Blistering Mucocutaneous Diseases of the Oral Mucosa—A Review: Part 2. Pemphigus Vulgaris

2007 ◽  
Vol 2007 ◽  
pp. 162-163
Author(s):  
D.P. Lynch
Keyword(s):  
Oral Mucosa ◽  
Pemphigus Vulgaris

scholarly journals The research of the state of prosthetic bed tissues in patients with pemphigus vulgaris.

2017 ◽  
Vol 23 (1) ◽  
Author(s):  
Bohdan Lyubomyrovych Henyk ◽  
Mykola Mykhaylovych Rozko
Keyword(s):  
Survey Data ◽  
Oral Mucosa ◽  
Clinical Examination ◽  
Comparative Evaluation ◽  
Objective Assessment ◽  
Pemphigus Vulgaris ◽  
The State ◽  
Control Group

The clinical examination of condition of tissues prosthetic bed was conducted in 20 patients with  pemphigus vulgaris. The results are compared with survey data of 20 persons of control group without somatic pathology. It was conducted the analyzes of subjective and objective assessment of tissues prosthetic bed, the results of clinical examination and frequency of various pathologies of the oral mucosa membrane in the studied groups, conducted the comparative evaluation of dental indicators.

scholarly journals Optical coherence tomography imaging of oral mucosa bullous diseases: a preliminary study

2020 ◽  
Vol 49 (2) ◽  
pp. 20190071
Author(s):  
Dario Di Stasio ◽  
Dorina Lauritano ◽  
Francesca Loffredo ◽  
Enrica Gentile ◽  
Fedora Della Vella ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Oral Mucosa ◽  
Statistical Power ◽  
Pemphigus Vulgaris ◽  
Invasive Technique ◽  
Optical Coherence ◽  
Non Invasive ◽  
Bullous Diseases ◽  
Subepithelial Layer

Objectives: Optical coherence tomography (OCT) is a non-invasive technique based on optical imaging with a micrometre resolution. The purpose of this study is to investigate the potential role of OCT in evaluating oral mucosa bullous diseases. Methods: two patients with bullous pemphigoid (BP) and one patient with pemphigus vulgaris (PV) were examined and images of their oral lesions were performed using OCT. Results: In OCT images, the BP blister has a clearly different morphology from the PV one compared to the blistering level. Conclusion: This exploratory study suggests that the OCT is able to distinguish epithelial and subepithelial layer in vivo images of healthy oral mucosa from those with bullous diseases, assisting the clinicians in differential diagnosis.The presented data are in accordance with the scientific literature, although a wider pool of cases is needed to increase statistical power. Histological examination and immunofluorescence methods remain the gold standard for the diagnosis of oral bullous diseases. In this context, the OCT can provide the clinician with a valuable aid both as an additional diagnostic tool and in the follow up of the disease.

scholarly journals A case of pemphigus vulgaris of the oral mucosa that responded to double-filtration plasmapheresis

2006 ◽  
Vol 52 (10) ◽  
pp. 556-559
Author(s):  
Miki ISHIBASHI ◽  
Kazuma NOGUCHI ◽  
Norio MASUDA ◽  
Kazunari SAKURAI ◽  
Masahiro URADE
Keyword(s):  
Oral Mucosa ◽  
Pemphigus Vulgaris ◽  
Double Filtration Plasmapheresis ◽  
Double Filtration

scholarly journals Autoimmune diseases of oral cavity

2011 ◽  
Vol 2 (2) ◽  
pp. 113-136 ◽  
Author(s):  
Davide B. Gissi ◽  
Mattia Venturi ◽  
Andrea Gabusi ◽  
Annachiara De Martino ◽  
Lucio Montebugnoli
Keyword(s):  
Oral Mucosa ◽  
Pemphigus Vulgaris ◽  
Definitive Diagnosis ◽  
Recurrent Aphthous Stomatitis ◽  
Accurate Diagnosis ◽  
Mucous Membrane Pemphigoid ◽  
Oral Manifestations ◽  
Therapeutic Approaches ◽  
Intercellular Adhesion Molecules ◽  
Bullous Diseases

Most diseases of oral mucosa are either autoimmune in nature or are the results of immunologically-mediated events. These include Recurrent Aphthous Stomatitis (RAS), Erythema Multiforme (EM), the bullous diseases Pemphigus Vulgaris (PV) and Mucous Membrane Pemphigoid (MMP) and Lichen Planus (LP). These conditions are characterised by lesions of the oral mucosa often associated with extra-oral manifestations that include skin, eyes, nasal and pharyngeal mucosa as well as genitals. Despite a similar pathogenesis, they are characterised by different immunologic processes that involve T-cell mediated hypersensitivity in LP, humoral-mediated immunity to cadherin intercellular adhesion molecules in PV, antibody-mediated processes giving rise to junctional separation in MMP, and other not yet completely understood processes in RAS and EM. Differences are also present in the clinical outcome, that is always acute and auto-limiting in EM, auto-limiting and often recurrent in RAS, sub-acute and often recurrent in MMP and PV and always chronic in LP. Accurate diagnosis is not always possible solely on the basis of the oral presentation, and histological and often immunofluorescence examinations are needed in order to establish a definitive diagnosis. The condition that brings together all these diseases is that thay all benefit from similar therapeutic approaches, consisting in local or systemic immunosuppressive treatments. This review provides guidance to differentiate and correctly diagnose these conditions and discusses the most appropriate management.

scholarly journals Utility of oral mucosa as a substrate for the serodiagnosis of pemphigus: A descriptive analysis

2021 ◽  
Vol 0 ◽  
pp. 1-6
Author(s):  
Anuradha Jindal ◽  
Chythra Rao ◽  
Satish B. Pai ◽  
Raghavendra Rao
Keyword(s):  
Human Skin ◽  
Oral Mucosa ◽  
Immunosorbent Assay ◽  
Indirect Immunofluorescence ◽  
Pemphigus Vulgaris ◽  
Enzyme Linked Immunosorbent Assay ◽  
Pemphigus Foliaceus ◽  
Normal Human Skin ◽  
Normal Human ◽  
Monkey Esophagus

Background: The indirect immunofluorescence test is useful in the serodiagnosis of pemphigus. As indirect immunofluorescence titers correlate with disease activity in pemphigus, it is often used as a monitoring tool. The sensitivity of indirect immunofluorescence depends on the substrate used, and the preferred substrates are monkey esophagus for pemphigus vulgaris and normal human skin for pemphigus foliaceus. Aims: We evaluated oral mucosa as a substrate for indirect immunofluorescence in pemphigus. Methods: Fifty patients with pemphigus (40 with pemphigus vulgaris and ten with pemphigus foliaceus) and 50 controls were enrolled for study. Demographic and clinical details were recorded and indirect immunofluorescence using two substrates (oral mucosa and normal human skin) was carried out in serial dilution. Desmoglein (Dsg) 1 and 3 enzyme-linked immunosorbent assay was also evaluated simultaneously. Results: Indirect immunofluorescence was positive in 40 patients (80%) with oral mucosa substrate and 34 patients (68%) with normal human skin substrate. Circulating antibodies were detected with oral mucosa in 33 (82.5%) of the 40 pemphigus vulgaris patients and in 26 (65%) patients using normal human skin. Antibodies were detected in eight of the ten pemphigus foliaceus patients (80%) with normal human skin and in seven (70%) patients with oral mucosa. Dsg enzyme-linked immunosorbent assay was positive in 45 (90%) patients, and 37 of these were also indirect immunofluorescence positive with oral mucosa. In the five Dsg enzyme-linked immunosorbent assay-negative patients, indirect immunofluorescence with oral mucosa was positive in three. Limitations: A comparison of oral mucosa with monkey esophagus could not be performed. Conclusion: Oral mucosa is a suitable and sensitive substrate for indirect immunofluorescence in pemphigus. Further studies comparing the sensitivity of indirect immunofluorescence using oral mucosa with monkey esophagus are recommended.

scholarly journals Phemphigus vulgaris an autoimmune acantholysis: a case report

2020 ◽  
Vol 6 (6) ◽  
pp. 801
Author(s):  
Abarna Lakshmi Ravi ◽  
Rajganesh Ravichandran ◽  
Nikhil Cherian Sam ◽  
Jaya Shree Dilibatcha ◽  
Raveena Pachal Balakrishnan
Keyword(s):  
Monoclonal Antibodies ◽  
Case Report ◽  
Oral Mucosa ◽  
Male Patient ◽  
Skin Disease ◽  
Pemphigus Vulgaris ◽  
Good Recovery ◽  
Clear Fluid ◽  
The Face ◽  
Epithelial Layers

<p class="abstract">Pemphigus vulgaris is a rare chronic autoimmune skin disease characterized by a flaccid blister filled with clear fluid that arises on the skin or an erythematous base. The keratinocytes separated by the desmoglein present on the desmosomes which clinically manifests as fluid-filled blisters on the skin. We present pemphigus vulgaris with an unknown cause but good recovery after the management with monoclonal antibodies and corticosteroids in a 30-year-old male patient who came to the hospital with complaints of blisters on the epithelial layers of skin on the face and oral mucosa.</p>

Case of pemphigus vulgaris in oral mucosa showing an extension to the body surface with recurrent varicella

2005 ◽  
Vol 44 (11) ◽  
pp. 951-954 ◽  
Author(s):  
Yuji Horiguchi ◽  
Shinobu Fujii ◽  
Sawako Takase ◽  
Ryoko Mori
Keyword(s):  
Oral Mucosa ◽  
Body Surface ◽  
Pemphigus Vulgaris ◽  
The Body

Differential Diagnosis of Superficial Ulcerations of the Oral Mucosa

1979 ◽  
Vol 87 (6) ◽  
pp. 734-740 ◽  
Author(s):  
Richard A. Chole ◽  
George H. Domb
Keyword(s):  
Differential Diagnosis ◽  
Oral Mucosa ◽  
Verrucous Carcinoma ◽  
Pemphigus Vulgaris ◽  
The Body ◽  
Stevens Johnson Syndrome ◽  
Mucous Membrane Pemphigoid ◽  
Diagnostic Challenge ◽  
Johnson Syndrome ◽  
Herpetic Gingivostomatitis

Superficial ulcerations of the oral mucosa often present a diagnostic challenge to the physician because of the similarity of one ulcer to another. A diagnosis is made by the analysis of multiple factors, including the lesion's location, size, grouping, onset, patient's age, involvement of other systems of the body, and course of the disease. The histopathology of the lesion may be specific, especially in certain potentially fatal diseases. This paper presents the means for the differential diagnosis of a variety of superficial ulcers of the oral mucosa: varicella, herpangina, recurrent aphthous stomatitis, Behcet's disease, Stevens-Johnson syndrome, traumatic ulcer, verrucous carcinoma, primary herpetic gingivostomatitis, recurrent herpetic stomatitis, pemphigus vulgaris, and benign mucous membrane pemphigoid.

An Overview of Vesicobullous Conditions Affecting the Oral Mucosa

2016 ◽  
Vol 5 (1) ◽  
pp. 46-50 ◽  
Author(s):  
Emma Hayes ◽  
Stephen J Challacombe
Keyword(s):  
Learning Outcomes ◽  
Oral Mucosa ◽  
Clinical Presentation ◽  
Pemphigus Vulgaris ◽  
Basement Membrane Zone ◽  
Mucous Membrane Pemphigoid ◽  
Specific Reference ◽  
Common Presentation ◽  
The Common

Vesicobullous diseases are characterised by the presence of vesicles or bullae at varying locations in the mucosa. The most common occurring in the oral cavity are mucous membrane pemphigoid (MMP) and pemphigus vulgaris (PV). Both are autoimmune diseases with a peak age onset of over 60 years and females are more commonly affected than men. This paper reviews the structure of the oral mucosa, with specific reference to the basement membrane zone, as well as bullous conditions affecting the mucosa, including PV and pemphigoid, their aetiology, clinical presentation, and management. Learning outcomes • Understand the common presentation of vesicobullous diseases. • Appreciate the role of investigations in diagnosis and its interpretation. • Appreciate the roles of both primary and secondary care in patient management.

scholarly journals Mucosal Pemphigus Vulgaris Anti-Dsg3 IgG Is Pathogenic to the Oral Mucosa of Humanized Dsg3 Mice

2015 ◽  
Vol 135 (6) ◽  
pp. 1590-1597 ◽  
Author(s):  
Donna A. Culton ◽  
Suzanne K. McCray ◽  
Moonhee Park ◽  
James C. Roberts ◽  
Ning Li ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Pemphigus Vulgaris
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