Correlation between uric acid and body fat distribution in type 2 diabetes mellitus

Monocyte/macrophage-specific soluble CD163 (sCD163) concentration is associated with insulin resistance and increases with deteriorating glycemic control independently of BMI. This led to the proposal of the hypothesis that obesity-associated white adipose tissue inflammation varies between individuals. The objective was to examine the effect of male overweight/obesity and type 2 diabetes mellitus (T2DM) on associations between adiposity parameters and sCD163. A total of 23 overweight/obese non-diabetic men, 16 overweight/obese men with T2DM, and a control group of 20 normal-weight healthy men were included. Body composition and regional body fat distribution were determined by whole-body dual X-ray absorptiometry scan and abdominal computed tomography (CT) scan. Serum sCD163 concentrations were determined by ELISA. Associations between adiposity parameters and sCD163 were investigated using multiple linear regression analysis. In the normal-weight healthy men, there was no significant association between adiposity parameters and sCD163, whereas in the overweight/obese non-diabetic men, measures of general and regional adiposity were positively associated with sCD163. In the overweight/obese men with T2DM, only visceral adipose tissue (VAT) and the ratio of VAT to abdominal subcutaneous adipose tissue (SAT), a measure of relative body fat distribution between VAT and SAT depots, were positively associated with sCD163. In a multivariate analysis, including VAT, upper-body SAT, and lower-body fat, adjusted for BMI and age, VAT remained a significant predictor of sCD163 in the overweight/obese T2DM men, but not in the overweight/obese non-diabetic men. Our results indicate that VAT inflammation is exaggerated in men with T2DM, and that propensity to store excess body fat viscerally is particularly detrimental in men with T2DM.

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Body fat distribution, cardiorespiratory fitness, and lipid profile in first degree relatives with type 2 diabetes mellitus

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v10i4.1637 ◽

2019 ◽

Vol 10 (4) ◽

pp. 3293-3296

Author(s):

Shaik Azmatulla ◽

Rinku Garg ◽

Anil Kumar Sharma ◽

Navpret Mann

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Lipid Profile ◽

Cardiorespiratory Fitness ◽

Body Fat ◽

Fat Distribution ◽

Low Density Lipoproteins ◽

Low Density

Evaluation of people at increased risk like first degree relatives of type 2 diabetes mellitus (FDRDM) may be useful to reduce the risk of disease progression, development, early intervention, and to take precautionary measures. By considering the multifactorial pathophysiological changes of D.M., we have examined the body fat distribution, cardiorespiratory fitness, and lipid profile of FDRDM. Similar age, height, waist-hip ratio (WHR) in both groups, significantly higher body mass index (BMI) in FDRDM, was observed in our study. Percentage body fat and blood glucose levels in fasting were elevated considerably, and 12 min walk distance was low in FDRDM. Visceral fat was slightly high, but it was not statistically significant. In FDRDM, High-density lipoproteins (HDL) were less but not statistically significant. Significantly higher levels of Total cholesterol (T.C.), triglycerides (TGL), low-density lipoproteins (LDL), and very-low-density lipoproteins (VLDL) were seen high in FDRDM when compared to controls. Higher body fat percentage reduced cardiorespiratory function and abnormal lipid profile in FDRDM may lead to the development of severe cardiovascular events and necessitates lifestyle modification at early phases of disease development.

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Body Fat, Fat Distribution, and Psychosocial Factors Among Patients With Type 2 Diabetes Mellitus

Behavioral Medicine ◽

10.1080/08964289809596392 ◽

1998 ◽

Vol 24 (3) ◽

pp. 138-143 ◽

Cited By ~ 7

Author(s):

Ronny A. Bell ◽

John H. Summerson ◽

Joseph C. Konen

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Psychosocial Factors ◽

Body Fat ◽

Fat Distribution

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Rheumatoid Factor in Type 2 Male Diabetes Mellitus Patients in a Tertiary Care Hospital of Bangladesh

Journal of Current and Advance Medical Research ◽

10.3329/jcamr.v4i2.36358 ◽

2018 ◽

Vol 4 (2) ◽

pp. 58-62

Author(s):

Roksana Yeasmin ◽

MA Muttalib ◽

Kazi Nazneen Sultana ◽

Nizamul Hoque Bhuiyan ◽

Md Jamil Hasan Karami ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Uric Acid ◽

Rheumatoid Factor ◽

Serum Uric Acid ◽

Control Group ◽

Healthy Male ◽

Male Patients

Background: Type 2 diabetes mellitus is a chronic disease characterized by relative or absolute deficiency of insulin, resulting in glucose intolerance.Objectives: The present study was planned to see the associations of serum uric acid with positive Rheumatoid factor in type 2 male diabetes mellitus patients. Methodology: This case control study was carried out at the department of Biochemistry at Ibrahim Medical College, Dhaka, Bangladesh. The duration of the study was from June 2015 to June 2016 for a period of one year. In this present study, male patients with type 2 diabetes mellitus were taken as case group and age and sex matched healthy male were taken as control group. Rheumatoid factor was measured from the blood of all case and control group respondents. Others blood para meters were also measured for the correlation with the diabetes mellitus patients.Results: In this present study, 110 male patients presented with type 2 diabetes mellitus were recruited as case and age and sex matched healthy male were recruited as control. More rheumatoid factor positive in type 2 DM male patients with the uric acid range between 6.5 to 9.5 mg/dL. The number of patients was 5 out of total 9 rheumatoid factor positive cases. In this study serum uric acid was significantly correlated with rheumatoid factor in type 2 male diabetic patients. Rheumatoid factor positive cases were taking insulin among 9 and it was statistically significantly associated (p<0.001). Conclusion: In this study serum uric acid is significantly associated with positive rheumatoid factor in type 2 male diabetic patients.Journal of Current and Advance Medical Research 2017;4(2):58-62

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