0517 Pattern electroretinogram: importance for visual acuity recovery assessment after optic neuritis in multiple sclerosis patients

Objective: The objective of this research was to study the effect of optic neuritis (ON) on axonal damage in multiple sclerosis (MS) patients. Specifically, we compared changes over 2 years in the retinal nerve fibre layer (RNFL) between affected and contralateral eyes in MS patients with a prior history of ON. Methods: Thirty-four patients with one unilateral definitive episode of ON were included and underwent a complete ophthalmic examination, optical coherence tomography (OCT), scanning laser polarimetry, visual evoked potentials (VEP) and pattern electroretinogram (pERG). All patients were re-evaluated at 12 and 24 months. Parameters were compared between ON-affected and contralateral eyes in an initial exploration and over the course of the follow-up. Correlations between parameter changes were analysed. Results: RNFL thickness and functional parameters showed more affection in ON eyes ( p ≤ 0.05), but changes in measurements during the study were similar between both groups of eyes. Conclusions: Progressive axonal loss can be detected in the optic nerve, but ON is not a risk factor for increased chronic damage in MS patients without ophthalmic relapses. Loss of the RNFL is caused by progressive degeneration associated with the disease.

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Agreement analysis comparing iPad LCVA and Sloan testing in multiple sclerosis patients

Multiple Sclerosis Journal ◽

10.1177/1352458517713667 ◽

2017 ◽

Vol 24 (8) ◽

pp. 1126-1130 ◽

Cited By ~ 4

Author(s):

Neda Sattarnezhad ◽

Samantha Farrow ◽

Dorlan Kimbrough ◽

Bonnie Glanz ◽

Brian Healy ◽

...

Keyword(s):

Multiple Sclerosis ◽

Visual Acuity ◽

T Test ◽

Computerized Testing ◽

Low Contrast ◽

Significant Difference ◽

Increased Sensitivity ◽

The Right ◽

Multiple Sclerosis Patients ◽

Paired T Test

Background: Visual symptoms are common in multiple sclerosis (MS). Low-contrast visual acuity (LCVA) testing using Sloan charts has demonstrated increased sensitivity for visual deficits compared to high-contrast acuity testing. Computerized testing of visual acuity may facilitate use in the clinic setting. Objectives: To evaluate the agreement between an iPad-based and Sloan testing of LCVA in a cohort of MS patients. Methods: A total of 38 patients with relapsing-remitting MS were enrolled after providing informed written consent at Partners MS Center, Brigham and Women’s hospital. Monocular LCVA was measured using retroilluminated Sloan chart and iPad-based LogMAR chart. Number of correct letters and agreement between two measurements were assessed for each eye using Bland–Altman analysis and paired t-test. Results: For both eyes, there was no significant difference in number correct between the two measurements using a paired t-test, and there was high correlation between two measurements (oculus dextrus (OD) r = 0.89, p < 0.001; oculus sinister (OS) r = 0.78, p < 0.001). The limits of agreement were −7.9 to +8.5 letters for the right eye and −10.9 to +11.2 letters for the left eye. Conclusion: An iPad-based LCVA test shows good agreement with Sloan testing in MS patients.

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Psychiatric disorders in multiple sclerosis patients

Arquivos de Neuro-Psiquiatria ◽

10.1590/s0004-282x2009000400017 ◽

2009 ◽

Vol 67 (3a) ◽

pp. 664-667 ◽

Cited By ~ 10

Author(s):

Mirella Martins Fazzito ◽

Sérgio Semeraro Jordy ◽

Charles Peter Tilbery

Keyword(s):

Multiple Sclerosis ◽

Psychiatric Disorder ◽

Optic Neuritis ◽

Psychiatric Disorders ◽

Clinical Presentation ◽

Demyelinating Disease ◽

Common Symptom ◽

Multiple Sclerosis Patients ◽

Variable Clinical Presentation

Multiple sclerosis (MS) is a demyelinating disease showing variable clinical presentation. Optic neuritis is the most common symptom, followed by motor and sensitive manifestations. It is known that this disease may be related to several psychiatric disorders, especially depression. In this study we will discribe 5 cases of MS patients harboring psychiatric disorder related or unchained by the disease itself.

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Treatment of corticosteroid refractory optic neuritis in multiple sclerosis patients with intravenous immunoglobulin

European Journal of Neurology ◽

10.1111/j.1468-1331.2008.02258.x ◽

2008 ◽

Vol 15 (11) ◽

pp. 1163-1167 ◽

Cited By ~ 49

Author(s):

A. Tselis ◽

J. Perumal ◽

C. Caon ◽

S. Hreha ◽

W. Ching ◽

...

Keyword(s):

Multiple Sclerosis ◽

Optic Neuritis ◽

Intravenous Immunoglobulin ◽

Multiple Sclerosis Patients

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Analysis of macular and nerve fibre layer thickness in multiple sclerosis patients according to severity level and optic neuritis episodes

Neurología (English Edition) ◽

10.1016/j.nrleng.2014.09.001 ◽

2016 ◽

Vol 31 (6) ◽

pp. 379-388

Author(s):

A. Soler García ◽

F. Padilla Parrado ◽

L.C. Figueroa-Ortiz ◽

A. González Gómez ◽

A. García-Ben ◽

...

Keyword(s):

Multiple Sclerosis ◽

Optic Neuritis ◽

Layer Thickness ◽

Nerve Fibre ◽

Severity Level ◽

Fibre Layer ◽

Nerve Fibre Layer ◽

Multiple Sclerosis Patients

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Mitochondrial haplogroups in Basque multiple sclerosis patients

Multiple Sclerosis Journal ◽

10.1191/1352458504ms1069oa ◽

2004 ◽

Vol 10 (5) ◽

pp. 532-535 ◽

Cited By ~ 20

Author(s):

D Otaegui ◽

A Sáenz ◽

M Martínez-Zabaleta ◽

P Villoslada ◽

I Fernández-Manchola ◽

...

Keyword(s):

Multiple Sclerosis ◽

Mitochondrial Dna ◽

Risk Factor ◽

Environmental Factors ◽

Optic Neuritis ◽

Basque Country ◽

Mitochondrial Haplogroups ◽

Genetic Characteristics ◽

Mitochondrial Haplogroup ◽

Multiple Sclerosis Patients

Previous studies have suggested that mitochondrial metabolism and/or mitochondrial DNA (mtDNA) could be, in conjunction with other genetic or environmental factors, a risk factor for the development of multiple sclerosis (MS). One of these studies establishes that mitochondrial haplogroup JT is a risk factor for developing the disease, in particular the visual manifestations [optic neuritis (ON)]. Nevertheless, as distribution of these haplogroups varies between populations, the observed association may be due to a slanted sample with no physiopathological value. This hypothesis was checked with MS patients, originals from Basque country (this population has peculiar genetic characteristics) and from other Spanish regions. We concluded that such an association does not exist. By contrast, a decrease could be seen in the frequency of the JT haplogroup in the ON group and in the MS-Basque group. That trend could be a protective effect, which needs to be verified in further investigations.

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Reduced visual evoked responses in multiple sclerosis patients with optic neuritis: Comparison of functional magnetic resonance imaging and visual evoked potentials

Multiple Sclerosis Journal ◽

10.1177/135245859900500304 ◽

1999 ◽

Vol 5 (3) ◽

pp. 161-164 ◽

Cited By ~ 24

Author(s):

P J Gareau ◽

J S Gati ◽

R S Menon ◽

D Lee ◽

G Rice ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Multiple Sclerosis ◽

Magnetic Resonance ◽

Functional Magnetic Resonance Imaging ◽

Optic Neuritis ◽

Functional Magnetic Resonance ◽

Resonance Imaging ◽

Multiple Sclerosis Patients ◽

Stimulation Of ◽

Visual Evoked

The limited application of functional magnetic resonance imaging (fMRI) for investigations of multiple sclerosis (MS) patients has already shown that deficits of the motor, cognitive and visual systems may be identified by differences in the patterns of activation in response to a suitable stimulus. In MS patients with unilateral optic neuritis, the area of activation in the primary visual cortex, measured by fMRI techniques, is dramatically reduced in response to stimulation of the affected eye. The latency of the major positive component of the visual evoked potential (VEP) recorded upon stimulation of the affected eye is significantly increased in these patients, as compared to the unaffected eye and normal volunteers. We have found a correlation between the neural response measured using fMRI and the latency of the VEP. fMRI signal responses have the potential to provide more detailed topographic information relating to functional deficits in MS.

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Correlation of optic neuritis and retinal nerve fibre thickness using optical coherence tomography in a cohort of multiple sclerosis patients

African Vision and Eye Health ◽

10.4102/aveh.v75i1.325 ◽

2016 ◽

Vol 75 (1) ◽

Author(s):

Izanne Roos ◽

Rajeshree Budhoo ◽

Linda Visser ◽

Ahmed I. Bhigjee

Keyword(s):

Multiple Sclerosis ◽

Optical Coherence Tomography ◽

Optic Neuritis ◽

Nerve Fibre ◽

Optical Coherence ◽

Macular Volume ◽

Rnfl Thickness ◽

Significant Difference ◽

History Of ◽

Multiple Sclerosis Patients

Background: Optical coherence tomography (OCT) is a fast, non-invasive imaging technology that produces 3D, high-resolution images of the retina. Direct visualisation of the retina allows a unique opportunity to study the effects of multiple sclerosis (MS)-associated neurodegeneration on retinal ganglion cells as well as effects of retrobulbar demyelination on axonal and retinal architecture through measurement of retinal nerve fibre layer (RNFL) thickness and total macular volume (TMV). These findings are clinically important as axonal loss is irreversible and correlates with disability.Aim: To determine the role and usefulness of OCT in a local cohort of MS patients.Setting: Neurology Clinic, Inkosi Albert Luthuli Central Hospital, KwaZulu-Natal, South Africa.Methods: Nineteen patients with MS currently being treated with interferon β-1b underwent OCT examination of both eyes. RNFL thickness and macular volume were measured and correlated with clinical disease characteristics, history of optic neuritis and level of disability.Results: Mean RNFL thickness was 77.3 μm with no significant difference in mean RNFL in eyes with a history of optic neuritis (ON) and those without (p = 0.4). Eyes with a history of ON did, however, have significantly thinner RNFL compared with the contralateral eye (p = 0.04). Despite a strong correlation between TMV and RNFL (p = 0.001), a subset of patients with normal RNFL had TMV that was less than 1% of what was expected. There was no correlation between RNFL and disability scores.Conclusion: OCT enables a direct axonal ‘optical biopsy’, for monitoring disease progression and treatment response in MS. RNFL thinning occurs independently of a history of optic neuritis and may represent a chronic optic neuropathy in patients with MS.Keywords: Multiple sclerosis; optical coherence tomography

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