Urinary excretion of pyridinolines crosslinks measured by immunoassay and HPLC techniques in normal subjects and in elderly patients with vitamin D deficiency

1. The response to exogenous parathyroid hormone (PTH) was tested in normal subjects and patients with osteomalacia due to vitamin D deficiency; 200 MRC units of bovine PTH were administered intravenously. 2. The rise in plasma adenosine 3′:5′-cyclic monophosphate (cyclic AMP) and the increase in urinary excretion of cyclic AMP were reduced in the patients with vitamin D deficiency. After treatment with vitamin D the responses returned to normal. 3. It is suggested that this reversible resistance is due to the secondary hyperparathyroidism associated with vitamin D deficiency.

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Urinary Excretion of Adenosine 3'5‘ Monophosphate in Vitamin D Deficiency

European Journal of Clinical Investigation ◽

10.1111/j.1365-2362.1976.tb00502.x ◽

1976 ◽

Vol 6 (1) ◽

pp. 127-130 ◽

Cited By ~ 3

Author(s):

M. Vainsel ◽

Th. Manderlier ◽

J. Otten

Keyword(s):

Vitamin D ◽

Urinary Excretion ◽

Vitamin D Deficiency

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High prevalence of vitamin D deficiency in elderly patients with advanced osteoarthritis scheduled for total knee replacement associated with poorer preoperative functional state

Annals of The Royal College of Surgeons of England ◽

10.1308/rcsann.2013.95.8.569 ◽

2013 ◽

Vol 95 (8) ◽

pp. 569-572 ◽

Cited By ~ 25

Author(s):

JA Jansen ◽

FS Haddad

Keyword(s):

Vitamin D ◽

Total Knee Replacement ◽

Elderly Patients ◽

Knee Osteoarthritis ◽

Vitamin D Deficiency ◽

Knee Replacement ◽

Functional State ◽

High Prevalence ◽

Outcome Scores ◽

Total Knee

Vitamin D deficiency has been reported previously in patients with osteoarthritis undergoing total hip arthroplasty. We found a high prevalence of vitamin D deficiency in elderly patients with advanced knee osteoarthritis scheduled for total knee replacement and also a significant association with a lower preoperative functional state. A review of the literature is given on vitamin D deficiency in patients with knee osteoarthritis and the association with lower outcome scores after arthroplasty is discussed.

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URINARY EXCRETION OF ADENOSINE 3'5' MONOPHOSPHATE IN VITAMIN D DEFICIENCY

Pediatric Research ◽

10.1203/00006450-197511000-00030 ◽

1975 ◽

Vol 9 (11) ◽

pp. 857-857

Author(s):

M Vainsel ◽

Th Manderlier ◽

J Otten

Keyword(s):

Vitamin D ◽

Urinary Excretion ◽

Vitamin D Deficiency

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Phosphorus adaptation in rats in absence of vitamin D or parathyroid glands

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.1980.239.4.g261 ◽

1980 ◽

Vol 239 (4) ◽

pp. G261-G265

Author(s):

C. F. Cramer ◽

J. McMillan

Keyword(s):

Vitamin D ◽

Urinary Excretion ◽

Vitamin D Deficiency ◽

Intestinal Absorption ◽

Control Diet ◽

Inorganic Phosphorus ◽

Parathyroid Glands ◽

Intestinal Excretion ◽

Growing Rats ◽

Pi Deficiency

Growing rats even when vitamin D deficient became adapted to inorganic phosphorus (Pi) deficiency by increasing absorption and minimizing excretion. Feeding low-Pi diet for 3 wk reduced urinary Pi by 80% (P < 0.001), and urinary 32P by 50% (P < 0.001). Low-Pi regimen increased 32p absorption from a 32P-labeled meal by 50% (P < 0.001), even when the animals were vitamin D deficient or thyroparathyroidectomized. The marked increase in retention of 32P in phosphorus-deficient rats could not be accounted for by decreased endogenous intestinal excretion plus increased kidney reabsorption; increased intestinal absorption played a part. 32P absorption was significantly reduced (P < 0.001) by vitamin D deficiency in rats fed either control diet (.6%) Pi or low-Pi diet (0.03%). Endogenous intestinal or urinary excretion of 32P was unaltered by vitamin D deficiency. The evidence supports the hypothesis that there are two mechanisms for phosphorus adaptation: kidney retention not requiring vitamin D, and inreased intestinal absorption of Pi not requiring parathyroids, thyroids, or vitamin D.

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Does vitamin D deficiency increase orthostatic hypotension risk in the elderly patients?

Archives of Gerontology and Geriatrics ◽

10.1016/j.archger.2014.03.008 ◽

2014 ◽

Vol 59 (1) ◽

pp. 74-77 ◽

Cited By ~ 27

Author(s):

Pinar Soysal ◽

Adnan Yay ◽

Ahmet Turan Isik

Keyword(s):

Vitamin D ◽

Elderly Patients ◽

Orthostatic Hypotension ◽

Vitamin D Deficiency ◽

The Elderly

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Association of 25-OH vitamin D deficiency with worse outcome for elderly patients with aggressive B-cell lymphomas treated with CHOP plus rituximab (R): An analysis of the RICOVER-60 trial of the German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL).

Journal of Clinical Oncology ◽

10.1200/jco.2013.31.15_suppl.8569 ◽

2013 ◽

Vol 31 (15_suppl) ◽

pp. 8569-8569

Author(s):

Joerg Thomas Bittenbring ◽

Marina Achenbach ◽

Bettina Altmann ◽

Marita Ziepert ◽

Joerg Reichrath ◽

...

Keyword(s):

Vitamin D ◽

Elderly Patients ◽

B Cell ◽

Vitamin D Deficiency ◽

Prospective Trial ◽

Multivariable Analysis ◽

Serum Levels ◽

B Cell Lymphomas ◽

Vitamin D Levels ◽

25 Oh Vitamin D

8569 Background: Vitamin D deficiency was shown to be is associated with a worse outcome in patients with non-Hodgkin's lymphoma (Drake et al., 2010) To study whether this observation could be confirmed in patients with aggressive B-cell lymphomas treated uniformly within a prospective trial, we analyzed 25-OH vitamin D serum levels in patients treated within the RICOVER-60 trial of the DSHNHL. Methods: 25-OH Vitamin D serum levels were determined with a commercial chemoluminescence immunoassay in the serum from elderly patients of the RICOVER-60 trial which compared 6 or 8 cycles of CHOP, both with and without rituximab. Results: 193 of 359 pts (53.8%) had vitamin D deficiency (<10 ng/ml) and 165/359 patients (46.0%) had vitamin D insufficiency (10-30 ng/ml) according to current definitions. When treated with R-CHOP, patients with vitamin D levels ≤8 ng/ml had a 3-year EFS of 59% compared to 79% of patients with vitamin D serum levels >8 ng/ml; the respective figures for 3-year overall survival were 70% and 82%, respectively. In R-CHOP pts these differences were significant in a multivariable analysis adjusting for IPI risk factors with a hazard ratio (HR) of 2.1 (p=0.008) for EFS and a HR of 1.9 (p=0.040) for OS. In pts treated without R effects of vitamin D deficiency were significant only for OS (HR 1.8; p=0.025), but not with respect to EFS (HR 1.2; p=0.388). These results were confirmed in an independent validation set of 63 patients treated within the prospective RICOVER-noRx study. Conclusions: Vitamin D deficiency is a significant risk factor for patients with aggressive B-cell lymphomas treated with R-CHOP. The stronger adverse effect of vitamin D deficiency in patients receiving rituximab suggests that vitamin D deficiency interferes with the R mechanisms of this antibody. A prospective study evaluating the effects of vitamin D substitution on outcome of patients receiving R-CHOP is warranted. Supported by Deutsche Krebshilfe.

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PREVALENCE OF VITAMIN DEFICIENCY IN ELDERLY PATIENTS PLANNED FOR SPINE SURGERY

Успехи геронтологии ◽

10.34922/ae.2020.33.6.024 ◽

2021 ◽

pp. 1193-1199

Author(s):

И. А. Степанов ◽

В. А. Белобородов ◽

М. А. Шамеева ◽

И. И. Томашов ◽

З. С. Саакян ◽

...

Keyword(s):

Vitamin D ◽

Elderly Patients ◽

Vitamin D Deficiency ◽

Surgical Procedures ◽

Active Form ◽

Binary Logistic Regression ◽

Mineral Density ◽

Binary Logistic Regression Model ◽

Surgical Interventions

Снижение минеральной плотности костной ткани выступает наиболее частной причиной формирования осложнений в отдаленном периоде послеоперационного наблюдения. Цель исследования - изучить распространенность дефицита витамина D у пациентов пожилого возраста, планируемых к выполнению оперативных вмешательств на позвоночнике. В исследование включены 63 пациента пожилого возраста, госпитализированных в спинальные хирургические клиники для планового оперативного вмешательства по поводу дегенеративных заболеваний шейного и пояснично-крестцового отделов позвоночника (34 женщины, 29 мужчин, средний возраст - 63,6±3,2 года). Построение модели бинарной логистической регрессии показало, что достоверно ассоциированы с наличием дефицита активной формы витамина D у пациентов, планируемых к выполнению оперативных вмешательств на позвоночнике, следующие параметры: мужской пол, возраст (старше 65 лет), ИМТ (>30 кг/м) и сахарный диабет. Определение факторов риска, ассоциированных с наличием дефицита витамина D , и исследование маркеров костного метаболизма представляют собой важнейший этап предоперационной подготовки пациентов старшей возрастной группы, планируемых к выполнению оперативных вмешательств на позвоночнике. A decrease in bone mineral density is the most common cause of complications in the long-term period of postoperative observation. The purpose of the study was to study the prevalence of vitamin D deﬁciency in elderly patients who are planning to perform spine surgical procedures. The study included 63 elderly patients hospitalized in spine surgical clinics in order to perform planned surgical procedures for degenerative diseases of the cervical and lumbar spine (34 women, 29 men, average age 63,6±3,2 years). The construction of a binary logistic regression model showed that the following parameters are reliably associated with a deﬁciency of the active form of vitamin D in patients who are planning to perform surgical interventions on the spine: male gender, age (over 65 years), body mass index (more than 30 kg/ m) and diabetes. The identiﬁcation of risk factors associated with the presence of vitamin D deﬁciency and the study of markers of bone metabolism represent the most important stage in the preoperative preparation of older patients who are planning to perform surgical interventions on the spine.

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