scholarly journals Protective effects of T-588, a novel cognition enhancer, on β-amyloid protein, serum deprivation and glutamate induced neurotoxicity in primary rat hippocampal neurons and cerebellar granule cells

1997 ◽  
Vol 73 ◽  
pp. 280
Author(s):  
Noboru Iwakami ◽  
Hidetoshi Yamaguchi ◽  
Satoshi Ono ◽  
Hirokazu Narita
Keyword(s):  
Hippocampal Neurons ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Serum Deprivation ◽  
Protective Effects ◽  
Amyloid Protein ◽  
Cerebellar Granule ◽  
Β Amyloid ◽  
Protein Serum

17β-Estradiol protects cerebellar granule cells against β-amyloid-induced toxicity via the apoptotic mitochondrial pathway

2014 ◽  
Vol 561 ◽  
pp. 134-139 ◽  
Author(s):  
Maddalena Napolitano ◽  
Loredana Costa ◽  
Roberto Piacentini ◽  
Claudio Grassi ◽  
Antonio Lanzone ◽  
...  
Keyword(s):  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Mitochondrial Pathway ◽  
Cerebellar Granule ◽  
17Β Estradiol ◽  
Β Amyloid

Fragment 31–35 of β-amyloid peptide induces neurodegeneration in rat cerebellar granule cells via bax gene expression and caspase-3 activation

2006 ◽  
Vol 49 (5) ◽  
pp. 525-532 ◽  
Author(s):  
Francesco Misiti ◽  
M. Elisabetta Clementi ◽  
Giuseppe Tringali ◽  
Mauro Vairano ◽  
Federica Orsini ◽  
...  
Keyword(s):  
Gene Expression ◽  
Caspase 3 ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Amyloid Peptide ◽  
Cerebellar Granule ◽  
Β Amyloid ◽  
Β Amyloid Peptide ◽  
Bax Gene

scholarly journals Very-KIND, a KIND domain–containing RasGEF, controls dendrite growth by linking Ras small GTPases and MAP2

2007 ◽  
Vol 179 (3) ◽  
pp. 539-552 ◽  
Author(s):  
Jinhong Huang ◽  
Asako Furuya ◽  
Teiichi Furuichi
Keyword(s):  
Hippocampal Neurons ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Small Gtpases ◽  
Dendrite Growth ◽  
Nucleotide Exchange ◽  
Cerebellar Granule ◽  
Nucleotide Exchange Factor ◽  
Dendritic Shaft ◽  
Developing Mouse Brain

The regulation of cytoskeletal components in the dendritic shaft core is critical for dendrite elongation and branching. Here, we report that a brain-specific Ras guanine nucleotide exchange factor (RasGEF) carrying two kinase non-catalytic C-lobe domains (KINDs), very-KIND (v-KIND), regulates microtubule-associated protein 2 (MAP2). v-KIND is expressed in developing mouse brain, predominantly in the cerebellar granule cells. v-KIND not only activates Ras small GTPases via the C-terminal RasGEF domain, but also specifically binds to MAP2 via the second KIND domain (KIND2), leading to threonine phosphorylation of MAP2. v-KIND overexpression suppresses dendritic extension and branching of hippocampal neurons and cerebellar granule cells, whereas knockdown of endogenous v-KIND expression promotes dendrite growth. These findings suggest that v-KIND mediates a signaling pathway that links Ras and MAP2 to control dendrite growth.

C-Phycocyanin protects cerebellar granule cells from low potassium/serum deprivation-induced apoptosis

2001 ◽  
Vol 364 (2) ◽  
pp. 96-104 ◽  
Author(s):  
Víctor Rimbau ◽  
Antoni Camins ◽  
David Pubill ◽  
Francesc Sureda ◽  
Cheyla Romay ◽  
...  
Keyword(s):  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Serum Deprivation ◽  
Cerebellar Granule ◽  
Low Potassium ◽  
Induced Apoptosis

Protective effects of nicotine on ethanol-induced toxicity in cultured cerebellar granule cells

2003 ◽  
Vol 5 (5) ◽  
pp. 315-321 ◽  
Author(s):  
Yousef Tizabi ◽  
Mashael Al-Namaeh ◽  
Kebreten F. Manaye ◽  
Robert E. Taylor
Keyword(s):  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Protective Effects ◽  
Cerebellar Granule
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