Re: Urologist Practice Styles in the Initial Evaluation of Elderly Men With Benign Prostatic Hyperplasia

2011 ◽  
Vol 186 (4) ◽  
pp. 1379-1380
Author(s):  
Tomas L. Griebling
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Prostatic Hyperplasia ◽  
Initial Evaluation ◽  
Elderly Men

scholarly journals Urologist Practice Styles in the Initial Evaluation of Elderly Men With Benign Prostatic Hyperplasia

Urology ◽  
2011 ◽  
Vol 77 (3) ◽  
pp. 535-540 ◽  
Author(s):  
Seth A. Strope ◽  
Sean P. Elliott ◽  
Alex Smith ◽  
John T. Wei ◽  
Timothy J. Wilt ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Prostatic Hyperplasia ◽  
Initial Evaluation ◽  
Elderly Men

Diseases of the prostate

2004 ◽  
Vol 14 (2) ◽  
pp. 119-128
Author(s):  
A Cannon ◽  
P Abrams
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Prostate Gland ◽  
Prostatic Hyperplasia ◽  
Histological Diagnosis ◽  
British Association ◽  
International Continence Society ◽  
Elderly Men ◽  
International Consultation ◽  
Stromal Tissue

Benign enlargement of the prostate gland does not always cause symptoms or obstruction to the flow of urine. Old terminology, for example, ‘prostatism’ can therefore be misleading, and the British Association of Urological Surgeons (BAUS), the International consultation on BPH and the International Continence Society accept the definitions given below:Benign prostatic hyperplasia (BPH) is a histological diagnosis. The first pathological signs appear under the age of 40 years, followed by a rapid increase in prevalence with age; 80% of 80-year-olds have evidence of BPH. The onset of BPH is dependent on the presence of functioning testes and increasing age. It is characterized by a combination of atrophy and proliferation in both glandular and stromal tissue. Although BPH is detectable in most elderly men, it does not always cause enlargement of the prostate, symptoms, or obstruction to the flow of urine.

scholarly journals In Vivo Effects of Polymerized Anthocyanin from Grape Skin on Benign Prostatic Hyperplasia

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2444 ◽  
Author(s):  
Young-Jin Choi ◽  
Meiqi Fan ◽  
Yujiao Tang ◽  
Hyun Pil Yang ◽  
Ji-Young Hwang ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Cyclin D1 ◽  
Specific Antigen ◽  
Prostatic Hyperplasia ◽  
Nuclear Antigen ◽  
Elderly Men ◽  
Grape Skin ◽  
Common Chronic Disease ◽  
Metabolic Imbalance

Benign prostatic hyperplasia (BPH) is a common chronic disease of the urinary system among elderly men. Especially, the metabolic imbalance of androgen in elderly men is one of the leading causes of BPH. Dihydrotestosterone (DHT) and converted testosterone by 5-α reductase type 2 (5AR2), binding with androgen receptor (AR), affect prostate proliferation and growth. In BPH, levels of androgen signaling-related protein expression are shown highly. Androgen signaling induces the overexpression of prostate-specific antigen (PSA) and cell proliferation factor such as proliferating cell nuclear antigen (PCNA) and cyclin D1. Grape skin anthocyanins are well known for their antioxidative, anti-cancer, anti-diabetes, anti-inflammatory, antimicrobial, and anti-aging activities. Polymerized anthocyanin (PA) downregulated the expression of androgen signaling-related proteins such as 5AR2, AR, and PSA in LNCaP cell lines. Furthermore, we investigated the effects on PA in testosterone propionate-induced BPH rat experiments. The oral administration of PA decreased the prostate weight in rats with TP-induced BPH. PA decreased the AR, 5AR2, SRC1, PSA, PCNA, and cyclin D1 expression in prostate tissues and the serum DHT levels, ameliorated the BPH-mediated increase of Bcl-2 expression, and increased the Bax expression. These results suggest that PA may be a potential natural therapeutic agent for BPH treatment.

SNPs of Metabolic Syndrome are Associated with Benign Prostatic Hyperplasia Development and Progression in Chinese Population

2020 ◽  
Vol 15 ◽  
Author(s):  
Ding Xu ◽  
Xiaoling Lin ◽  
Xiaoqiang Qian ◽  
Jun Qi
Keyword(s):  
Metabolic Syndrome ◽  
Benign Prostatic Hyperplasia ◽  
Chinese Population ◽  
Systematic Investigation ◽  
Prostatic Hyperplasia ◽  
Common Disease ◽  
Clinical Parameters ◽  
Susceptibility Loci ◽  
Genetic Determinants ◽  
Elderly Men

Objective: Benign prostatic hyperplasia (BPH) is a common disease prevalent in elderly men but the genetic determinants of BPH is still remain unclear. Since metabolic syndrome, especially the diabetes, maybe influences the progression of benign prostatic hyperplasia, we investigated whether susceptibility loci for the diabetes would increase the risk of BPH development and progression in Chinese elderly men. Material and Methods: Fifteen SNPs associated with the diabetes risk in a Chinese population were genotyped in 377 BPH cases (152 aggressive and 225 non-aggressive BPH cases) and 1,008 controls. The association between the SNPs and risk of BPH development was evaluated through logistic regression. Additionally, effects of the 15 SNPs on BPH related clinical parameters, including body mass index (BMI) International Prostate Symptom Score (IPSS), Quality of Life (QoL) and prostate volume (PV) were also evaluated. Results: SNP rs9864104 in IGF2BP2 at 3q27 (OR=1.24, P =0.0148) was significantly associated with BPH development. In addition, SNP rs9863780, rs9864104, rs10229583 and rs17727841 were significantly associated with baseline clinical parameters in BPH patients. Moreover, the risk allele of rs6763887 (C) and rs17727841 (C) were significantly associated with the change of storage score and voiding score after treatment. No SNPs was associated with the risk of BPH progression. Conclusions: This is a systematic investigation on the contributions of diabetes susceptibility loci to risk of BPH development and progression. Our findings advance the understanding of the genetic basis of BPH and provide new insights into the genetic determinants shared between BPH and metabolic syndrome.

Sign in / Sign up

Export Citation Format

Share Document