An Overview of Vesicobullous Conditions Affecting the Oral Mucosa

2016 ◽  
Vol 5 (1) ◽  
pp. 46-50 ◽  
Author(s):  
Emma Hayes ◽  
Stephen J Challacombe
Keyword(s):  
Learning Outcomes ◽  
Oral Mucosa ◽  
Clinical Presentation ◽  
Pemphigus Vulgaris ◽  
Basement Membrane Zone ◽  
Mucous Membrane Pemphigoid ◽  
Specific Reference ◽  
Common Presentation ◽  
The Common

Vesicobullous diseases are characterised by the presence of vesicles or bullae at varying locations in the mucosa. The most common occurring in the oral cavity are mucous membrane pemphigoid (MMP) and pemphigus vulgaris (PV). Both are autoimmune diseases with a peak age onset of over 60 years and females are more commonly affected than men. This paper reviews the structure of the oral mucosa, with specific reference to the basement membrane zone, as well as bullous conditions affecting the mucosa, including PV and pemphigoid, their aetiology, clinical presentation, and management. Learning outcomes • Understand the common presentation of vesicobullous diseases. • Appreciate the role of investigations in diagnosis and its interpretation. • Appreciate the roles of both primary and secondary care in patient management.

Maimonides’s Rationalization of the Incest Taboo, Its Reception in Thirteenth-Century Kabbalah, and Their Affinity to Aquinas

2021 ◽  
Vol 114 (3) ◽  
pp. 371-392
Author(s):  
Leore Sachs-Shmueli
Keyword(s):  
Thirteenth Century ◽  
Incest Taboo ◽  
Common Presentation ◽  
The Common ◽  
Jewish Philosophy

AbstractThis article discusses Maimonides’s rationale for the incest taboo and traces its reception in Christian and kabbalistic traditions in the thirteenth century. Tracing the reception of Maimonides’s view enables recognition of the resemblance between Maimonides and Aquinas, the ambivalent stance toward Maimonides’s explanation expressed by Nahmanides, and the incorporation of Maimonides’s reasoning in one of the most systematic and enigmatic works of kabbalistic rationalization of the commandments, the Castilian Kabbalist Joseph of Hamadan’s The Book of the Rationales of the Negative Commandments. R. Joseph’s acceptance of Maimonidean principles and his integration of them in the theurgic Kabbalah reveal a conflict in the heart of its system and teach us about an important aspect of the theory of sexuality in Kabbalah. The inquiry offered here examines the inter-relations between divergent medieval religious trends in constructing the role of sexuality. Instead of the common presentation of Kabbalah as diverging from the ascetic positions of Jewish philosophy and Christianity, this analysis will elucidate Kabbalah’s continuity with them.

scholarly journals Social cohesion and social capital: Possible implications for the common good

2014 ◽  
Vol 35 (3) ◽  
Author(s):  
Anita Cloete
Keyword(s):  
Social Capital ◽  
South African ◽  
Social Cohesion ◽  
Common Good ◽  
Specific Reference ◽  
The Common Good ◽  
Bridging Social Capital ◽  
African Context ◽  
The Common

The main objective of the article is to identify the possible implications of social cohesion and social capital for the common good. In order to reach this overarching aim the following structure will be utilised. The first part explores the conceptual understanding of socialcohesion and social capital in order to establish how these concepts are related and how they could possibly inform each other. The contextual nature of social cohesion and social capital is briefly reflected upon, with specific reference to the South African context. The contribution of religious capital in the formation of social capital is explored in the last section of the article. The article could be viewed as mainly conceptual and explorative in nature in order to draw some conclusions about the common good of social capital and social cohesion.Intradisciplinary and/or interdisciplinary implications: This article contributes to the interdisciplinary discourse on social cohesion with specific reference to the role of congregations. It provides a critical reflection on the role of congregations with regard to bonding and bridging social capital. The contextual nature of social cohesion is also addressed with specific reference to South Africa.

Bullous disorders

2018 ◽  
Author(s):  
Emily Davies
Keyword(s):  
Basement Membrane ◽  
Dermatitis Herpetiformis ◽  
Pemphigus Vulgaris ◽  
Basement Membrane Zone ◽  
Mucous Membrane Pemphigoid ◽  
Pemphigus Foliaceus ◽  
Pemphigoid Gestationis ◽  
Bullous Disease ◽  
Adhesion Junctions ◽  
Linear Iga Disease

This chapter focuses on immunobullous diseases. The immunobullous disorders are a group of diseases in which pathogenic autoantibodies bind to target antigens either in desmosomes (intra-epidermal intracellular adhesion junctions) or in part of the basement membrane zone, resulting in loss of adhesion, and blister formation. This chapter will focus on pemphigus vulgaris, pemphigus foliaceus, bullous pemphigoid, linear IgA disease, chronic bullous disease of childhood, and dermatitis herpetiformis; it will also mention mucous membrane pemphigoid, pemphigoid gestationis, and epidermolysis bullosa acquisita.

scholarly journals Autoimmune diseases of oral cavity

2011 ◽  
Vol 2 (2) ◽  
pp. 113-136 ◽  
Author(s):  
Davide B. Gissi ◽  
Mattia Venturi ◽  
Andrea Gabusi ◽  
Annachiara De Martino ◽  
Lucio Montebugnoli
Keyword(s):  
Oral Mucosa ◽  
Pemphigus Vulgaris ◽  
Definitive Diagnosis ◽  
Recurrent Aphthous Stomatitis ◽  
Accurate Diagnosis ◽  
Mucous Membrane Pemphigoid ◽  
Oral Manifestations ◽  
Therapeutic Approaches ◽  
Intercellular Adhesion Molecules ◽  
Bullous Diseases

Most diseases of oral mucosa are either autoimmune in nature or are the results of immunologically-mediated events. These include Recurrent Aphthous Stomatitis (RAS), Erythema Multiforme (EM), the bullous diseases Pemphigus Vulgaris (PV) and Mucous Membrane Pemphigoid (MMP) and Lichen Planus (LP). These conditions are characterised by lesions of the oral mucosa often associated with extra-oral manifestations that include skin, eyes, nasal and pharyngeal mucosa as well as genitals. Despite a similar pathogenesis, they are characterised by different immunologic processes that involve T-cell mediated hypersensitivity in LP, humoral-mediated immunity to cadherin intercellular adhesion molecules in PV, antibody-mediated processes giving rise to junctional separation in MMP, and other not yet completely understood processes in RAS and EM. Differences are also present in the clinical outcome, that is always acute and auto-limiting in EM, auto-limiting and often recurrent in RAS, sub-acute and often recurrent in MMP and PV and always chronic in LP. Accurate diagnosis is not always possible solely on the basis of the oral presentation, and histological and often immunofluorescence examinations are needed in order to establish a definitive diagnosis. The condition that brings together all these diseases is that thay all benefit from similar therapeutic approaches, consisting in local or systemic immunosuppressive treatments. This review provides guidance to differentiate and correctly diagnose these conditions and discusses the most appropriate management.

Differential Diagnosis of Superficial Ulcerations of the Oral Mucosa

1979 ◽  
Vol 87 (6) ◽  
pp. 734-740 ◽  
Author(s):  
Richard A. Chole ◽  
George H. Domb
Keyword(s):  
Differential Diagnosis ◽  
Oral Mucosa ◽  
Verrucous Carcinoma ◽  
Pemphigus Vulgaris ◽  
The Body ◽  
Stevens Johnson Syndrome ◽  
Mucous Membrane Pemphigoid ◽  
Diagnostic Challenge ◽  
Johnson Syndrome ◽  
Herpetic Gingivostomatitis

Superficial ulcerations of the oral mucosa often present a diagnostic challenge to the physician because of the similarity of one ulcer to another. A diagnosis is made by the analysis of multiple factors, including the lesion's location, size, grouping, onset, patient's age, involvement of other systems of the body, and course of the disease. The histopathology of the lesion may be specific, especially in certain potentially fatal diseases. This paper presents the means for the differential diagnosis of a variety of superficial ulcers of the oral mucosa: varicella, herpangina, recurrent aphthous stomatitis, Behcet's disease, Stevens-Johnson syndrome, traumatic ulcer, verrucous carcinoma, primary herpetic gingivostomatitis, recurrent herpetic stomatitis, pemphigus vulgaris, and benign mucous membrane pemphigoid.

scholarly journals ECTOPIC PREGNANCY

2007 ◽  
Vol 14 (01) ◽  
pp. 186-189
Author(s):  
SAIMA QURESHI ◽  
MAHNAAZ ROOHI ◽  
TASNIM TAHIRA
Keyword(s):  
Early Diagnosis ◽  
Ectopic Pregnancy ◽  
Clinical Presentation ◽  
Detailed History ◽  
Common Presentation ◽  
Period 2 ◽  
The Common

Objective: 1-To know the common presentation of ectopic pregnancy attended during the study period. 2- To find out that how clinical presentation helps in early diagnosis of ectopic pregnancy. Settings: Department of Obstetrics & Gynecology Unit # 1 Allied Hospital Faisalabad. Period: From 01-01-02 to 01-01-04. Patients, Methods, Results: Eighty five patients were included in study attended the emergency or outpatients of Allied Hospital Faisalabad. Detailed history, clinical examinations and investigations like urine for & ultrasonography used for diagnosis. 52% cases were presented in acute way. 48% were sub acute presentations. 96% patients required salpingectomy. Conclusion: Management of Ectopic Pregnancy is by far salpingectomy because our patients usually attend late that is in acute way.

An Overview of Dementias

2012 ◽  
Vol 21 (3) ◽  
pp. 75-84
Author(s):  
Venkata Vijaya K. Dalai ◽  
Jason E. Childress ◽  
Paul E Schulz
Keyword(s):  
Clinical Presentation ◽  
Treatment Options ◽  
Current Treatment ◽  
Great Variability ◽  
Health Concern ◽  
Public Health Concern ◽  
Life Threatening ◽  
The Common ◽  
Neurodegenerative Dementias ◽  
Made In

Dementia is a major public health concern that afflicts an estimated 24.3 million people worldwide. Great strides are being made in order to better diagnose, prevent, and treat these disorders. Dementia is associated with multiple complications, some of which can be life-threatening, such as dysphagia. There is great variability between dementias in terms of when dysphagia and other swallowing disorders occur. In order to prepare the reader for the other articles in this publication discussing swallowing issues in depth, the authors of this article will provide a brief overview of the prevalence, risk factors, pathogenesis, clinical presentation, diagnosis, current treatment options, and implications for eating for the common forms of neurodegenerative dementias.

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