Adiponectin and osteocalcin: relation to insulin sensitivity

2012 ◽  
Vol 90 (5) ◽  
pp. 613-620 ◽  
Author(s):  
Yanjun Zhang ◽  
Peng Zhou ◽  
Julia Wanjiru Kimondo

Obesity and osteoporosis have grave consequences for human health, quality of life, and even the efficiency of the labor force. Interestingly, these diseases share several features including a genetic predisposition and a common progenitor cell. Recent findings show that high adipocyte count in bone marrow is directly related to bone loss, as fat cells replace osteoblasts resulting in reduced bone mineral density and increased propensity towards osteoporosis. This close relationship has a positive aspect, whereby higher osteocalcin levels results in increased adiponectin production while the presence of adiponectin influences osteoblast proliferation and differentiation in a positive way. We focus on how osteoblasts and adipocytes affect each other and ultimately insulin resistance through the hormones they produce. This approach to whole animal physiology is the main stay of Alternative Medicine. It is assumed that the body is linked together intricately, and treating one is equal to treating the whole body. As we go further into bone and adipocytes physiology, it is evident that these organs affect each other. Therefore, elucidation on the actions of fat on bone and vice versa will unravel the complex mechanism of insulin resistance.

Author(s):  
Iraci Gonçalves Guimarães ◽  
Maria Helena Silva Carneiro

Se perguntarmos as pessoas a nossa volta o que se opõe a vida, provavelmente a larga maioria responderá que é a morte. Este dualismo, conflituoso, doloroso, cheio de contradição nos impede, por exemplo, de ver a morte como um processo natural, como algo que faz parte da vida. A velhice, por sua vez, é associada, de modo geral, às modificações no corpo pois, com a idade, o organismo sofre um desgaste natural. Os sinais externos e, portanto, mais aparentes são os embranquecimentos dos cabelos, o surgimento de rugas, o andar mais lento, a postura encurvada, a redução das capacidades auditiva e visual. Essas concepções estão ancoradas na visão de que a velhice é sinônima de declínio e morte, e, que, muitas vezes, são incorporadas pelo próprio idoso. A Medicina paliativa, ou cuidados paliativos, tem por objetivo estabelecer princípios para lidar com pacientes que apresentem doenças progressivas, avançadas e com expectativas de vida reduzida, além de idosos com comprometimentos, de forma que estes tenham qualidade de vida. Faz-se necessário quebrar o tabu imposto pelo tema morte, permitindo que esta  tome posse de seu lugar de direito: a de única certeza da vida.Palavras-chave: Envelhecimento. Morte. Saúde. Qualidade de Vida. abstract   If you ask people around us what is that opposes life, probably, the large majority will say that it is death. This dualism, confrontational, painful and contradictory, prevents us, for example, to see death as a natural process, as something that is part of life. Elderly, in its turn, is associated to changes in the body, since, in the course of time, all organisms and materials suffer wear and tear, regardless of the time required for this process to occur. The external signs, and therefore more apparent in humans are diverse, such as discolored hair, wrinkles, reduction in hearing, visual, muscular and, in some cases, cognitive ability. These concepts are anchored in the view that old age is synonymous of decline and death, and which often is incorporated by the elderly. The palliative medicine seeks to establish principles for dealing with patients with advanced progressive diseases, and seniors with impairments in order to maximize the quality of remaining life of the patient. It is necessary to break the taboo topic of death imposed by allowing it to take possession of its rightful place: the only certainty of life.   keywords: Aging. Death. Health. Quality of Life.


CRANIO® ◽  
2021 ◽  
pp. 1-11
Author(s):  
Ana Izabela Sobral De Oliveira-Souza ◽  
Laís Ribeiro Do Valle Sales ◽  
Alexandra Daniele De Fontes Coutinho ◽  
Susan Armijo Olivo ◽  
Daniella Araújo de Oliveira

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Danúbia da Cunha Sá-Caputo ◽  
Pedro Ronikeili-Costa ◽  
Rafaelle Pacheco Carvalho-Lima ◽  
Luciana Camargo Bernardo ◽  
Milena Oliveira Bravo-Monteiro ◽  
...  

Vibrations produced in oscillating/vibratory platform generate whole body vibration (WBV) exercises, which are important in sports, as well as in treating diseases, promoting rehabilitation, and improving the quality of life. WBV exercises relevantly increase the muscle strength, muscle power, and the bone mineral density, as well as improving the postural control, the balance, and the gait. An important number of publications are found in the PubMed database with the keyword “flexibility” and eight of the analyzed papers involving WBV and flexibility reached a level of evidence II. The biggest distance between the third finger of the hand to the floor (DBTFF) of a patient with metabolic syndrome (MS) was found before the first session and was considered to be 100%. The percentages to the other measurements in the different sessions were determined to be related to the 100%. It is possible to see an immediate improvement after each session with a decrease of the %DBTFF. As the presence of MS is associated with poorer physical performance, a simple and safe protocol using WBV exercises promoted an improvement of the flexibility in a patient with MS.


2004 ◽  
Vol 96 (1) ◽  
pp. 167-172 ◽  
Author(s):  
Li Chen ◽  
B. L. Grégoire Nyomba

This study examined the effects of maternal ethanol (EtOH) consumption during pregnancy or lactation on glucose homeostasis in the adult rat offspring. Glucose disposal was determined by minimal model during an intravenous glucose tolerance test in rats that had a small or normal birth weight after EtOH exposure in utero and in rats whose mothers were given EtOH during lactation only. All three EtOH groups had decreased glucose tolerance index and insulin sensitivity index, but their glucose effectiveness was not different from that of controls. In addition, EtOH rat offspring that were small at birth had elevated plasma, liver, and muscle triglyceride levels. The data show that EtOH exposure during pregnancy programs the body to insulin resistance later in life, regardless of birth weight, but that this effect also results in dyslipidemia in growth-restricted rats. In addition, insulin resistance is also evident after EtOH exposure during lactation.


2022 ◽  
Vol 164 (1) ◽  
pp. 25-26
Author(s):  
Megan Lander ◽  
Kate Dugan ◽  
Jaden Kohn ◽  
Stephanie Wethington ◽  
Edward Tanner ◽  
...  

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