LONG-TERM EFFECTS AND AFTER-EFFECTS OF TREATMENT OF DUODENAL ULCER WITH METIAMIDE

The Lancet ◽  
1977 ◽  
Vol 309 (8015) ◽  
pp. 765-767 ◽  
Author(s):  
J.H.B. Saunders ◽  
K.G. Wormsley
Keyword(s):  
Duodenal Ulcer ◽  
Long Term Effects ◽  
After Effects

Long-term effects of Helicobacter pylori eradication on gastric antral mucosa in duodenal ulcer patients

2000 ◽  
Vol 12 (7) ◽  
pp. 719-725 ◽  
Author(s):  
Frank Zerbib ◽  
Christine Lenk ◽  
Bassem Sawan ◽  
Rémy Cayla ◽  
Nathalie Broutet ◽  
...  
Keyword(s):  
Duodenal Ulcer ◽  
Helicobacter Pylori ◽  
Antral Mucosa ◽  
Long Term Effects ◽  
Helicobacter Pylori Eradication

The Gifted Label, Gifted Children and the Aftermath

1993 ◽  
Vol 9 (1) ◽  
pp. 33-35 ◽  
Author(s):  
Brenda Ring ◽  
Michael F. Shaughnessy
Keyword(s):  
Peer Relationships ◽  
Self Esteem ◽  
Self Concept ◽  
Educational Services ◽  
Gifted Children ◽  
Long Term Effects ◽  
After Effects ◽  
The Family ◽  
Males And Females

Gifted children are receiving more and more attention and special educational services in the school system of America today. While there is much on labeling people as “mentally retarded” little has been done on the effects of labeling children as “gifted”. This paper explores the effects of labeling children as gifted. It addresses the effects that the label places on males and females and their self-concept and self-esteem. The family too, is affected in very subtle ways. The literature regarding the labeling process and its effects are discussed. Lately, peer relationships are somewhat affected both for boys and girls. Expectations are often set, and friendships are affected. Needed research in this area will be specified. We need to know more about the process and both the immediate and long-term effects, ramifications, and repercussions of the labeling process and its after effects.

scholarly journals Longer-Run Economic Consequences of Pandemics?

2021 ◽  
pp. 1-29
Author(s):  
Òscar Jordà ◽  
Sanjay R. Singh ◽  
Alan M. Taylor
Keyword(s):  
Economic Consequences ◽  
Precautionary Savings ◽  
Limited Data ◽  
Long Term Effects ◽  
Return On Assets ◽  
Rates Of Return ◽  
Neoclassical Growth Model ◽  
After Effects ◽  
Neoclassical Growth

Abstract What are the medium- to long-term effects of pandemics? Do they differ from other economic disasters? We study major pandemics using rates of return on assets stretching back to the 14th century. Significant macroeconomic after-effects of pandemics persist for decades, with rates of return substantially depressed. The responses are in stark contrast to what happens after wars. Our findings also accord with wage and output responses, using more limited data, and are consistent with the neoclassical growth model: capital is destroyed in wars, but not in pandemics; pandemics instead may induce more labor scarcity and/or more precautionary savings.

scholarly journals Controlled trial of maintenance cimetidine treatment in healed duodenal ulcer: short and long-term effects.

Gut ◽  
1979 ◽  
Vol 20 (6) ◽  
pp. 526-530 ◽  
Author(s):  
M W Dronfield ◽  
A J Batchelor ◽  
W Larkworthy ◽  
M J Langman
Keyword(s):  
Duodenal Ulcer ◽  
Controlled Trial ◽  
Long Term Effects ◽  
Cimetidine Treatment ◽  
Short And Long Term

scholarly journals Immediate and long-term effects of transcranial direct-current stimulation in the mouse primary somatosensory cortex

2020 ◽  
Author(s):  
Carlos A. Sánchez-León ◽  
Isabel Cordones ◽  
Claudia Ammann ◽  
José M. Ausín ◽  
María A. Gómez-Climent ◽  
...  
Keyword(s):  
Somatosensory Cortex ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Immunohistochemical Analysis ◽  
Primary Somatosensory Cortex ◽  
Long Term Effects ◽  
After Effects ◽  
Long Term Changes ◽  
Cathodal Stimulation

AbstractTranscranial direct-current stimulation (tDCS) is a non-invasive brain stimulation technique consisting in the application of weak electric currents on the scalp. Although previous studies have demonstrated the clinical value of tDCS for modulating sensory, motor, and cognitive functions, there are still huge gaps in the knowledge of the underlying physiological mechanisms. To define the immediate impact as well as the after-effects of tDCS on sensory processing, we first performed electrophysiological recordings in primary somatosensory cortex (S1) of alert mice during and after administration of S1-tDCS, and followed up with immunohistochemical analysis of the stimulated brain regions. During the application of cathodal and anodal transcranial currents we observed polarity-specific bidirectional changes in the N1 component of the sensory-evoked potentials (SEPs) and associated gamma oscillations. Regarding the long-term effects observed after 20 min of tDCS, cathodal stimulation produced significant after-effects including a decreased SEP amplitude for up to 30 min, a power reduction in the 20-80 Hz range and a decrease in gamma event related synchronization (ERS). In contrast, no significant long-term changes in SEP amplitude or power analysis were observed after anodal stimulation except for a significant increase in gamma ERS after tDCS cessation. The polarity-specific differences of these long-term effects were corroborated by immunohistochemical analysis, which revealed an unbalance of GAD 65-67 immunoreactivity between the stimulated vs. non-stimulated S1 region only after cathodal tDCS. These results highlight the differences between immediate and long-term effects of tDCS, as well as the asymmetric long-term changes induced by anodal and cathodal stimulation.Significance StatementHere we provide a first glimpse at the immediate and long-term impact of tDCS on neural processing in alert animals. The obtained results highlight the complexity of tDCS-associated effects, which include both bidirectional as well as asymmetrical modulation depending on the polarity of the stimulation. This asymmetry suggests the implication of different mechanisms underlying the long-term effects induced by anodal and cathodal transcranial currents. Identifying and defining these effects and its associated mechanisms is crucial to help design effective protocols for clinical applications.

scholarly journals Is the Focal Muscle Vibration an Effective Motor Conditioning Intervention? A Systematic Review

2021 ◽  
Vol 6 (2) ◽  
pp. 39
Author(s):  
Luigi Fattorini ◽  
Angelo Rodio ◽  
Vito E. Pettorossi ◽  
Guido M. Filippi
Keyword(s):  
Mechanical Vibration ◽  
Stimulus Frequency ◽  
Muscle Spindles ◽  
Long Term Effects ◽  
Time Analysis ◽  
Muscle Belly ◽  
After Effects ◽  
Motor Conditioning ◽  
Short And Long Term

Mechanical vibration, applied to single or few muscles, can be a selective stimulus for muscle spindles, able to modify neuromuscular management, inducing short and long-term effects, are now mainly employed in clinic studies. Several studies reported as treatments with focal vibratory (FVT) can influence neuromuscular parameters also in healthy people. However, the application modalities and the consequent effects are remarkably fragmented. This paper aims to review these studies and to characterize the FVT effectiveness on long-term conditional capacities in relation to FVT characteristics. A systematic search of studies published from 1985 to 2020 in English on healthcare databases was performed. Articles had to meet the following criteria: (1) treatment based on a locally applied vibration on muscle belly or tendon; (2) healthy adults involved; (3) outcomes time analysis enduring for more than 24 h. Twelve studies were found, all of them presented an excellent quality score of ≥75%. All selected papers reported positive changes, comparable with traditional long-lasting training effects. Muscle force and power were the most investigated parameters. The after-effects persisted for up to several months. Among the different FV administration modalities, the most effective seems to show a stimulus frequency of ≈100 Hz, repeated more times within three-five days on a voluntary contracted muscle.

Ovarian Dysfunction in Fetally Irradiated Beagles

1977 ◽  
Vol 35 ◽  
pp. 658-659
Author(s):  
T. M. Seed ◽  
M. H. Sanderson ◽  
D. L. Gutzeit ◽  
T. E. Fritz ◽  
D. V. Tolle ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Low Dose ◽  
Long Term Effects ◽  
Ovarian Dysfunction ◽  
Dose Rates ◽  
Highly Sensitive ◽  
Microscopic Evaluation ◽  
Ovarian Pathology ◽  
Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

Ultrastructural investigations of MDL 19,660-induced effects on the canine platelet and megakaryocyte

1990 ◽  
Vol 48 (3) ◽  
pp. 374-375
Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson
Keyword(s):  
Antidepressant Drug ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Short Term ◽  
Platelet Counts ◽  
Toxicological Studies ◽  
Induced Aggregation ◽  
Internal Architecture

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.

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