnosis and Bacterial Genome of Helicobacter pylori Infection

Toxins ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 467
Author(s):  
Aina Ichihara ◽  
Hinako Ojima ◽  
Kazuyoshi Gotoh ◽  
Osamu Matsushita ◽  
Susumu Take ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Antibody Titer ◽  
Bacterial Genome ◽  
Serum Antibody ◽  
Gene Mutations ◽  
Bacterial Genomes ◽  
Western Blots ◽  
A Genome ◽  
Vaca Gene ◽  
H Pylori

The infection caused by Helicobacter pylori is associated with several diseases, including gastric cancer. Several methods for the diagnosis of H. pylori infection exist, including endoscopy, the urea breath test, and the fecal antigen test, which is the serum antibody titer test that is often used since it is a simple and highly sensitive test. In this context, this study aims to find the association between different antibody reactivities and the organization of bacterial genomes. Next-generation sequences were performed to determine the genome sequences of four strains of antigens with different reactivity. The search was performed on the common genes, with the homology analysis conducted using a genome ring and dot plot analysis. The two antigens of the highly reactive strains showed a high gene homology, and Western blots for CagA and VacA also showed high expression levels of proteins. In the poorly responsive antigen strains, it was found that the inversion occurred around the vacA gene in the genome. The structure of bacterial genomes might contribute to the poor reactivity exhibited by the antibodies of patients. In the future, an accurate serodiagnosis could be performed by using a strain with few gene mutations of the antigen used for the antibody titer test of H. pylori.

scholarly journals Seroprevalence of Helicobacter pylori in patients with colon adenomas in a brazilian university hospital

2009 ◽  
Vol 46 (2) ◽  
pp. 97-101 ◽  
Author(s):  
Abadia Gilda Buso ◽  
Haroldo Luis Oliva Gomes Rocha ◽  
Débora Miranda Diogo ◽  
Priscila Miranda Diogo ◽  
Augusto Diogo-Filho
Keyword(s):  
Helicobacter Pylori ◽  
Solid Phase ◽  
Positive Association ◽  
University Hospital ◽  
Igg Antibody ◽  
Chi Square ◽  
Colon Adenomas ◽  
Colonic Adenomas ◽  
Significant Difference ◽  
H Pylori

CONTEXT: The association between Helicobacter pylori infection and colon neoplasia has been the subject of recent investigations which have produced controversial results. OBJECTIVE: To evaluate the prevalence of H. pylori infection in patients with colonic adenomas and also in patients whose colonoscopy exams were normal. METHODS: After colonoscopy, the individuals were distributed into two groups: patients with colon adenomas (cases) and patients whose colons were normal (controls). The groups were similar regarding age and gender. The individuals of both groups were subjected to a dosage of IgG antibody against H. pylori. The dosage was applied according to the solid phase, chemiluminescent immunometric assay. The chi-square test was used to analyze the data. RESULTS: There were 30 men and 64 women in each group (94 cases and 94 controls). The mean age of the cases was 59.79 ± 12.25 years and that of the controls was 58.98 ± 11.55 years. The H. pylori serology was positive for 66 (70.21%) of the cases and for 51 (54.25%) of the controls. There was a significant difference (P = 0.024). The odds ratio was 1.98 (CI 95%, 0.82-3.15). The prevalence of H. pylori in cases and controls according to gender, histological type and location of the colon lesions showed a significant difference only among women (P = 0.03), among patients with tubular adenomas (P = 0.03), and in those with distal adenomas (P = 0.038). CONCLUSION: There is a positive association between H. pylori infection and colonic adenomas. This association is more evident in women, especially for tubular adenomas and distal colonic location.

scholarly journals Correlates of infection with Helicobacter pylori positive and negative cytotoxin-associated gene A phenotypes among Arab and Jewish residents of Jerusalem

2019 ◽  
Vol 147 ◽  
Author(s):  
K. Muhsen ◽  
R. Sinnereich ◽  
G. Beer-Davidson ◽  
H. Nassar ◽  
W. Abu Ahmed ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Former Soviet Union ◽  
Enzyme Linked Immunosorbent Assay ◽  
Igg Antibodies ◽  
Multinomial Regression ◽  
Igg Antibody ◽  
Sibship Size ◽  
Cross Sectional ◽  
Cytotoxin Associated Gene A ◽  
H Pylori

Abstract We examined the prevalence and correlates of Helicobacter pylori (H. pylori) infection according to cytotoxin-associated gene A (CagA) phenotype, a main virulence antigen, among the ethnically diverse population groups of Jerusalem. A cross-sectional study was undertaken in Arab (N = 959) and Jewish (N = 692) adults, randomly selected from Israel's national population registry in age-sex and population strata. Sera were tested for H. pylori immunoglobulin G (IgG) antibodies. Positive samples were tested for virulence IgG antibodies to recombinant CagA protein, by enzyme-linked immunosorbent assay. Multinomial regression models were fitted to examine associations of sociodemographic factors with H. pylori phenotypes. H. pylori IgG antibody sero-prevalence was 83.3% (95% confidence interval (CI) 80.0%–85.5%) and 61.4% (95% CI 57.7%–65.0%) among Arabs and Jews, respectively. Among H. pylori positives, the respective CagA IgG antibody sero-positivity was 42.3% (95% CI 38.9%–45.8%) and 32.5% (95% CI 28.2%–37.1%). Among Jews, being born in the Former Soviet Union, the Middle East and North Africa, vs. Israel and the Americas, was positively associated with CagA sero-positivity. In both populations, sibship size was positively associated with both CagA positive and negative phenotypes; and education was inversely associated. In conclusion, CagA positive and negative infection had similar correlates, suggesting shared sources of these two H. pylori phenotypes.

scholarly journals Association of dietary patterns and endoscopic gastric mucosal atrophy in an adult Chinese population

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Song Lin ◽  
Tao Gao ◽  
Chongxiu Sun ◽  
Mengru Jia ◽  
Chengxia Liu ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Dietary Patterns ◽  
Odds Ratio ◽  
Adjusted Odds Ratio ◽  
Dietary Intakes ◽  
Mucosal Atrophy ◽  
Gastric Mucosal Atrophy ◽  
Increased Risk ◽  
Group Frequency ◽  
H Pylori

Abstract Atrophy gastritis harbor a high risk for the development of dysplasia and gastric cancer. The study investigated the relationships of specific dietary patterns and endoscopic gastric mucosal atrophy. In this cross-sectional study, we enrolled 574 consecutive outpatients who were diagnosed as chronic gastritis according to endoscopic examination. Dietary intakes of study individuals was assessed using the semi-quantitative food group frequency questionnaire. Logistic regression analyses were used to evaluate the relationship between dietary patterns and endoscopic gastric mucosal atrophy adjusted for potential confounders. A total of 574 participants were included, 286 with endoscopic gastric mucosal atrophy. Three dietary patterns were identified by factor analysis. “Alcohol and fish” (tertile 1 vs. tertile 3: adjusted odds ratio = 1.85, 95% confidence interval: 1.06–3.22) and “coarse cereals” (tertile 1 vs. tertile 3: adjusted odds ratio = 2.05, 95% confidence interval: 1.24–3.39) were associated with an increased risk for endoscopic gastric mucosal atrophy but a “traditional” pattern was not. Dietary pattern was not associated with gastric mucosal atrophy in women or in participants with H. pylori infection. A high adherence to both “Alcohol and Fish” and “Coarse cereals” dietary patterns seem to be associated with higher odds of endoscopic gastric mucosal atrophy in men and in patients without H. pylori infection. Further prospective cohort studies needed to confirm these findings.

Tu1292 - Plasma Ghrelin is a Useful Marker of Gastric Mucosal Atrophy after Helicobacter Pylori Eradication: A Prospective Clinical Study

2018 ◽  
Vol 154 (6) ◽  
pp. S-925-S-926
Author(s):  
Hideki Mori ◽  
Hidekazu Suzuki ◽  
Juntaro Matsuzaki ◽  
Tatsuhiro Masaoka ◽  
Koji Igarashi ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Clinical Study ◽  
Prospective Clinical Study ◽  
Helicobacter Pylori Eradication ◽  
Mucosal Atrophy ◽  
Gastric Mucosal Atrophy
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