Repeated measurements designs for a model with self and simple mixed carryover effects

2002 ◽  
Vol 106 (1-2) ◽  
pp. 449-459 ◽  
Author(s):  
K. Afsarinejad ◽  
A.S. Hedayat
Keyword(s):  
Repeated Measurements ◽  
Carryover Effects

scholarly journals Bayesian Analysis of an Optimal Five Period Cross-over Design

2021 ◽  
pp. 123-130
Author(s):  
Cornelious Omwando Nyakundi ◽  
Isaac Kipkosgei Tum
Keyword(s):  
Bayesian Analysis ◽  
Bayesian Method ◽  
Repeated Measurements ◽  
Unbiased Estimation ◽  
Experimental Unit ◽  
Carryover Effects ◽  
Significant Treatment ◽  
Analysis Methods ◽  
Carry Over ◽  
Highest Posterior Density

A crossover design is a repeated measurements design such that each experimental unit receives different treatments during the different time periods. In a majority of bioequivalence studies, design and analysis of cross-over using classical methods such as analysis of variance (ANOVA) and test are normally associated with erroneous results. The Bayesian method is desirable in the analysis of crossover designs to eliminate errors associated with carryover effects. The objective of this study was to compare the Bayesian and the - test analysis methods on treatments and carryover effects for an optimal two treatments, five periods and four sequence C (2, 5, 4) design. The treatments and residual estimates were obtained using Best Linear Unbiased Estimation (BLUE) method. In the Bayesian method of analysis, the posterior quantities were obtained for the mean intervals of treatments and carry-over effects and the highest posterior density (HPD) graphs were plotted and interpreted using conditional probability statements. For validation purposes, the Bayesian method results were compared with the existing -tests results. From the Bayesian analysis, the probability of significant treatment difference in the presence of carryover effects was 1, while from the -test, the calculated value of 11.73 was greater than the two sided tabulated value at 95  level of significance. The two analysis methods implied significant differences in the treatment effects. In conclusion, it was established that Bayesian method of analysis can be used for bioequivalence analysis even when the carry-over effects are present and hence it is highly recommended for bioequivalence studies.

Modeling Intraindividual Variability in Three-Level Multilevel Models

Methodology ◽  
2018 ◽  
Vol 14 (3) ◽  
pp. 95-108 ◽  
Author(s):  
Steffen Nestler ◽  
Katharina Geukes ◽  
Mitja D. Back
Keyword(s):  
Multilevel Model ◽  
Multilevel Models ◽  
Mixed Effects ◽  
Repeated Measurements ◽  
Scale Model ◽  
Suggested Approach ◽  
Psychological Study ◽  
Level Data ◽  
Ecological Momentary ◽  
Momentary Assessment

Abstract. The mixed-effects location scale model is an extension of a multilevel model for longitudinal data. It allows covariates to affect both the within-subject variance and the between-subject variance (i.e., the intercept variance) beyond their influence on the means. Typically, the model is applied to two-level data (e.g., the repeated measurements of persons), although researchers are often faced with three-level data (e.g., the repeated measurements of persons within specific situations). Here, we describe an extension of the two-level mixed-effects location scale model to such three-level data. Furthermore, we show how the suggested model can be estimated with Bayesian software, and we present the results of a small simulation study that was conducted to investigate the statistical properties of the suggested approach. Finally, we illustrate the approach by presenting an example from a psychological study that employed ecological momentary assessment.

Use of a Lyophilized Reference Plasma to Compare Coagulation Test Procedures

1975 ◽  
Vol 34 (02) ◽  
pp. 426-444 ◽  
Author(s):  
J Kahan ◽  
I Nohén
Keyword(s):  
Oral Anticoagulant Therapy ◽  
Repeated Measurements ◽  
Test Procedures ◽  
Coagulation Activity ◽  
Close Relationship ◽  
Measured Activity ◽  
Test Materials ◽  
The Difference ◽  
The Stability ◽  
The One

SummaryIn 4 collaborative trials, involving a varying number of hospital laboratories in the Stockholm area, the coagulation activity of different test materials was estimated with the one-stage prothrombin tests routinely used in the laboratories, viz. Normotest, Simplastin-A and Thrombotest. The test materials included different batches of a lyophilized reference plasma, deep-frozen specimens of diluted and undiluted normal plasmas, and fresh and deep-frozen specimens from patients on long-term oral anticoagulant therapy.Although a close relationship was found between different methods, Simplastin-A gave consistently lower values than Normotest, the difference being proportional to the estimated activity. The discrepancy was of about the same magnitude on all the test materials, and was probably due to a divergence between the manufacturers’ procedures used to set “normal percentage activity”, as well as to a varying ratio of measured activity to plasma concentration. The extent of discrepancy may vary with the batch-to-batch variation of thromboplastin reagents.The close agreement between results obtained on different test materials suggests that the investigated reference plasma could be used to calibrate the examined thromboplastin reagents, and to compare the degree of hypocoagulability estimated by the examined PIVKA-insensitive thromboplastin reagents.The assigned coagulation activity of different batches of the reference plasma agreed closely with experimentally obtained values. The stability of supplied batches was satisfactory as judged from the reproducibility of repeated measurements. The variability of test procedures was approximately the same on different test materials.

REPEATED MEASUREMENTS WITH THE WISC

1962 ◽  
Vol 11 (6) ◽  
pp. 418 ◽  
Author(s):  
ROGER REGER
Keyword(s):  
Repeated Measurements

Calorimetric Sensor for Ethanol Using Ni2+-nitrilotriacetic Acid (NTA) Resin Immobilized Alcohol Dehydrogenase (ADH)

2020 ◽  
Vol 16 (6) ◽  
pp. 795-799
Author(s):  
YongJin Li
Keyword(s):  
Cost Effective ◽  
Nitrilotriacetic Acid ◽  
Repeated Measurements ◽  
Great Promise ◽  
Calorimetric Sensor ◽  
Controlled Pore Glass ◽  
Pore Glass ◽  
One Step ◽  
Immobilization Matrix ◽  
Enzyme Thermistor

Background: A simple, fast and economic analytical method for the determination of ethanol is important for clinical, biological, forensic and physico-legal purposes. Methods: Ni2+-NTA resin was used as an immobilization matrix for the simple one-step purification/ immobilization of his6-tagged ADH. Different alcohols with a concentration range of 0.5-50% V/V, namely methanol, ethanol and propanol were measured using prepared ADH enzyme thermistor. The ethanol content of Tsingtao beer was tested as a real sample containing alcohol. Reproducibility and stability of prepared ADH enzyme thermistor were also investigated by repeated measurements. Results: In comparison to the controlled pore glass (a common used support for the immobilization of enzyme) used in thermal biosensor, the use of Ni2+-NTA resin not only led to simple one-step purification/ immobilization by his6-tagged ADH binding to Ni2+-NTA resin, but also made the immobilizing supports reusable. The prepared biosensor can be used to determine ethanol and methanol by the calorimetric measurement. A linear range of 1 -32% (V/V) and 2-20% (V/V) was observed for ethanol and methanol, respectively. The detection limits were 0.3% (V/V) and 1% (V/V) for ethanol and methanol, respectively. The tested ethanol concentration of Tsingtao beer was 4.5% V/V, which is comparable with the labeled alcohol by volume (ABV) 4.80%. Conclusion: Ni2+-NTA resin, as an immobilization matrix in ET sensor, provides a simple one-step purification/immobilization for His6-tagged recombinase and a reusable immobilization matrix. The prepared biosensor exhibits good repeatability and stability. Such a new biosensor shows great promise for rapid, simple, and cost-effective analysis of ethanol and methanol, both in qualitative and in quantitative tests.

Effect of Cash Transfer on School Dropout Rates using Longitudinal Data Modelling: A Randomized Trial of Research Initiative to Support the Empowerment of girls (RISE) in Zambia

2018 ◽  
Vol 11 (1) ◽  
pp. 507-515
Author(s):  
Mutale Sampa ◽  
Choolwe Jacobs ◽  
Patrick Musonda
Keyword(s):  
Randomized Trial ◽  
Adolescent Girls ◽  
Protective Factor ◽  
School Dropout ◽  
Cash Transfers ◽  
Repeated Measurements ◽  
Cash Transfer ◽  
Dropout Rates ◽  
Research Initiative ◽  
Rural Zambia

Background: School dropout rates, as well as early marriages and pregnancies, are high among adolescent girls in rural Zambia. In the quest to fight this, the Research Initiative to Support the Empowerment of girls (RISE) trial has been providing cash transfers and community dialogues to adolescent girls in rural Zambia. The overall goal of the study was to establish the effects of cash transfers on adolescent girls’ school dropout rates in selected provinces of Zambia. Methods: The study was nested in the RISE trial which is a cluster randomized trial conducted in Central and Southern provinces of Zambia. A total of 3500 adolescent girls were included in the study. Random intercepts model was used to model the individual effects estimates, taking account of the dependency that was likely to occur due to the repeated measurements and clustering in the study. Results: Girls who were married or cohabiting and girls who had given birth, were significantly less likely to be in school (OR=0.004, 95% CI {0.001-0.02}, p-value=<0.0001) and (OR=0.003, 95% CI {0.02-0.04}, p-value=<0.0001) respectively. Consistently receiving cash transfers increased the chance of a girl being in school (OR=8.51, 95% CI {4.50-16.08}, p-value=<0.0001). There was an indication that the combined intervention arm had a reduced chance of girls being in school, however, we could not rule out chance finding (OR=0.89, 95% CI {0.59-1.36}, p=0.606). Conclusion: The study found that marriage or cohabiting and giving birth whilst in school reduce the chances of the girl continuing schooling. No significant association could be attributed to the type of intervention, However, consistent receipt of cash transfers was shown to be a protective factor of school dropout rates in the study.

Hydrogeology correction in the gravitational field from satellite data

2018 ◽  
Vol 931 (1) ◽  
pp. 2-7
Author(s):  
V.D. Jushkin ◽  
L.V. Zotov ◽  
O.A. Khrapenko
Keyword(s):  
Gravitational Field ◽  
Oil And Gas ◽  
Repeated Measurements ◽  
Geological Factors ◽  
Grace Satellite ◽  
Gas Pumping ◽  
Acceleration Of Gravity ◽  
Determination Of Parameters ◽  
Gravity Acceleration

The results of repeated measurements of the acceleration of gravity by the Russian absolute ballistic field gravimeter GABL-M on points of oil and gas deposits in the permafrost over a five year period are presented. The changes of gravity acceleration by the absolute gravimeter and GRACE satellite were compared. The results of comparisons of differences gravity acceleration by ballistic gravimeter GABL-M and relative Canadian gravimeters CG5 were [i]shown. The errors in determination of parameters of the gravitational field ballistic gravimeter GABL-M and CG5 gravimeters group were presented. The method of measurement with the gravimeter GABL-M and the method of determining the vertical gradients relative CG5 gravity meters was described. The necessity of introducing corrections of hydrogeology is caused by influence of hydro geological factors on the gravitational field in the permafrost. They are comparable with the values of the field change in the result of gas pumping.

Sign in / Sign up

Export Citation Format

Share Document