P2355 The close relationship between post-prandial remnant metabolism and insulin resistance

The close relationship between increased TLR-2 expression in blood monocytes and insulin resistance in RA patients is shown in this study. Traditional risk factors for metabolic disorders, including the waist circumstance, body mass index (BMI), triglyceride (TG), and ratio of TG to high density lipoprotein (HDL) cholesterol, were closely correlated with HOMA (homoeostasis model assessment) index in patients with nondiabetic RA. Expressions of TLR2 in peripheral blood monocytes, following stimulation with peptidoglycan which is known as a TLR2 agonist, were closely correlated with the HOMA index, TNF-α, and IL-6 concentrations. Accordingly, TLR-2 receptor and its related inflammatory cytokines could be potential therapeutic targets in managing insulin resistance in RA patients.

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The close relationship between postprandial remnant metabolism and insulin resistance

Atherosclerosis ◽

10.1016/j.atherosclerosis.2003.09.016 ◽

2004 ◽

Vol 172 (1) ◽

pp. 151-154 ◽

Cited By ~ 23

Author(s):

Jun-ichi Funada ◽

Michihito Sekiya ◽

Takashi Otani ◽

Kouki Watanabe ◽

Makoto Sato ◽

...

Keyword(s):

Insulin Resistance ◽

Close Relationship

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Adiponectin and osteocalcin: relation to insulin sensitivity

Biochemistry and Cell Biology ◽

10.1139/o2012-022 ◽

2012 ◽

Vol 90 (5) ◽

pp. 613-620 ◽

Cited By ~ 15

Author(s):

Yanjun Zhang ◽

Peng Zhou ◽

Julia Wanjiru Kimondo

Keyword(s):

Insulin Resistance ◽

The Body ◽

Whole Body ◽

Mineral Density ◽

Animal Physiology ◽

Proliferation And Differentiation ◽

Close Relationship ◽

Health Quality ◽

Health Quality Of Life

Obesity and osteoporosis have grave consequences for human health, quality of life, and even the efficiency of the labor force. Interestingly, these diseases share several features including a genetic predisposition and a common progenitor cell. Recent findings show that high adipocyte count in bone marrow is directly related to bone loss, as fat cells replace osteoblasts resulting in reduced bone mineral density and increased propensity towards osteoporosis. This close relationship has a positive aspect, whereby higher osteocalcin levels results in increased adiponectin production while the presence of adiponectin influences osteoblast proliferation and differentiation in a positive way. We focus on how osteoblasts and adipocytes affect each other and ultimately insulin resistance through the hormones they produce. This approach to whole animal physiology is the main stay of Alternative Medicine. It is assumed that the body is linked together intricately, and treating one is equal to treating the whole body. As we go further into bone and adipocytes physiology, it is evident that these organs affect each other. Therefore, elucidation on the actions of fat on bone and vice versa will unravel the complex mechanism of insulin resistance.

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Transcriptional Analysis of FOXO1, C/EBP- and PPAR-2 Genes and Their association with Obesity-Related Insulin Resistance

Genes ◽

10.3390/genes10090706 ◽

2019 ◽

Vol 10 (9) ◽

pp. 706 ◽

Cited By ~ 6

Author(s):

Boughanem ◽

Cabrera-Mulero ◽

Millán-Gómez ◽

Garrido-Sánchez ◽

Cardona ◽

...

Keyword(s):

Insulin Resistance ◽

Expression Profile ◽

Promoter Sequence ◽

Transcriptional Analysis ◽

Morbidly Obese ◽

Enhancer Binding Protein ◽

Close Relationship ◽

High Insulin ◽

Weak Activity ◽

Visceral Adipose

Background: Obesity is associated with several comorbid disorders, ranging from cardiovascular diseases to insulin resistance. In this context, visceral adipose tissue (VAT) seems to have a close connection with insulin resistance. In our study, we hypothesized that the expression profile of key adipogenic genes, such as proliferator-activated receptor γ type 2 (PPAR-γ2), CCAAT/enhancer-binding protein type α (C/EBP-α), and forkhead box protein class O type 1 (FOXO1) in VAT should shed light on their association with obesity-related insulin resistance. Methods: To test this idea, we studied the expression profile of C/EBP-α, FOXO1 and PPAR-γ2 in VAT from non-obese individuals, and low insulin (LIR-MO) and high insulin morbidly obese (HIR-MO) subjects, through a combination of RT-qPCR, co-immunoprecipitation, ELISA, Western blot analysis and EMSA assays. Results: Our results show that C/EBP-α and PPAR-γ2 were down-expressed in HIR-MO individuals, while FOXO1 was overexpressed. In addition, the PPAR-γ2–RXR-α heterodimer showed weak activity and bound weakly to the putative IGFBP-2–PPRE promoter sequence in VAT from HIR-MO subjects when compared with LIR-MO individuals. Conclusions: These results show that PPAR-γ2, C/EBP-α, FOXO1 and IGFBP-2 have a close relationship with insulin resistance in VAT of morbidly obese individuals.

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