337 INVESTIGATING THE TISSUE TURNOVER PROFILE IN LIVER FIBROSIS BY NOVEL BIOCHEMICAL MARKERS OF EXTRACELLULAR MATRIX REMODELING

2011 ◽  
Vol 54 ◽  
pp. S135
Author(s):  
D.J. Leeming ◽  
S.S. Veidal ◽  
E. Vassiliadis ◽  
N. Barascuk ◽  
Y. He ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Liver Fibrosis ◽  
Biochemical Markers ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Tissue Turnover

Extracellular Matrix Remodeling with Focus on Biochemical Markers in Liver Fibrosis: Limitations and Possibilities

2018 ◽  
pp. 265-286
Author(s):  
Mette Juul Nielsen ◽  
Morten A. Karsdal ◽  
Aleksander Krag ◽  
Diana Julie Leeming
Keyword(s):  
Extracellular Matrix ◽  
Liver Fibrosis ◽  
Biochemical Markers ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling

1058 THE REMODELING PROFILE OF STRUCTURAL PROTEINS INVOLVED LIVER FIBROSIS - EVALUATION OF NINE NOVEL BIOCHEMICAL MARKERS OF EXTRACELLULAR MATRIX REMODELING

2012 ◽  
Vol 56 ◽  
pp. S414-S415
Author(s):  
D.J. Leeming ◽  
E. Vassiliadis ◽  
I. Byrjalsen ◽  
M.J. Nielsen ◽  
S.S. Veidal ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Liver Fibrosis ◽  
Biochemical Markers ◽  
Structural Proteins ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling

WISP1: A novel extracellular matrix remodeling protein in liver fibrosis

2020 ◽  
Author(s):  
D González ◽  
R Katharina ◽  
JG Hengstler
Keyword(s):  
Extracellular Matrix ◽  
Liver Fibrosis ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling

scholarly journals Dose-Dependent Antifibrotic Effect of Chrysin on Regression of Liver Fibrosis: The Role in Extracellular Matrix Remodeling

Dose-Response ◽  
2018 ◽  
Vol 16 (3) ◽  
pp. 155932581878983 ◽  
Author(s):  
Cornel Balta ◽  
Alina Ciceu ◽  
Hildegard Herman ◽  
Marcel Rosu ◽  
Oana Maria Boldura ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Liver Fibrosis ◽  
Mouse Liver ◽  
Ultrastructural Changes ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Tissue Inhibitors Of Metalloproteinase ◽  
Spontaneous Reversion ◽  
New Strategy ◽  
Dose Dependent

Liver fibrosis represents an overaccumulation of extracellular matrix (ECM). This study was designed to investigate the effect of chrysin on established ECM overproduction in carbon tetrachloride (CCl4) mouse liver fibrosis. Experimental fibrosis was induced by intraperitoneal injection of 2 mL/kg CCl4 twice a week, for 7 weeks. Mice were orally treated with 3 doses of chrysin (5,7-dihydroxyflavone). For the assessment of the spontaneous reversion of fibrosis, CCl4-treated mice were investigated after 2 weeks of recovery time. Silymarin was used as a standard of liver protection. In fibrotic livers, the results showed the upregulation of collagen I (Col I) and tissue inhibitors of metalloproteinase 1 (TIMP-1) and modulation of matrix metalloproteinases (MMPs), which led to an altered ECM enriched in Col, confirmed as well by electron microscopy investigations. Treatment with chrysin significantly reduced ultrastructural changes, downregulated Col I, and restored TIMP-1/MMP balance, whereas in the group observed for the spontaneous regression of fibrosis, they remained in the same pattern with fibrotic livers. In this study, we have shown chrysin efficacy to attenuate dose-dependent CCl4-stimulated liver ECM accumulation by regulation of MMP/TIMP imbalance and inhibition of Col production. We have shown the dose-dependent chrysin efficiency in attenuation of CCl4-induced liver ECM accumulation by regulation of MMP/TIMP imbalance and inhibition of Col production. Our findings suggest that chrysin oral administration may introduce a new strategy for treating liver fibrosis in humans.

scholarly journals The Dynamic Interaction between Extracellular Matrix Remodeling and Breast Tumor Progression

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1046
Author(s):  
Jorge Martinez ◽  
Patricio C. Smith
Keyword(s):  
Extracellular Matrix ◽  
Type I Collagen ◽  
Cell Metabolism ◽  
Breast Tumors ◽  
Extracellular Matrix Remodeling ◽  
Type I ◽  
Matrix Remodeling ◽  
Desmoplastic Reaction ◽  
The Impact

Desmoplastic tumors correspond to a unique tissue structure characterized by the abnormal deposition of extracellular matrix. Breast tumors are a typical example of this type of lesion, a property that allows its palpation and early detection. Fibrillar type I collagen is a major component of tumor desmoplasia and its accumulation is causally linked to tumor cell survival and metastasis. For many years, the desmoplastic phenomenon was considered to be a reaction and response of the host tissue against tumor cells and, accordingly, designated as “desmoplastic reaction”. This notion has been challenged in the last decades when desmoplastic tissue was detected in breast tissue in the absence of tumor. This finding suggests that desmoplasia is a preexisting condition that stimulates the development of a malignant phenotype. With this perspective, in the present review, we analyze the role of extracellular matrix remodeling in the development of the desmoplastic response. Importantly, during the discussion, we also analyze the impact of obesity and cell metabolism as critical drivers of tissue remodeling during the development of desmoplasia. New knowledge derived from the dynamic remodeling of the extracellular matrix may lead to novel targets of interest for early diagnosis or therapy in the context of breast tumors.

Extracellular Matrix Remodeling in Idiopathic Pulmonary Fibrosis

CHEST Journal ◽  
2001 ◽  
Vol 120 (1) ◽  
pp. S77 ◽  
Author(s):  
Annie Pardo ◽  
Moisés Selman
Keyword(s):  
Extracellular Matrix ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling

scholarly journals Aryl Hydrocarbon Receptor Activation Impairs Extracellular Matrix Remodeling during Zebra Fish fin Regeneration

2006 ◽  
Vol 95 (1) ◽  
pp. 215-226 ◽  
Author(s):  
Eric A. Andreasen ◽  
Lijoy K. Mathew ◽  
Christiane V. Löhr ◽  
Rachelle Hasson ◽  
Robert L. Tanguay
Keyword(s):  
Extracellular Matrix ◽  
Aryl Hydrocarbon Receptor ◽  
Receptor Activation ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Zebra Fish ◽  
Fin Regeneration ◽  
Aryl Hydrocarbon

Umbilical artery extracellular matrix remodeling in fetal growth restriction

2004 ◽  
Vol 191 (6) ◽  
pp. S10
Author(s):  
Wendy Kinzler ◽  
John Smulian ◽  
C. Andrew Kistler ◽  
Rita Hahn ◽  
Peihong Zhou ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Umbilical Artery ◽  
Growth Restriction ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling
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