MON-LB677: Effects of AU-1803 on Cholic Acid Induced-Intestinal Damage and Liver Weight Gain in Mice

2019 ◽  
Vol 38 ◽  
pp. S311
Author(s):  
T. Koda ◽  
J. Takanari ◽  
H. Imai
Keyword(s):  
Weight Gain ◽  
Cholic Acid ◽  
Liver Weight ◽  
Intestinal Damage

scholarly journals Preventive Effects of Kaempferol on High-Fat Diet-Induced Obesity Complications in C57BL/6 Mice

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Tieqiao Wang ◽  
Qiaomin Wu ◽  
Tingqi Zhao
Keyword(s):  
Insulin Resistance ◽  
Weight Gain ◽  
Blood Glucose ◽  
Gut Microbiota ◽  
Serum Cholesterol ◽  
High Fat Diet ◽  
Liver Weight ◽  
Control Group ◽  
High Fat ◽  
High Blood Glucose

Kaempferol is a dietary flavanol that regulates cellular lipid and glucose metabolism. Its mechanism of action in preventing hepatic steatosis and obesity-related disorders has yet to be clarified. The purpose of this research was to examine kaempferol’s antiobesity effects in high-fat diet- (HFD-) fed mice and to investigate its impact on their gut microbiota. Using a completely randomized design, 30 mice were equally assigned to a control group, receiving a low-fat diet, an HFD group, receiving a high-fat diet, and an HFD+kaempferol group, receiving a high-fat diet and kaempferol doses of 200 mg/kg in the diet. After eight weeks, the HFD mice displayed substantial body and liver weight gain and high blood glucose and serum cholesterol levels. However, treatment with kaempferol moderated body and liver weight gain and elevation of blood glucose and serum cholesterol and triglyceride levels. Examination of 16S ribosomal RNA showed that HFD mice exhibited decreased microbial diversity, but kaempferol treatment maintained it to nearly the same levels as those in the control group. In conclusion, kaempferol can protect against obesity and insulin resistance in mice on a high-fat diet, partly through regulating their gut microbiota and moderating the decrease in insulin resistance.

Cholic acid induced-intestinal damage is suppressed by spice-derived extracts in mice

2018 ◽  
Vol 37 ◽  
pp. S286-S287
Author(s):  
T. Koda ◽  
J. Takanari ◽  
H. Imai
Keyword(s):  
Cholic Acid ◽  
Intestinal Damage

Effects of Dietary Aroclor® 1242 on Channel Catfish (Ictalurus punctatus) and the Selective Accumulation of PCB Components

1976 ◽  
Vol 33 (6) ◽  
pp. 1343-1352 ◽  
Author(s):  
L. G. Hansen ◽  
W. B. Wiekhorst ◽  
J. Simon
Keyword(s):  
Weight Gain ◽  
Ictalurus Punctatus ◽  
Channel Catfish ◽  
Control Diet ◽  
Liver Weight ◽  
Control Fish ◽  
Histopathological Lesions ◽  
Treated Fish ◽  
Selective Accumulation

Channel catfish (Ictalurus punctatus) fingerlings fed a diet containing 20 ppm Aroclor® 1242 for 20 wk responded with a reduced weight gain and liver hypertrophy when compared to controls. When treated fish were fed the control diet for 8 subsequent wk followed by 8 additional wk of Aroclor® feed, they approached control values for liver weight and surpassed the rate of gain for control fish. No histopathological lesions were observed in the fish fed PCB. The total PCB in fish declined slightly during an 8-wk PCB-free period beginning at week 12, but the PCB burden remained constant when the PCB-free period was begun at week 20. During PCB-free periods, there was a shift in residues from the edible carcass to the offal. Residues are discussed as components as well as total PCB. We found that a tetrachlorobiphenyl is more persistent than some higher chlorinated components and that various tissues accumulated different profiles of components.

scholarly journals GAMBARAN HISTOPATOLOGI HATI TIKUS WISTAR YANG DIBERIKAN BORAKS

2014 ◽  
Vol 2 (3) ◽  
Author(s):  
Rico Lukas Tatukude ◽  
Lily Loho ◽  
Poppy M. Lintong
Keyword(s):  
Weight Gain ◽  
Fatty Liver ◽  
Wistar Rats ◽  
Liver Weight ◽  
Control Group ◽  
Liver Size ◽  
Hydropic Degeneration ◽  
Cleaning Agents ◽  
Different Doses

Abstract: Borax is an ingredient that is widely used for industrial or antiseptic cleaning agents that are toxic, but borax is used as an additive ind foods and any experience accumulated in the liver that can cause liver disfumction. Methods: The aim of  research is to see macroscopic and microscopic of live wistar rats were given different doses of borax. Rats were used as much as  10 animals were divided into 4 groups. The control group (K1) 1 rat, K2 ( borax 20mg), K3 (borax 30 mg), K4 (borax 40 mg) each of 3 rats by administration for 1,5 and 10 days. Result: The result showed the rats had grossly enlarged liver size, liver weight gain and blackish brown in the group given 40 mg of borax and microscopically, the cells were exposed to borax liver showed hydropic degeneration, proliferation fibrolas and fibrosis.  From this study it can be concluded that the administraion of borax 20mg, 30mg, 40mg for 10 days caused fatty liver and mild fibrosis. Keywords: Borax, Liver Disfunction.     Abstrak: Latar Belakang: Boraks merupakan bahan industri yang banyak digunakan untuk antiseptik atau zat pembersih. Akan tetapi boraks juga masih digunakan sebagai bahan tambahan pada makanan dan dapat memberikan efek karsinogenik dan disfungsi hati. Metode: Penelitian ini bertujuan untuk melihat gambaran histopatologi hati tikus wistar yang diberi boraks. Tikus yang digunakan sebanyak 10 ekor. Kelompok kontrol (K1) sebanyak 1 ekor tikus, K2, K3, K4 masing-masing 3 ekor tikus yang diberikan dosis 20mg, 30mg, dan 40mg yang diterminasi pada hari ke 1,5, dan 10. Hasil: Dari hasil penelitian menunjukkan secara mikroskopik sel hati yang terpapar boraks mengalami degenerasi hidropik, proliferasi fibrolas, dan secara makroskopis sel hati hewan coba mengalami perbesaran dan berwarna coklat kehitaman. Pemberian boraks 20mg, 30mg, dan 40mg dapat menyebabkan kerusakan hati. Kata Kunci: Boraks, Disfungsi Hati.

scholarly journals Realimentación por estoma distal en una serie de casos de niños con ileostomía: un posible método para facilitar la restitución del tránsito intestinal

2018 ◽  
Vol 39 (3) ◽  
pp. 216
Author(s):  
María Zornoza Moreno ◽  
José Alejandro Ruiz Montañez
Keyword(s):  
Weight Gain ◽  
Anastomotic Dehiscence ◽  
Intestinal Atresia ◽  
Normal Weight ◽  
Ileostomy Closure ◽  
Intestinal Damage ◽  
Normal Height ◽  
Perianal Dermatitis ◽  
Macroscopic Findings ◽  
Bowel Segments

OBJETIVO: exponer y describir una técnica de realimentación en niños con ileostomía que permite aumentar la curva de crecimiento y disminuir las dehiscencias anastomóticas y dermatitis posoperatoria.MATERIAL Y MÉTODOS: estudio retrospectivo de serie de casos de pacientes con ileostomía tratados con la técnica de realimentación de estoma distal, previa a la restitución del tránsito intestinal, atendidos durante el año 2014. Se revisó el padecimiento que condicionó la derivación, la edad y peso al inicio de la realimentación, ganancia ponderal, duración de la realimentación, hallazgos macroscópicos en el cierre de ileostomía y repercusiones posoperatorias.RESULTADOS: se estudiaron siete pacientes, cuatro de ellos tuvieron atresia intestinal, uno sospecha de enfermedad de Hirschsprung, otro enterocolitis y otro sufrimiento intestinal postinvaginación. La realimentación se inició a una edad media de 5 meses de vida y peso medio de 4.4 kg. La ganancia ponderal fue de 0.7 kg al mes, en promedio, (rango 0.36-1.4 kg al mes). No se encontró desproporción entre los cabos. No hubo ninguna dehiscencia anastomótica ni dermatitis perianal posoperatoria. Luego del seguimiento durante dos años, seis pacientes tienen curva ponderal y talla normal para su edad.CONCLUSIONES: la realimentación es una técnica fácil, segura y barata que permite aumentar la ganancia ponderal del paciente, evitar la atrofia del segmento intestinal, disminuir la pérdida de líquidos y electrólitos y preparar el intestino distal para la futura anastomosis.PALABRAS CLAVE: realimentación; estoma; ileostomía; cierre de la ileostomía; atresia intestinal; intestino. Abstract OBJECTIVE: To present and describe a feedback technique in children with ileostomy that allows to increase the growth curve and decrease anastomotic dehiscence and postoperative dermatitis.MATERIAL AND METHODS: We present 7 patients with ileostomy, treated with the refeeding technique during 2014 in the ColorectalCenter. We review why the derivation was performed, the age and the weight when the refeeding was begun, the weight gained, how long the refeeding was carried out, the macroscopic findings during the ileostomy closure and the outcome.RESULTS: Four patients had intestinal atresia, 1 patient was suspected of Hirschsprung's disease, one had necrotizing enterocolitis and another had an intestinal intussusception with intestinal damage. The refeeding was begun at 5 months old on average and with 4.4kg on average. The weight gain was 0.7kg per month on average (range 0.36- 1.4kg per month). We found no disproportion between the bowel segments. There was neither anastomotic dehiscence nor postoperative perianal dermatitis. After 2 years of follow-up, 6 patients have normal weight curve and normal height curve for their age.CONCLUSIONS: The refeeding is an easy, safe and inexpensive technique to increase the patient weight gain, to prevent the atrophy of the intestinal segment, to reduce fluid and electrolyte loss and to prepare the bowel for the future intestinal anastomosis.KEY WORDS: refeeding; stoma; intestinal; ileostomy; ileostomy closure; intestinal atresia, bowel.

scholarly journals CTRP12 ablation differentially affects energy expenditure, body weight, and insulin sensitivity in male and female mice

2020 ◽  
Vol 319 (1) ◽  
pp. E146-E162 ◽  
Author(s):  
Stefanie Y. Tan ◽  
Xia Lei ◽  
Hannah C. Little ◽  
Susana Rodriguez ◽  
Dylan C. Sarver ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Insulin Sensitivity ◽  
Energy Expenditure ◽  
Elevated Serum ◽  
Liver Weight ◽  
Homozygous Deletion ◽  
Whole Body ◽  
Male Mice ◽  
Female Mice

Secreted hormones facilitate tissue cross talk to maintain energy balance. We previously described C1q/TNF-related protein 12 (CTRP12) as a novel metabolic hormone. Gain-of-function and partial-deficiency mouse models have highlighted important roles for this fat-derived adipokine in modulating systemic metabolism. Whether CTRP12 is essential and required for metabolic homeostasis is unknown. We show here that homozygous deletion of Ctrp12 gene results in sexually dimorphic phenotypes. Under basal conditions, complete loss of CTRP12 had little impact on male mice, whereas it decreased body weight (driven by reduced lean mass and liver weight) and improved insulin sensitivity in female mice. When challenged with a high-fat diet, Ctrp12 knockout (KO) male mice had decreased energy expenditure, increased weight gain and adiposity, elevated serum TNFα level, and reduced insulin sensitivity. In contrast, female KO mice had reduced weight gain and liver weight. The expression of lipid synthesis and catabolism genes, as well as profibrotic, endoplasmic reticulum stress, and oxidative stress genes were largely unaffected in the adipose tissue of Ctrp12 KO male mice. Despite greater adiposity and insulin resistance, Ctrp12 KO male mice fed an obesogenic diet had lower circulating triglyceride and free fatty acid levels. In contrast, lipid profiles of the leaner female KO mice were not different from those of WT controls. These data suggest that CTRP12 contributes to whole body energy metabolism in genotype-, diet-, and sex-dependent manners, underscoring complex gene-environment interactions influencing metabolic outcomes.

Acceptability of Rapeseed Proteins in Diets of Rainbow Trout (Salmo gairdneri)

1978 ◽  
Vol 35 (7) ◽  
pp. 951-962 ◽  
Author(s):  
M. Yurkowski ◽  
J. K. Bailey ◽  
R. E. Evans ◽  
Jo-Anne L. Tabachek ◽  
G. Burton Ayles ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Rainbow Trout ◽  
Weight Gain ◽  
Liver Weight ◽  
Rapeseed Meal ◽  
Economic Benefits ◽  
The Body ◽  
Feed Consumption ◽  
Salmo Gairdneri ◽  
Rapeseed Proteins

Weight gain and feed consumption results showed that rapeseed protein concentrate (RPC) and rapeseed meal (RM) can be substituted for soybean meal (SM) and perhaps partially for herring meal (HM) in rainbow trout (Salmo gairdneri) control (SM–HM) diet and thus have economic benefits. Rapeseed flour (RF) was a poor source of proteins due to its greater effect on thyroid function. Rapeseed proteins have little effect on liver weight, body moisture, liver and body lipid, liver and body sterol content, visual and histological appearance of liver, heart and visceral tissues, or on the flavor, but caused yellow pigmentation of the skin. The levels of individual fatty acids in the diets directly affected the levels of individual fatty acids in the liver and body, while the type and level of dietary rapeseed proteins appeared to have no effect. The levels of fatty acids, 20:1 and 22:1 (includes erucic acid), were lower in the body and even lower in the liver compared with the diets. All test diets, except RPC–HM diet, caused marked thyroid hyperplasia, believed to be due to glucosinolates (goitrogens). However, some compensation for this goitrogenic action must occur because plasma T4 levels indicated a hypothyroid state for only five test diets (highest RPC-containing diet; highest RM-containing diet; all three RF-containing diets). Key words: dietary rapeseed, glucosinolates, feed–gain ratios, growth, lipids, fatty acids, plasma T4, thyroid histology, flavor, weight gain

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