P433 The uNK cell in human decidua of normal pregnancy and spontaneous abortion in the first trimester pregnancy and its angiogenic function regulated by progesterone and IL-15

OBJECTIVE: There are cases where ultrasonographic evaluation is inadequate in determining first-trimester healthy pregnancy. In these cases, both the patient and the clinician are involved in a worrying expectation. The single serum progesterone measurement was tried to predict pregnancy prognosis in short time period. This study evaluated the predictive value of a single serum progesterone measurement in first-trimester pregnancy loss.STUDY DESIGN: A prospective case-control study was conducted between July 2013 and July 2014 in Tertiary Hospital. The study compared 106 patients with threatened abortion (vaginal bleeding or spotting) before 13 weeks of gestation with 110 healthy control pregnancies. Samples of serum progesterone were obtained on the day each patient was admitted to the hospital. A Beckman-Coulter macro-Enzyme-linked immunoassay (ELISA) system was used to measure serum levels of progesterone (Beckman-Coulter, Ireland).RESULTS: Progesterone levels were measured when the patients first visited the hospital and they were followed until the end of the first trimester. Progesterone levels differed significantly (p=0.013) between the two groups. The spontaneous abortion rate was significantly (p=0.044) higher in the case group. Progesterone levels differed significantly (p=0.001) between ongoing pregnancy and spontaneous abortion groups. Using a cut-off level of 10.7 ng/mL, the sensitivity, specificity, and positive and negative predictive values were 92.1%, 44%, 92.6%, and 42.3%, respectively, for viable pregnancies.CONCLUSION: A single measurement of progesterone levels in serum can predict the prognosis of a viable first-trimester pregnancy, while it is less effective for identifying non-viable pregnancies.

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Is There an Association Between Early Pregnancy Losses and Low 25-Hydroxy Vitamin D Levels?

POJ Gynaecology & Obstetrics Research ◽

10.32648/2578-8787/1/1/004 ◽

2017 ◽

Vol 1 (1) ◽

pp. 1-5

Author(s):

Lebriz Hale Aktun ◽

Yeliz Aykanat ◽

Oktay Olmuscelik

Keyword(s):

Vitamin D ◽

Early Pregnancy ◽

Pregnancy Loss ◽

First Trimester ◽

Normal Pregnancy ◽

First Trimester Pregnancy ◽

Pregnancy History ◽

Trimester Pregnancy ◽

25 Hydroxy Vitamin D

Objective: Since the etiology of pregnancy losses during first trimester has not still been clear, we aim to analyze the relationship between vitamin D deficiency and early pregnancy losses. Patients and Methods: The study was conducted on 200 women. Plasma was collected from 100 nulliparous women with singleton at 7-10 weeks of gestation (50 with viable gestation and 50 with pregnancy loss) and 100 non-gravid reproductive age women (50 with a successful pregnancy history and 50 with one or more spontaneous first trimester pregnancy loss history). Serum 25 (OH) D and calcium levels were compared between groups. Results: The serum 25(OH) D levels for the groups turned out to be 47.64 ± 3.2 (95% CI: 44.4-50.8 ng/ml) for normal pregnancy group, 27.3 ± 1.2 (95% CI: 26.1-28.5 ng/ml) for the group of early pregnancy loss, 38.5 ± 5.1 (95% CI: 33.4-43.6 ng/ml) for the non gravid women with healthy pregnancy history and 11.6 ± 4.2 (95% CI: 7.9 - 15.6 ng/ml) for the non-gravid women with history of 1 or more first trimester pregnancy loss. There was a strong correlation between low 25(OH) D levels and early pregnancy loss (odds ratio (OR): 1.70, 95% CI: 1.2-2.3, p <0.001). The calcium levels were significantly lower in pregnancy loss group than normal pregnancy and non-gravid groups (p=0.005, p=0.033 respectively). Conclusions: Although our study is emphasized on role of vitamin D in early pregnancy it is not possible to recommend screening and supplementation of vitamin D in early pregnancy, as prognosis of pregnancies receiving supplementation and the incidence of pregnancy related complications in follow-up are not known. Well designed studies with long term follow up results needed. Keywords: 25 hydroxy vitamin D, Pregnancy loss, 25 (OH) D vitamin

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