Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles

The Lancet ◽  
2004 ◽  
Vol 363 (9411) ◽  
pp. 775-781 ◽  
Author(s):  
Michael H Jones ◽  
Carl Virtanen ◽  
Daisuke Honjoh ◽  
Tatsu Miyoshi ◽  
Yukitoshi Satoh ◽  
...  
Keyword(s):  
Gene Expression ◽  
Neuroendocrine Tumours ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Large Cell ◽  
Small Cell ◽  
High Grade ◽  
Neuroendocrine Carcinomas

An identification of stem cell-resembling gene expression profiles in high-grade astrocytomas

2008 ◽  
Vol 47 (11) ◽  
pp. 893-903 ◽  
Author(s):  
Yang Yang ◽  
Yongming Qiu ◽  
Wenwen Ren ◽  
Jialei Gong ◽  
Fuxue Chen
Keyword(s):  
Gene Expression ◽  
Stem Cell ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
High Grade

Corrigendum to “Phenotypic mismatch repair hMSH2 and hMLH1 gene expression profiles in primary non-small cell lung carcinomas” [Lung Cancer 64 (2009) 282–288]

Lung Cancer ◽  
2010 ◽  
Vol 67 (1) ◽  
pp. 126
Author(s):  
Dimitra Vageli ◽  
Zoe Daniil ◽  
Jubrail Dahabreh ◽  
Eleni Karagianni ◽  
Dimitra N. Vamvakopoulou ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Mismatch Repair ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Carcinomas ◽  
Hmlh1 Gene

Gene expression profiles in non-small cell lung cancers (NSCLCs) and in corresponding healthy lung tissues in smokers versus nonsmokers.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. 1545-1545
Author(s):  
A. Szymanowska-Narloch ◽  
M. Skrzypski ◽  
M. Taron ◽  
H. Dienemann ◽  
W. Rzyman ◽  
...  
Keyword(s):  
Gene Expression ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancers ◽  
Healthy Lung

scholarly journals Over-expression of the kayopherin 𝛂2 gene (KPNA2) in high-grade serous ovarian cancers.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Gene Expression ◽  
Ovarian Cancer ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
High Grade ◽  
Over Expression ◽  
Ovarian Cancers ◽  
Microarray Datasets

Ovarian cancer is the most lethal gynecologic malignancy and 70-80% of ovarian cancers are of the high-grade serous type (1-3). To identify the most significant changes in gene expression in high-grade serous ovarian cancer (HGSC), we compared global gene expression profiles of tumors from patients with HGSC to that of normal ovary using published microarray datasets (4, 5). We found that the nuclear import receptor karyopherin 𝛂2 (KPNA2) (6) was among the genes whose expression changed most significantly when comparing HSGC tumors to the ovary. Karyopherin 𝛂2 may be relevant to the biology of high-grade serous ovarian tumors.

Comparative Outcomes in Patients With Small- and Large-Cell Neuroendocrine Carcinoma (NEC) and Mixed Neuroendocrine-Non-Neuroendocrine Neoplasm (MiNEN) of the Stomach

2020 ◽  
pp. 000313482095000
Author(s):  
Nam Young Choi ◽  
Byung-Sik Kim ◽  
Sung Tae Oh ◽  
Jeong Hwan Yook ◽  
Beom Su Kim
Keyword(s):  
Clinical Outcomes ◽  
Disease Free Survival ◽  
Large Cell ◽  
Small Cell ◽  
Neuroendocrine Neoplasm ◽  
Neuroendocrine Neoplasms ◽  
High Grade ◽  
Intermediate Grade ◽  
Free Survival ◽  
Neuroendocrine Carcinomas

Background Gastric neuroendocrine carcinomas (NECs), consisting of both large- and small-cell NECs, and mixed adenoneuroendocrine carcinomas (MANECs), including mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs), are a group of high-grade malignancies. Few studies to date have reported clinical outcomes, including prognosis, in patients with these tumors. This study therefore evaluated the clinicopathologic outcomes and prognosis in patients with NECs and MANECs. Methods This study included 36 patients diagnosed with gastric NECs, including 23 with large-cell and 13 with small-cell NECs, and 85 with MiNENs, including 70 with high-grade and 15 with intermediate-grade MiNENs. Clinical outcomes, including overall survival (OS) and disease-free survival (DFS), were assessed. Results DFS was significantly poorer in patients with NEC than in patients with intermediate-grade MiNEN ( P < .05), whereas both OS and DFS were similar in patients with NEC and high-grade MiNEN ( P > .05). Patients with large-cell NEC were more likely to undergo aggressive surgery than patients with high-grade MiNEN ( P < .05). Lymphovascular invasion was more frequent and DFS poorer in patients with large-cell than small-cell NECs ( P < .05 each). Conclusion DFS is significantly poorer in patients with NEC than in patients with intermediate-grade MiNEN and significantly lower in patients with large-cell than small-cell NECs.

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