Protective effects of FUT-175 on acute massive hepatic necrosis induced in mice following endotoxin injection and immunization with liver proteins

This study is an attempt to evaluate the hepatoprotective activity ofTabernaemontana divaricataagainst DEN and Fe NTA induced liver necrosis in rats. Ethanolic extract of the whole plant ofTabernaemontana divaricataat doses of 200 and 400 mg/kg body weight and 5-fluorouracil (standard drug) was orally administered to male Wistar Albino rats once daily for 24 weeks, simultaneously treated with the carcinogen DEN and Fe NTA. In simultaneously treated animals, the plant extract significantly decreased the levels of uric acid, bilirubin, AST, ALT, and ALP in serum and increased the levels of liver marker enzymes in liver. Treatment with the extracts resulted in a significant increase in the levels of antioxidants accompanied by a marked reduction in the levels of malondialdehyde when compared to DEN and Fe NTA treated group. When compared with 200 mg/kg bw rats, 400 mg/kg bw rats and 5-fluorouracil treated rats showed better results in all the parameters. The histopathological studies confirmed the protective effects of extract against DEN and Fe NTA induced liver necrosis. Thus, it could be concluded that the use ofTabernaemontana divaricataextract in the treatment of carcinogen induced hepatic necrosis.

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Regional Radioactivity Discrepancy Between Tc-99m GSA and Tc-99m Phytate Liver Scans in a Patient with Massive Hepatic Necrosis

Clinical Nuclear Medicine ◽

10.1097/00003072-200208000-00008 ◽

2002 ◽

Vol 27 (8) ◽

pp. 584-588

Author(s):

SHIRO AKAKI ◽

MOTOTSUGU SAEKI ◽

TOSHIHIRO IGUCHI ◽

YOSHIHIRO OKUMURA ◽

SHUHEI SATO ◽

...

Keyword(s):

Hepatic Necrosis ◽

Massive Hepatic Necrosis

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Acute Fulminant Hepatic Failure in a Woman Treated With Phenytoin and Trimethoprim-Sulfamethoxazole

Archives of Pathology & Laboratory Medicine ◽

10.5858/2000-124-1800-afhfia ◽

2000 ◽

Vol 124 (12) ◽

pp. 1800-1803 ◽

Cited By ~ 1

Author(s):

Marius J-M. Ilario ◽

Jose E. Ruiz ◽

Constantine A. Axiotis

Keyword(s):

Liver Injury ◽

Liver Failure ◽

Acute Liver Failure ◽

Fulminant Hepatic Failure ◽

Hepatic Failure ◽

Acute Hepatic Failure ◽

Hepatic Necrosis ◽

Rare Occurrence ◽

Autopsy Findings ◽

Massive Hepatic Necrosis

Abstract Massive hepatic necrosis following exposure to phenytoin and trimethoprim-sulfamethoxazole is a rare occurrence and to the best of our knowledge has not been reported previously. Acute hepatic failure following administration of trimethoprim-sulfamethoxazole has rarely been seen, and only 4 cases have been well documented pathologically. We report a case of acute liver failure in a 60-year-old woman following ingestion of phenytoin and trimethoprim-sulfamethoxazole concomitantly over a 9-day period. Autopsy findings revealed acute fulminant hepatic failure. This case demonstrates the effects of chemical-chemical interactions in the potentiation of hepatotoxicity of single agents and specifically illustrates the need for discontinuing trimethoprim-sulfamethoxazole in the presence of early liver injury.

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Fucosterol Protects against Concanavalin A-Induced Acute Liver Injury: Focus on P38 MAPK/NF-κB Pathway Activity

Gastroenterology Research and Practice ◽

10.1155/2018/2824139 ◽

2018 ◽

Vol 2018 ◽

pp. 1-13 ◽

Cited By ~ 10

Author(s):

Wenhui Mo ◽

Chengfen Wang ◽

Jingjing Li ◽

Kan Chen ◽

Yujing Xia ◽

...

Keyword(s):

Liver Injury ◽

P38 Mapk ◽

Concanavalin A ◽

Molecular Mechanisms ◽

Therapeutic Agent ◽

Acute Liver Injury ◽

Biological Activities ◽

Hepatic Necrosis ◽

Protective Effects ◽

Eisenia Bicyclis

Objective. Fucosterol is derived from the brown alga Eisenia bicyclis and has various biological activities, including antioxidant, anticancer, and antidiabetic properties. The aim of this study was to investigate the protective effects of fucosterol pretreatment on Concanavalin A- (ConA-) induced acute liver injury in mice, and to understand its molecular mechanisms. Materials and Methods. Acute liver injury was induced in BALB/c mice by ConA (25 mg/kg), and fucosterol (dissolved in 2% DMSO) was orally administered daily at doses of 25, 50, and 100 mg/kg. The levels of hepatic necrosis, apoptosis, and autophagy associated with inflammatory cytokines were measured at 2, 8, and 24 h. Results. Fucosterol attenuated serum liver enzyme levels and hepatic necrosis and apoptosis induced by TNF-α, IL-6, and IL-1β. Fucosterol also inhibited apoptosis and autophagy by upregulating Bcl-2, which decreased levels of functional Bax and Beclin-1. Furthermore, reduced P38 MAPK and NF-κB signaling were accompanied by PPARγ activation. Conclusion. This study showed that fucosterol could alleviate acute liver injury induced by ConA by inhibiting P38 MAPK/PPARγ/NF-κB signaling. These findings highlight that fucosterol is a promising potential therapeutic agent for acute liver injury.

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MASSIVE HEPATIC NECROSIS

Anesthesiology ◽

10.1097/00000542-196905000-00007 ◽

1969 ◽

Vol 30 (5) ◽

pp. 505-505

Keyword(s):

Hepatic Necrosis ◽

Massive Hepatic Necrosis

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Massive hepatic necrosis with large regenerative nodules

The Korean Journal of Hepatology ◽

10.3350/kjhep.2010.16.3.334 ◽

2010 ◽

Vol 16 (3) ◽

pp. 334 ◽

Cited By ~ 3

Author(s):

Haeryoung Kim ◽

Young Nyun Park

Keyword(s):

Hepatic Necrosis ◽

Massive Hepatic Necrosis ◽

Regenerative Nodules

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Hepatotoxicity of Two Progoitrin-Derived Nitriles in New Zealand White Rabbits

Toxins ◽

10.3390/toxins12110695 ◽

2020 ◽

Vol 12 (11) ◽

pp. 695

Author(s):

Mark Grey Collett ◽

Zoe Maree Matthews ◽

Kathleen Henry Parton

Keyword(s):

New Zealand ◽

Pilot Trial ◽

Elevated Serum ◽

Hepatic Necrosis ◽

Severe Illness ◽

Forage Crops ◽

Brassica Spp ◽

Massive Hepatic Necrosis ◽

New Zealand White Rabbits ◽

Higher Doses

Cattle occasionally develop brassica-associated liver disease (BALD) and photosensitisation when grazing turnip or swede (Brassica spp.) forage crops. The liver toxin in these brassica varieties has yet to be discovered. Progoitrin is the dominant glucosinolate in incriminated crops. Apart from goitrin, progoitrin hydrolysis yields the nitrile, 1-cyano-2-hydroxy-3-butene (CHB), and the epithionitrile, 1-cyano-2-hydroxy-3,4-epithiobutane (CHEB). The two compounds were custom-synthesised. In a small pilot trial, New Zealand White rabbits were given either CHB or CHEB by gavage. Single doses of 0.75 mmol/kg of CHB or 0.25 mmol/kg of CHEB were subtoxic and elicited subclinical effects. Higher doses were severely hepatotoxic, causing periportal to massive hepatic necrosis associated with markedly elevated serum liver biomarkers often resulting in severe illness or death within 24 h. The possibility that one or both of these hepatotoxic nitriles causes BALD in cattle requires further investigation.

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