O006: IDO activity forecasts obesity in females in 10-year follow-up study: the Cardiovascular Risk in Young Finns study

2019 ◽  
Vol 175 ◽  
pp. S2-S3
Author(s):  
P. Niinisalo ◽  
O.T. Raitakari ◽  
M. Kähönen ◽  
J. Viikari ◽  
M. Juonala ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Follow Up Study ◽  
Young Finns Study

scholarly journals Sweets and sugar-sweetened soft drink intake in childhood in relation to adult BMI and overweight. The Cardiovascular Risk in Young Finns Study

2009 ◽  
Vol 12 (11) ◽  
pp. 2018-2026 ◽  
Author(s):  
Katja Nissinen ◽  
Vera Mikkilä ◽  
Satu Männistö ◽  
Marjaana Lahti-Koski ◽  
Leena Räsänen ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Children And Adolescents ◽  
Weight Management ◽  
Soft Drink ◽  
Soft Drinks ◽  
Childhood And Adolescence ◽  
Follow Up Study ◽  
Unit Increase ◽  
Young Finns Study

AbstractObjectiveTo investigate the associations of BMI and overweight in adulthood with consumption of sweets and sugar-sweetened soft drinks in childhood and with the change in consumption between childhood and adulthood.DesignLongitudinal 21-year follow-up study of Finnish children and adolescents from childhood to adulthood.SettingThe Cardiovascular Risk in Young Finns Study, comprising participants from both eastern and western Finland.SubjectsBoys (n967) and girls (n1172) aged 3–18 years at baseline in 1980.ResultsThe increase in consumption of sugar-sweetened soft drinks from childhood to adulthood was directly associated with BMI in adulthood in women (b= 0·45,P= 0·0001) but not in men. In women, BMI increased by 0·45 kg/m2for every 10-unit increase per month. Consumption of sweets and sugar-sweetened soft drinks in childhood and adolescence was not associated with BMI in adulthood. The change in consumption of sweets was not associated with BMI in adulthood. The increase in the consumption of sugar-sweetened soft drinks from childhood to adulthood was associated with being overweight (OR = 1·90, 95 % CI 1·38, 2·61) in women, but not in men. No association was found between overweight (BMI ≥ 25 kg/m2) in adulthood and consumption of sweets in childhood or the change in consumption from childhood to adulthood.ConclusionsWe conclude that direct associations exist between adulthood overweight and BMI and an increase in consumption of sugar-sweetened soft drinks in women. Thus sugar-sweetened soft drinks consumption may be important when considering weight management in women.

P3462IDO activity forecasts obesity in premenopausal females in 10-year follow-up study: the Cardiovascular Risk in Young Finns Study

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
P Niinisalo ◽  
O T Raitakari ◽  
M Kahonen ◽  
J Viikari ◽  
M Juonala ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Cardiovascular Risk ◽  
Study Patient ◽  
Specific Marker ◽  
Intracellular Enzyme ◽  
Follow Up Study ◽  
The Relationship ◽  
Young Finns Study

Abstract Background Indoleamine 2,3-dioxygenase (IDO) is an intracellular enzyme that has an important immunomodulator function. Human inflammatory response promotes upregulation of IDO level in blood. This may lead to suppression of inflammation in atherosclerotic vessel wall and consequently may slow the progression of the disease. Previous studies have shown that IDO activity correlates with early signs of atherosclerosis especially in females but is not an atherosclerosis-specific marker. Materials and methods IDO levels were measured from females (n=544; age 24–39; weight 40.5–134.4 kg) in 2001 along with several risk factors for atherosclerosis. Follow-up risk factor measurements were performed in 2007 and 2011. Here we aimed to elucidate the relationship between IDO measurements from 2001 and several atherosclerotic risk factors from 2007 and 2011 by analyzing correlations and risk ratios from the Cardiovascular Risk in Young Finns Study patient cohort. Results After age standardization, IDO correlated significantly with BMI (p=0.0008), waist (p=0.0009) and logarithmically modified triglycerides (p=0.0488) and CRP (p=0.0014) in female samples (n=434) from 2007. When female samples (n=384) from 2011 were examined, statistically significant correlations were discovered in BMI and Waist in both unadjusted (p<0.0001 and 0.0003, respectively) and age-adjusted analysis (p=0.0007 and 0.006, respectively). In contrast, only weak correlations were found in male samples. In risk ratio analysis IDO promoted obesity (RR=1.027, p=0.01) in females (n=431) in 10-year follow-up study even after the data was adjusted for age, CRP and BMI. Conclusions It is concluded that IDO activity forecasts obesity – a well-characterized risk factor for diabetes and atherosclerosis – in premenopausal females.

scholarly journals The 21-year follow-up of the Cardiovascular Risk in Young Finns Study: risk factor levels, secular trends and east-west difference

2004 ◽  
Vol 255 (4) ◽  
pp. 457-468 ◽  
Author(s):  
M. Juonala ◽  
J. S. A. Viikari ◽  
N. Hutri-Kahonen ◽  
M. Pietikainen ◽  
E. Jokinen ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cardiovascular Risk ◽  
Secular Trends ◽  
Study Risk Factor ◽  
East West ◽  
Young Finns Study

scholarly journals HDL cholesterol efflux capacity is inversely associated with subclinical cardiovascular risk markers in young adults: The cardiovascular risk in Young Finns study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Monika Hunjadi ◽  
Claudia Lamina ◽  
Patrick Kahler ◽  
Tamara Bernscherer ◽  
Jorma Viikari ◽  
...  
Keyword(s):  
Young Adults ◽  
Cardiovascular Risk ◽  
Cholesterol Efflux ◽  
Subclinical Atherosclerosis ◽  
Structure And Function ◽  
Risk Markers ◽  
Arterial Structure ◽  
And Function ◽  
Young Finns Study

Abstract The atherogenic process begins already in childhood and progresses to symptomatic condition with age. We investigated the association of cholesterol efflux capacity (CEC) and vascular markers of subclinical atherosclerosis in healthy, young adults. CEC was determined in 2282 participants of the Young Finns study using cAMP treated 3H-cholesterol-labeled J774 cells. The CEC was correlated to baseline and 6-year follow-up data of cardiovascular risk factors and ultrasound measurements of arterial structure and function. CEC was higher in women, correlated with total cholesterol, HDL-C, and apolipoprotein A-I, but not with LDL-C or apolipoprotein B. Compared to the lowest CEC quartile, the highest CEC quartile was significantly associated with high CRP levels and inversely associated with adiponectin. At baseline, high CEC was associated with decreased flow-mediated dilation (FMD) and carotid artery distensibility, as well as an increased Young's modulus of elasticity, indicating adverse changes in arterial structure, and function. The association reversed with follow-up FMD data, indicating the interaction of preclinical parameters over time. A higher CEC was directly associated with a lower risk of subclinical atherosclerosis at follow-up. In young and healthy subjects, CEC was associated with important lipid risk parameters at baseline, as in older patients and CAD patients, but inversely with early risk markers for subclinical atherosclerosis.

Bariatric Surgery‐Induced Changes in Intima‐Media Thickness and Cardiovascular Risk Factors in Class 3 Obesity: A 3‐Year Follow‐Up Study

Obesity ◽  
2020 ◽  
Vol 28 (9) ◽  
pp. 1663-1670
Author(s):  
Blanca Domenech‐Ximenos ◽  
Victor Cuba ◽  
Pepus Daunis‐i‐Estadella ◽  
Santiago Thió‐Henestrosa ◽  
Francisco Jaldo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bariatric Surgery ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Intima Media Thickness ◽  
Follow Up Study ◽  
Media Thickness ◽  
Induced Changes

Has brief counselling an impact on the risk factors for cardiovascular disease in 40-year-old men. A three-year follow-up study

Open Medicine ◽  
2008 ◽  
Vol 3 (3) ◽  
pp. 300-307 ◽  
Author(s):  
Anita Näslindh-Ylispangar ◽  
Marja Sihvonen ◽  
Seppo Sarna ◽  
Hannu Vanhanen ◽  
Pertti Kekki
Keyword(s):  
Risk Factors ◽  
Health Care ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Repeated Measures ◽  
Follow Up Study ◽  
The Metabolic Syndrome ◽  
Old Men ◽  
The Impact

AbstractThe metabolic syndrome presents a serious challenge to health professionals. The aim of the present study is to analyze the impact of a brief counselling on cardiovascular risk factors among 40-year-old men. Forty-six males living in north-eastern Helsinki voluntarily completed the follow-up study between 2001 and 2004, and were assessed for clinical risk factors. The mean differences were determined by a paired t-test, and the interaction between groups and time by the F-test with repeated measures ANOVA. After baseline assessment and in 2002, males received a 45 minute nurse-delivered counselling session with self-administered protocol. Cardiovascular risk factors improved significantly (p<0.05) from baseline within months. However, the final measurements obtained after three years showed that almost all risk factors, except the low and high density lipoprotein, tended to revert back to baseline. The profiles were similar in all predictor groups. Brief counselling had an impact on risk factors measured in 2002, but only a partial effect on them in 2004. Conclusive results lead to the idea thatmore collaboration is needed between private health care agencies and official primary health care for ensuring the continuity of improved health habits among middle-aged males.

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