Low-protein diet promotes sodium chloride-enhanced gastric carcinogenesis induced by N-methyl-N′-nitro-N-nitrosoguanidine in Wistar rats

1999 ◽  
Vol 141 (1-2) ◽  
pp. 117-122 ◽  
Author(s):  
Hiroyasu Iishi ◽  
Masaharu Tatsuta ◽  
Miyako Baba ◽  
Ryuto Hirasawa ◽  
Noriko Sakai ◽  
...  
Keyword(s):  
Sodium Chloride ◽  
Wistar Rats ◽  
Gastric Carcinogenesis ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein

Enhanced induction of colon carcinogenesis by azoxymethane in wistar rats fed a low-protein diet

1992 ◽  
Vol 50 (1) ◽  
pp. 108-111 ◽  
Author(s):  
Masaharu Tatsuta ◽  
Hiroyasu Iishi ◽  
Miyako Baba ◽  
Haruo Taniguchi
Keyword(s):  
Wistar Rats ◽  
Colon Carcinogenesis ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein

scholarly journals BIOCHEMICAL EFFECT OF A HIGH DOSE OF THAUMATIN IN WISTAR RATS

2016 ◽  
Vol 9 (1) ◽  
pp. 304
Author(s):  
Warid Khayata ◽  
Ahmad Kamri ◽  
Rasha Alsaleh
Keyword(s):  
Body Weight ◽  
Glucose Tolerance ◽  
Total Protein ◽  
Wistar Rats ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Oral Glucose ◽  
High Dose ◽  
High Carbohydrate ◽  
Low Protein

<p><strong>Objective: </strong>The aim of this work was to investigate the capability of a high dose of thaumatin; a sweet tasting protein, of improving induced protein malnutrition in male Wistar rats.</p><p><strong>Methods: </strong>For this study, 12 rats were divided into 2 groups and treated orally along with a high-carbohydrate, low-protein diet as follows: water group as a negative control, and thaumatin group at a dose of 464 mg/kg for 3 consecutive w. Blood samples were collected to analyse glucose, triglycerides, total cholesterol, and total protein, and body weight was measured. An oral glucose tolerance test (OGTT) was carried out at the end of the experiment.</p><p><strong>Results: </strong>Despite the high amount of<strong> </strong>thaumatin used, only a slight increase in blood glucose occurred and was within the normal range, whereas serum triglycerides and cholesterol decreased significantly unlike control. Body weight had declined in both groups due to a low-protein diet, while total protein and glucose tolerance remained unchanged.</p><strong>Conclusion: </strong>It is found that<strong> </strong>thaumatin is safe to consume by Wistar rats even at high doses. Besides that high-carbohydrate, low-protein diet caused falling of body weight, it had drawbacks of increased triglycerides and cholesterol levels which can be useful to create animal models of abnormal lipid metabolism without obesity. However, simultaneous ingestion of thaumatin with this diet had altered the outcomes to the best case. In future, it may be possible to use this combination for achieving healthy eating patterns without drug intervention that is needed for obese patients with various dysglycemia or dyslipidemia manifestations and people following regimes for weight reduction.<p> </p>

A maternal low-protein diet and neonatal overnutrition result in similar changes to glomerular morphology and renal cortical oxidative stress measures in male Wistar rats

2019 ◽  
Vol 44 (2) ◽  
pp. 164-171 ◽  
Author(s):  
Anderson Pedroza ◽  
Diorginis Soares Ferreira ◽  
David F. Santana ◽  
Pedro Thiago da Silva ◽  
Francisco Carlos Amanajás de Aguiar Júnior ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Renal Cortex ◽  
Protein Diet ◽  
Antioxidant Defenses ◽  
Low Protein Diet ◽  
Low Protein ◽  
Oxidative Balance ◽  
Male Wistar Rats ◽  
Glomerular Morphology

There is a strong correlation between inadequate gestational and postpartum nutrition and the occurrence of cardiovascular diseases. The present study investigated the effects of a maternal low-protein diet and neonatal overfeeding on the oxidative balance and morphology of the renal cortex of male Wistar rats. Two independent protocols were used. First, pregnant Wistar rats received diets containing either 17% (normal protein) or 8% (low protein) casein throughout pregnancy and lactation. Second, the litter size was reduced by one-third on the third postnatal day to induce overnourishment in offspring. At 30 days, the oxidative balance and morphology of the renal cortex were analyzed. There was a small but significant increase in renal corpuscle area in the low protein (LP, 5%) and overnutrition (ON, 8%) groups. Glomerular tuft area also increased in LP (6%) and ON (9%), as did glomerular cellularity (LP, +11%; ON, +12%). In the oxidative stress analyses, both nutritional insults significantly elevated lipid peroxidation (LP, +18%; ON, +135%) and protein oxidation (LP, +40%; ON, +65%) while significantly reducing nonenzymatic antioxidant defenses, measured as reduced glutathione (LP, –32%; ON, –45%) and total thiol content (LP, –28%; ON, –24%). We also observed a decrease in superoxide dismutase (LP, –78%; ON, –51%), catalase (LP, –18%; ON, –61%), and glutathione S-transferase (only in ON, –44%) activities. Our results demonstrate that nutritional insults, even those of a very different nature, during perinatal development can result in similar changes in oxidative parameters and glomerular morphology in the renal cortex.

scholarly journals The 17β-oestradiol treatment minimizes the adverse effects of protein restriction on bone parameters in ovariectomized Wistar rats

2019 ◽  
Vol 8 (12) ◽  
pp. 573-581 ◽  
Author(s):  
Victoria P. de Quadros ◽  
Natalia Tobar ◽  
Lais R. Viana ◽  
Rogerio W. dos Santos ◽  
Paulo H. M. Kiyataka ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Bone Mass ◽  
Wistar Rats ◽  
Protein Restriction ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Hormone Deficiency ◽  
Mineral Density ◽  
Bone Parameters ◽  
Low Protein

Objectives Insufficient protein ingestion may affect muscle and bone mass, increasing the risk of osteoporotic fractures in the elderly, and especially in postmenopausal women. We evaluated how a low-protein diet affects bone parameters under gonadal hormone deficiency and the improvement led by hormone replacement therapy (HRT) with 17β-oestradiol. Methods Female Wistar rats were divided into control (C), ovariectomized (OVX), and 17β-oestradiol-treated ovariectomized (OVX-HRT) groups, which were fed a control or an isocaloric low-protein diet (LP; 6.6% protein; seven animals per group). Morphometric, serum, and body composition parameters were assessed, as well as bone parameters, mechanical resistance, and mineralogy. Results The results showed that protein restriction negatively affected body chemical composition and bone metabolism by the sex hormone deficiency condition in the OVX group. The association between undernutrition and hormone deficiency led to bone and muscle mass loss and increased the fragility of the bone (as well as decreasing relative femoral weight, bone mineral density, femoral elasticity, peak stress, and stress at offset yield). Although protein restriction induced more severe adverse effects compared with the controls, the combination with HRT showed an improvement in minimizing these damaging effects, as it was seen that HRT had some efficacy in maintaining muscle and bone mass, preserving the bone resistance and minimizing some deleterious processes during the menopause. Conclusion Protein restriction has adverse effects on metabolism, leading to more severe menopausal symptoms, and HRT could minimize these effects. Therefore, special attention should be given to a balanced diet during menopause and HRT. Cite this article: Bone Joint Res 2019;8:573–581.

scholarly journals Renal responses of reindeer to high and low protein diet and sodium supplement

1979 ◽  
Vol 51 (1) ◽  
pp. 381-419 ◽  
Author(s):  
Maija Valtonen
Keyword(s):  
Sodium Chloride ◽  
Urine Osmolality ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Plasma Urea ◽  
Urea Excretion ◽  
Low Protein ◽  
Urea Reabsorption ◽  
Solute Excretion ◽  
Sodium Chloride Intake

The effects of reducing dietary nitrogen and increasing sodium chloride intake on renal function were studied in reindeer in order so elucidate the extent of urea conservation and solute excretion by the reindeer kidney. The fall in plasma urea concentration and urea excretion on the low protein diet was accompanied by a significant reduction in the glomerular filtration rate (GFR) and urine osmolality. The fraction of filtered urea reabsorbed increased. However, the contribution of the fall of the GFR to restriction of urinary losses of urea was far more significant than the increase in fractional urea reabsorption. The increase in sodium chloride intake reflected in icreased urinary sodium excretion, inducing a rise in urine osmolality on the low protein diet. Increased excretion of sodium was accompanied by decreased urea excretion. This interdependence of urea and sodium in urine excretion was particularly pronounced during the mating season in the autumn, when prominent retention of electrolytes and water was observed. On low protein diet, when reindeer were exposed to cold, the energy intake proved insufficient. The use of body protein as energy source resulted in increased plasma urea values. The fractional reabsorption of urea decreased, but the GFR stayed low. The GFR seems to be unaffected by plasma urea concentrations but is in some way regulated by the intake of dietary protein. Also on lichen diet the intake was not sufficient to satisfy the energy requirements and the plasma urea concentrations increased. The urea excretion was still low due to a decreased GFR. The high moisture content of lichen caused an increase in the urine water excretion, but no increase occured in the solute excretion. The rumen ammonia concentrations correlated significantly with the plasma urea concentrations, showing that urea is readily returned to the rumen in reindeer. The restriction of urea excretion on low protein intake contributes to the nitrogen economy and in reindeer it is brought about by a marked decrease in the GFR together with an increase in the urea reabsorption.

Effect of Combined Excess Iodine and Low-Protein Diet on Thyroid Hormones and Ultrastructure in Wistar Rats

2013 ◽  
Vol 155 (3) ◽  
pp. 416-422 ◽  
Author(s):  
Jie Gao ◽  
Xinying Lin ◽  
Xihua Liu ◽  
Qun Yang ◽  
Zhijie Zhang ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Wistar Rats ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Excess Iodine ◽  
Low Protein

FACTORS IN THE REDUCED SURVIVAL TIME DURING STARVATION IN THE COLD OF RATS PREVIOUSLY FED A LOW-PROTEIN DIET

1964 ◽  
Vol 42 (4) ◽  
pp. 533-545 ◽  
Author(s):  
J. R. Beaton ◽  
V. Feleki ◽  
J. A. F. Stevenson
Keyword(s):  
Oxygen Consumption ◽  
Food Consumption ◽  
Water Loss ◽  
Wistar Rats ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Sprague Dawley ◽  
Low Protein ◽  
Sprague Dawley Rats ◽  
Male Wistar Rats

Male Wistar rats fed a low-protein diet (5% by weight) did not withstand subsequent deprivation of food at 5 °C or 23 °C as long as controls that had been fed a 20% protein diet isocalorically. This was also true in Sprague–Dawley rats which were studied only at 5 °C. This effect of the low-protein diet was not attributable to differences in food consumption, or in "resting" oxygen consumption. The rats fed low-protein had somewhat less fat when deprived of food but, perhaps more importantly, appeared to use less of their reserves of energy during food deprivation. Apparent water loss and thus dehydration appeared to be greater in these animals.

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