scholarly journals Regulation of the cellular stress response by reactive electrophiles. The role of covalent binding and cellular thiols in transcriptional activation of the 70-kilodalton heat shock protein gene by nephrotoxic cysteine conjugates.

1992 ◽  
Vol 267 (34) ◽  
pp. 24322-24327
Author(s):  
Q Chen ◽  
K Yu ◽  
J.L. Stevens
Keyword(s):  
Stress Response ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Transcriptional Activation ◽  
Protein Gene ◽  
Cellular Stress ◽  
Covalent Binding ◽  
Cellular Stress Response ◽  
Heat Shock Protein Gene

scholarly journals Flavonoids: Potential Candidates for the Treatment of Neurodegenerative Disorders

Biomedicines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 99
Author(s):  
Shweta Devi ◽  
Vijay Kumar ◽  
Sandeep Kumar Singh ◽  
Ashish Kant Dubey ◽  
Jong-Joo Kim
Keyword(s):  
Stress Response ◽  
Stress Responses ◽  
Neurodegenerative Disorders ◽  
Cell Damage ◽  
Cellular Stress ◽  
Clinical Manifestations ◽  
Cellular Stress Response ◽  
Dramatic Rise ◽  
Cellular Stress Responses

Neurodegenerative disorders, such as Parkinson’s disease (PD), Alzheimer’s disease (AD), Amyotrophic lateral sclerosis (ALS), and Huntington’s disease (HD), are the most concerning disorders due to the lack of effective therapy and dramatic rise in affected cases. Although these disorders have diverse clinical manifestations, they all share a common cellular stress response. These cellular stress responses including neuroinflammation, oxidative stress, proteotoxicity, and endoplasmic reticulum (ER)-stress, which combats with stress conditions. Environmental stress/toxicity weakened the cellular stress response which results in cell damage. Small molecules, such as flavonoids, could reduce cellular stress and have gained much attention in recent years. Evidence has shown the potential use of flavonoids in several ways, such as antioxidants, anti-inflammatory, and anti-apoptotic, yet their mechanism is still elusive. This review provides an insight into the potential role of flavonoids against cellular stress response that prevent the pathogenesis of neurodegenerative disorders.

scholarly journals Mitochondrien unter Stress: Die Rolle der Präsequenzprotease MPP

BIOspektrum ◽  
2021 ◽  
Vol 27 (4) ◽  
pp. 390-393
Author(s):  
F.-Nora Vögtle
Keyword(s):  
Stress Response ◽  
Cellular Stress ◽  
Critical Role ◽  
Mitochondrial Protein ◽  
Nuclear Genome ◽  
Cellular Stress Response ◽  
Mitochondrial Proteins ◽  
Protein Biogenesis ◽  
Cellular Integrity

AbstractThe majority of mitochondrial proteins are encoded in the nuclear genome, so that the nearly entire proteome is assembled by post-translational preprotein import from the cytosol. Proteomic imbalances are sensed and induce cellular stress response pathways to restore proteostasis. Here, the mitochondrial presequence protease MPP serves as example to illustrate the critical role of mitochondrial protein biogenesis and proteostasis on cellular integrity.

Sequence Characterization of Heat Shock Protein Gene ofCyclospora cayetanensisIsolates from Nepal, Mexico, and Peru

2013 ◽  
Vol 99 (2) ◽  
pp. 379-382 ◽  
Author(s):  
Irshad M. Sulaiman ◽  
Patricia Torres ◽  
Steven Simpson ◽  
Khalil Kerdahi ◽  
Ynes Ortega
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Protein Gene ◽  
Heat Shock Protein Gene ◽  
Sequence Characterization

Crohn??s disease and polymorphism of heat shock protein gene HSP70-2 in the Tunisian population

2007 ◽  
Vol 19 (3) ◽  
pp. 225-228 ◽  
Author(s):  
Lilia Zouiten-Mekki ◽  
Sami Karoui ◽  
Maher Kharrat ◽  
Monia Fekih ◽  
Samira Matri ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Protein Gene ◽  
Tunisian Population ◽  
Heat Shock Protein Gene
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