Causes of cancer in the world: comparative risk assessment of nine behavioural and environmental risk factors

The Lancet ◽  
2005 ◽  
Vol 366 (9499) ◽  
pp. 1784-1793 ◽  
Author(s):  
Goodarz Danaei ◽  
Stephen Vander Hoorn ◽  
Alan D Lopez ◽  
Christopher JL Murray ◽  
Majid Ezzati
Author(s):  
Peter Chemweno ◽  
Liliane Pintelon

Abstract Dialysis processes within the home care context is associated with risk factors which are not very prominent in the hospital context. This includes risk factors such as unanticipated device malfunction, or erroneous operation of the equipment, which exposes the patient to injury while undergoing dialysis. Importantly, the mentioned risk factors are further attributed to technical aspects such as sub-optimal equipment maintenance or following improper clinical procedures when administering care to the patient. Hence, it is important to follow a methodological approach to identify and assess hazards embedded within the dialysis treatment process, and on this basis, formulate effective strategies to mitigate their negative consequences on patient safety. This paper presents a comparative risk assessment for in-hospital versus in-home dialysis care. For the two cases, the risk assessment considers expertise of care givers involved in administering dialysis. The findings show that performing risk assessment for hospital environment, is more structured owing to expertise of clinicians and care givers responsible for administering dialysis. However, assessing risks for the home-care environment is more challenging owing to absence of domain knowledge, hence a survey approach to structure the risk assessment process is necessary. Moreover, risks in the home care context is influenced by logistical aspects, and lack of domain knowledge for maintaining dialysis equipment. Overall, insights from the comparative studies yields important learning points expected to improve dialysis care as more healthcare providers transfer care to the home environment.


The Lancet ◽  
2013 ◽  
Vol 381 ◽  
pp. S47 ◽  
Author(s):  
Farshad Farzadfar ◽  
Goodarz Danaei ◽  
Hengameh Namdaritabar ◽  
Julie Knoll Rajaratnam ◽  
Jacob R Marcus ◽  
...  

PLoS Medicine ◽  
2016 ◽  
Vol 13 (11) ◽  
pp. e1002164 ◽  
Author(s):  
Goodarz Danaei ◽  
Kathryn G. Andrews ◽  
Christopher R. Sudfeld ◽  
Günther Fink ◽  
Dana Charles McCoy ◽  
...  

2016 ◽  
Vol 34 (1-2) ◽  
pp. 35-42 ◽  
Author(s):  
Rupert W. Leong ◽  
Nikola Mitrev ◽  
Yanna Ko

Background: The hygiene hypothesis refers to where modern living conditions are responsible for the increasing incidences of immune-related diseases including the development of inflammatory bowel diseases (IBD). Improved hygiene may result in decreased enteric microbiota diversity and dysbiosis, which may be responsible for the development of IBD. Key Messages: The rising incidence of IBD is well documented in developing regions of the world, in accordance with the hygiene hypothesis. What is unknown, however, is whether the hygiene hypothesis is applicable all over the world. Hygiene cannot be easily measured and proxy markers need to be used. These include regional data such as a country's gross domestic product or an individual's affluence or exposure to infection risk factors. A comparative case-control study of Caucasian Australian IBD subjects versus migrants from the Middle East to Australia identified that environmental risk factors are different in the 2 populations. Among Australian Caucasians, hygiene-related environmental risk factors are no longer relevant in the development of IBD. Given the country's high affluence, there has been high hygienic standard for several generations. However, migrants from less affluent countries exposed to hygiene-related environmental factors are at increased risks of developing IBD, especially in the second generation migrants born in the affluent country. Divergent risk factors include the use of antibiotics in childhood increasing the risk of IBD in developed societies but being a risk factor for developing IBD in migrants. In India, risk factors associated with infections were found to be positively associated with the development of ulcerative colitis, rather than protective. Conclusions: The hygiene hypothesis is not applicable to all populations worldwide, being most relevant in societies undergoing increasing affluence or following migration from less to more affluent countries. This review examines data from around the world that link the hygiene hypothesis with the development of IBD and in particular the divergent results arising from data from affluent countries versus less-affluent countries.


Sign in / Sign up

Export Citation Format

Share Document