Effect of selegiline augmentation with antipsychotic drugs on treatment of the negative symptoms in patients with schizophrenic disorder

2011 ◽  
Vol 26 (S2) ◽  
pp. 1486-1486
Author(s):  
F. Ranjbar ◽  
M. Sabagh Razavi ◽  
M.A. Ghorayshizadeh ◽  
J. Shokri ◽  
M. Asadlo
Keyword(s):  
Negative Symptoms ◽  
Antipsychotic Drugs ◽  
Intervention Group ◽  
Control Group ◽  
Control Groups ◽  
Double Blind ◽  
Significant Difference ◽  
Schizophrenic Patients ◽  
The Difference ◽  
And Control

IntroductionConsidering the shortcomings of antipsychotics in treatment of negative symptoms of schizophrenic patients, the use of augmentation treatment for decreasing the negative symptoms is highly important.AimsThe aim of this research was to study the effect of selegiline augmentation with antipsychotic drugs in decreasing the negative symptoms of schizophrenic patients.MethodsIn this double blind randomized control trial study 70 schizophrenic in- patients who were under treatment with antipsychotics were randomly divided into two intervention and control groups. The patients of both groups were given placebo for two weeks along with antipsychotics. For 12 weeks the intervention group was given selegiline 10 mg/day and control group was given placebo. The patients were evaluated with PANSS scale and Hamilton depression test at the end of first and second weeks and then at the end of every other week for twelve weeks. Then the results were analyzed statistically.ResultsThere was no significant difference between intervention and control groups considering PANSS score on first and second weeks, but the difference on 4-14 weeks was statistically significant. There was also no statistically significant difference in Hamilton depression Test between the two groups in first to 10 Th weeks. But the difference was statistically significant in 12–14 weeks.ConclusionsAugmentation treatment with selegiline can improve the negative symptoms of schizophrenic patients.

scholarly journals The Effect of Vitamin B6 on Reducing the Number and the Size of Breast Cysts and the Amount of Recurrence after Aspiration in Women

2019 ◽  
pp. 1-7
Author(s):  
Setareh Soltany ◽  
Hamid Reza Hemmati ◽  
Jafar Alavy Toussy ◽  
Parisa Alavi Toosi
Keyword(s):  
Vitamin B6 ◽  
Intervention Group ◽  
Control Group ◽  
Control Groups ◽  
Double Blind ◽  
Breast Cyst ◽  
The Difference ◽  
Palpable Breast ◽  
Breast Lumps ◽  
And Control

Introduction: Palpable breast lumps are one of the most prevalent breast problems in women who visit a doctor. Most of these lumps are benign, and many of these benign lumps, have cystic nature. One of the suggested treatments for breast cyst is vitamin B6 intake. So, this study aimed to determine the effect of vitamin B6 on reducing the number and the size of breast cysts and reducing the amount of recurrence after aspiration. Materials and Methods: This study is a double-blind randomized clinical trial. Patients simply divided into two groups randomly, intervention group (receiving 150 mg vitamin B6 twice a day for two months) and control group (placebo). After data collection, the database produced, and information came in by SPSS-22 software. Descriptive results extracted in the form of tables and graphs. In all cases was used α=0.05. Results: At the end of the study, 65 patients (34 people in the intervention group, and 31 people in the control group) studied. At the end of the survey in the non-palpable cysts, was observed a significant decrease in the number and the size of breast cysts in each group receiving vitamin B6 or placebo. Still, the difference was not significant in comparing the two groups. 19 patients (2.29%) had palpable cysts that aspiration performed in all cases. After the study period, no recurrence of cysts observed in any of the intervention and control groups. Conclusion: The study showed that vitamin B6 had no effect on reducing the size and the number of non-palpable breast cysts and prevent recurrence of palpable cysts after aspiration.

The Effect of Humor Intervention Program on Positive and Negative Symptoms among Schizophrenic Patients

2021 ◽  
Vol 15 (7) ◽  
pp. 2022-2028
Author(s):  
Eman Asran Mohamed ◽  
Enayat Abd El Wahab Khalil ◽  
Zeinab Abd El Halim Osman ◽  
Mona Rakhawy ◽  
Naglaa Mostafa G
Keyword(s):  
Intervention Program ◽  
Negative Symptoms ◽  
Demographic Data ◽  
Intervention Group ◽  
University Hospital ◽  
Control Group ◽  
Significant Difference ◽  
Schizophrenic Patients ◽  
And Control ◽  
Positive And Negative Symptoms

Background: Schizophrenia is a chronic disease characterized by distortions in thinking, perception, emotions, language, sense of self and behavior. Humor could be used as an alternative to conventional treatment with the goal of helping patients with schizophrenia cope with symptoms, enhance recovery through its emotional, cognitive, social and physiological effects. The aim of the study was to evaluate the effect of humor intervention program on positive and negative symptoms among schizophrenic patients. Design: Randomized control trial (RCT) design was used. Sample: Purposive sample consisted of 40) schizophrenic patients, the study group (n= 20) and control group (n= 20). The patients were selected and allocated randomly into two groups, intervention group (received the humor interventions program) and control group (received traditional care). The study conducted in the Psychiatry and Addiction Prevention "El Kasr AlAini University Hospital and al Rakhawy Hospital for Mental Health. Tools: three tools were used for data collection were; the Socio Demographic Data Sheet, Positive and Negative Syndrome Scale (PANSS) and Multidimensional Sense of Humor Scale (MSHS). Results: revealed that, there was a statistical significant difference between total score of PANSS between study and control groups post intervention. Conclusion: The present study emphasizes the importance of humor intervention program in reducing severity of symptoms of patients with schizophrenia. Key words: schizophrenia, humor intervention, positive symptoms, negative symptoms

scholarly journals The effects of pulsatile flushing on phlebitis and peripheral intravenous catheters patency

2020 ◽  
pp. 16-25
Keyword(s):  
Clinical Setting ◽  
Intervention Group ◽  
Practical Method ◽  
Control Group ◽  
Control Groups ◽  
Double Blind ◽  
Double Blind Clinical Trial ◽  
Significant Difference ◽  
And Control ◽  
Intravenous Catheters

Background and Aim: Thrombophlebitis is considered as a major cause of peripheral intravenous catheters (PICs) failure. The flushing technique in the laboratory has been effective in clearing the catheter duct, but its effectiveness in the clinical setting is unknown, therefore, the aim of this study was to determine the effect of pulsatile flushing on phlebitis, type, and duration of PICs patency in patients. Materials and Methods: In this double-blind clinical trial, 71 patients admitted to the inpatient and surgical wards of Imam Khomeini Esfarayen Hospital were randomly assigned to the intervention and control groups after sampling by available methods. In the intervention group, the flushing technique was performed by injecting 1 ml of the normal saline solution for one second, then interrupting less than one second and repeating the injection and interrupting until the end of 5 ml of the solution. The Consequences of this study were phlebitis, duration, and type of PICs patency, which were evaluated every 12 hours by using Jackson's phlebitis instrument and direct observation of the catheter. Results: The incidence of phlebitis in the intervention group was lower than the control group (P<0.001). In addition, two groups had a statistically significant difference in the type of PICs (P<0.001). The median duration of PICs patency in the intervention group was significantly higher than the control group (P<0.001). Conclusion: Pulsatile flushing is an effective technique to increase longevity of PICs and recommended as a practical method in clinical setting.

scholarly journals Effect of Aerobic Exercise in Positive and Negative Symptoms in Schizophrenia

2021 ◽  
Vol 9 (T3) ◽  
pp. 178-181
Author(s):  
Nazli Mahdinasari Nasution ◽  
Elmeida Effendy ◽  
Mustafa Mahmud Amin ◽  
Ice Ratnalela Siregar
Keyword(s):  
Mental Health ◽  
Physical Therapy ◽  
Aerobic Exercise ◽  
Negative Symptoms ◽  
Intervention Group ◽  
Control Group ◽  
Significant Difference ◽  
Schizophrenic Patients ◽  
And Control ◽  
The Impact

BACKGROUND: Schizophrenia is a severe mental disorder that impacts on the individual and society. It is characterized by positive, negative, cognitive, affective, and aggressive symptoms. This condition has a detrimental influence on the ability of schizophrenic patients to work across all facets of everyday life, making it a significant clinical goal that cannot be handled with antipsychotics in a sufficient manner. The International Organization of Physical Therapy in Mental Health has confirmed that physical therapy helps to improve physical mental health and quality of life in multidisciplinary care for people with schizophrenia. AIM: The aim of this study is to see the impact of aerobic exercise on schizophrenic patients. PATIENTS AND METHODS: This study was conducted at Prof. Dr. M. Ildrem Mental Hospital in 2016. Methods: 34 female chronic schizophrenic patients included in this study. They divided into two groups: Intervention and control group. The intervention group was given aerobic exercise, 3 times a week for 8 weeks. RESULTS: We obtained a significant difference change in positive and negative scores of positive and negative syndrome scales between intervention group and control group (p < 0.001). CONCLUSION: There is a significant change in positive and negative score of PANSS between intervention group and control group.

Somatosensory Evoked Potentials in Schizophrenia a Lateralisation Study

1990 ◽  
Vol 157 (6) ◽  
pp. 881-887 ◽  
Author(s):  
Paul Furlong ◽  
Paul Barczak ◽  
Gwilym Hayes ◽  
Graham Harding
Keyword(s):  
Index Finger ◽  
Objective Measure ◽  
Control Group ◽  
Temporal Region ◽  
Control Groups ◽  
Significant Difference ◽  
Schizophrenic Patients ◽  
Left And Right ◽  
And Control ◽  
Stimulation Of

The SSEPs obtained from 19 schizophrenics defined by RDC, DSM–III and PSE criteria Were compared with those from a control group of healthy volunteers. Previous findings of an abnormal lack of lateralising response in schizophrenic patients were not replicated. No significant difference in either amplitude or morphology between the traces obtained from the two groups were recorded. Ipsilateral and contralateral latencies for stimulation of the left and right index finger showed no significant difference in peak latency for any component between patient and control group. When mean peak-to-peak amplitudes were plotted the contralateral component was always greater in amplitude than the ipsilateral one. An objective measure of the degree of lateralisation, the percentage lateralisation quotient, showed no lateralisation differences between the patient and control groups. A case of myogenic contamination of ipsilateral components was observed calling into doubt findings where no temporal region monitoring has been performed.

Effects of Mindfulness-Based Psychoeducation on the Internalized Stigmatization Level of Patients With Schizophrenia

2018 ◽  
Vol 29 (7) ◽  
pp. 496-503 ◽  
Author(s):  
Emine Yılmaz ◽  
Funda Kavak
Keyword(s):  
Health Centers ◽  
Control Group ◽  
Community Mental Health Centers ◽  
Control Groups ◽  
Face To Face ◽  
Significant Difference ◽  
The Difference ◽  
Mental Health Centers ◽  
And Control ◽  
Experimental Group

The aim of this study was to determine the effects of mindfulness-based psychoeducation on internalized stigma in patients with schizophrenia. The patients were recruited from the community mental health centers. This quasiexperimental study was conducted using pretests and posttests with a control group. The participants were 69 patients with schizophrenia; 34 were part of the experimental group and 35 were part of the control group. The patients in the experimental group participated 2 days a week for 6 weeks in a total of 12 sessions which were given in the form of face-to-face group training. The difference between the scale mean posttest scores of the patients in the experimental and control groups was found to be statistically significant ( p < .05). In the intragroup comparisons, a significant difference was found between the stigma mean scores in the experimental group ( p < .05). It was concluded that mindfulness-based psychoeducation was effective in reducing stigma in patients with schizophrenia.

scholarly journals Efficacy of a herbal toothpaste on patients with established gingivitis: a randomized controlled trial

2006 ◽  
Vol 20 (2) ◽  
pp. 172-177 ◽  
Author(s):  
Fabiana Ozaki ◽  
Claudio Mendes Pannuti ◽  
Ana Vitória Imbronito ◽  
Wellington Pessotti ◽  
Luciana Saraiva ◽  
...  
Keyword(s):  
Adverse Reactions ◽  
Controlled Trial ◽  
Test Group ◽  
Experimental Period ◽  
Positive Control ◽  
Control Group ◽  
Control Groups ◽  
Double Blind ◽  
Significant Difference ◽  
And Control

The aim of this randomised, double blind controlled trial was to verify the efficacy of a herbal dentifrice on the reduction of plaque and gingivitis. Forty eight volunteers with established gingivitis were randomly assigned to either a test group (herbal dentifrice) or positive control group (dentifrice with triclosan and fluoride). The dentifrices were distributed in plain white tubes by an independent pharmacy, which revealed the contents of each tube only after the experimental period. Plaque and gingivitis assessments were carried out on baseline and after 28 days of product use. All examinations were conducted by the same calibrated investigator. Subjects were instructed to brush their teeth three times daily using their assigned dentifrice for 28 days. There was a significant reduction in plaque levels in both the test and control groups. However, there was no significant difference between the groups. A significant reduction in gingivitis was observed in both groups, although there was no significant difference between them. No adverse reactions were reported. The authors concluded that both dentifrices were effective in reducing plaque and gingivitis in subjects with established gingivitis.

scholarly journals The Effect of Cognitive- Behavioral Counseling on the Sexual Compatibility of New Married Couples: A Clinical Trial Study 

2020 ◽  
Author(s):  
Parvin Allahyari ◽  
Mitra Kolivand ◽  
Arash Namdari ◽  
Khaled Rahmani
Keyword(s):  
Intervention Group ◽  
Married Couples ◽  
Cognitive Behavioral ◽  
Control Group ◽  
Counseling Centers ◽  
Control Groups ◽  
Behavioral Counseling ◽  
Sexual Compatibility ◽  
Significant Difference ◽  
And Control

Abstract Objective: sexual desire is an integral part of an identity and character of a human being, that affect how to behave with spouse. This study aimed to study the effect of cognitive-behavioral counseling (CBT) on sexual compatibility of new married couples in Sanandaj City in 2018. Method: This was a randomized clinical trial study and participants were 80 new married couples whose information was recorded at the premarital counseling centers that were randomly divided into intervention and control groups. Intervention group received 8 weekly 120-minute sessions of group consultation with cognitive-behavioral approach. Data were collected before the intervention, after 8 weeks of counseling, and two months after the last counseling session using the National Sexual Compatibility Scale. Data were analyzed using chi-square inferential statistics and independent t-test or nonparametric Mann-Whitney test. analysis of covariance was used to control of potential confounders. Results: The mean values of sexual compatibility in two intervention and control groups before counseling were 94.20±3.30 and 93.41±6.84 respectively. These scores reached to 100.11±2.96 in the intervention group and 98.83±3.66 in the control group immediately after the intervention. Also two months after the end of counseling, this rate was 101.98±4.03 in the intervention group and 98.83±3.66 in the control group. The intra-group comparison of sexual adjustment scores before and after counseling and two months after the intervention, showed a statistically significant difference (P <0.001). The trend of changes in the control group was not significant (P >0.05). There was a significant difference between two groups in level of scores two months after the intervention (P <0.001). Conclusion: CBT was effective in improving the level of sexual compatibility between new married couples. It is recommended to use this method of counseling, along with other services provided at pre-marriage counseling centers, to continue and improve the quality of sex and vitality of couples.

scholarly journals EFEK SUPLEMENTASI MULTIVITAMIN MINERAL TERHADAP KADAR HEMOGLOBIN DAN HEMATOKRIT MAHASISWI TPB IPB

2013 ◽  
Vol 8 (1) ◽  
pp. 47
Author(s):  
Angga Hardiansyah ◽  
Rimbawan Rimbawan ◽  
Ikeu Ekayanti
Keyword(s):  
Intervention Group ◽  
Statistical Test ◽  
Female Students ◽  
Control Group ◽  
Blood Biomarkers ◽  
Control Groups ◽  
Double Blind ◽  
Mineral Supplementation ◽  
Quasi Experimental ◽  
And Control

The objective of this study was to analyze effect of multivitamin mineral supplementation to hemoglobin and hematocrit concentration of Bogor Agricultural University First Common Year female students. Design of this study was the quasi experimental, double blind, with number of subjects were 28 female students devided into two group. The intervention group consisted of 15 subjects, received supplement syrup 15 ml per day for eight weeks.The control group consisted of 13 subjects received placebo syrup. Data collected by interviewing subjects used questionnaire, physical examination, and blood biomarkers. The results of statistical test (paired sample t-test) showed that there were no significant increase in hemoglobin and hematocrit concentration respectively in both intervention and control groups (p&gt;0.05). However, on a subset of subjects anemia, the hemoglobin and hematocrit in the intervention group tended to increase larger than the control group.<br /><br />

scholarly journals Assessment of The Effect of Interprofessional Professionalism Training On The Surgical Team Members' Perception of The Ethical Climate

2021 ◽  
Author(s):  
Fatemeh Keshmiri ◽  
Azam Hoseinpour
Keyword(s):  
Operating Room ◽  
Interprofessional Education ◽  
Ethical Climate ◽  
Intervention Group ◽  
Educational Interventions ◽  
Control Group ◽  
Educational Systems ◽  
Control Groups ◽  
Significant Difference ◽  
And Control

Abstract BackgroundThe aim of present study was to assess the effect of interprofessional education concerning interprofessional professionalism on learners' perception of the ethical climate of the operating room.MethodThe present study is quasi-experimental design. Learners include surgical residents, operating room technicians, and anesthesia technicians (n=130) that distributed to intervention and control groups. The objectives of the intervention were the development of competencies of ethics and professionalism (including communication, altruism, respect, and excellence). The educational strategy was interprofessional education and the main method of training was scenario-based learning. Participants completed the Olson Moral Climate Questionnaire before and one month after the intervention. We used descriptive tests (mean, SD, percentage), student t-test and ANOVA to compare the scores of learners in the intervention and control groups.ResultsThe results of the study showed that the scores of the learners in the intervention group 4.05 (0.31) improved significantly compared to the control group 3.35 (0.37) (P = 0.0001). The scores of learners in the domain of ​​“managers” improved higher and the domain of ​​physicians improved lesser than other domains. There was no significant difference between the three groups of residents, operating room, and anesthesia technicians in terms of moral climate scores.ConclusionIn the present study showed the positive effect of interprofessional education interventions on individuals' perceptions of the operating room ethical climate. It is suggest that educational interventions be planned and implemented continuously in the educational systems and hospitals.

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