Life course and family history in dermatitis artefact: a comparative study

2011 ◽  
Vol 26 (S2) ◽  
pp. 1660-1660
Author(s):  
Y. El Kissi ◽  
J. Mannai ◽  
N. Kenani ◽  
R. Nouira ◽  
B. Ben Hadj Ali

IntroductionDermatitis artefact (DA) is a self-inflicted skin disease. The exploration of family history and life course of patients could help to better understand the pathogenesis of this disorder.ObjectiveTo compare family history and life course between patients with DA with patients with other chronic skin disease and siblings.Materials and methodsThirty female patients meeting DSM-IV criteria of DA were recruited in dermatology department of Farhat Hached hospital (Sousse, Tunisia).Controls consisted of 30 patients with chronic dermatitis, randomly selected and matched for age and disease duration. For each patient, one sister, the closest in age, was recruited to constitute the siblings group.ResultCompared with controls, DA patients had lower educational level (p < 10-3), less occupational activity (p = 0.002) and were more often single (p < 10-3). They reported more medical care or prolonged hospitalization in childhood (p = 0.013), more psychiatric disorders (p = 0.006) and more suicide attempts (p = 0.001).Compared with their sisters, patients with DA had fewer professional activity (p < 103), and were more often single (p < 10-3). They also had more medical history or prolonged hospitalizations during childhood (p = 0.006), more psychiatric disorders (p = 0.002) and more suicide attempts (p = 0.001).ConclusionCompared to their sisters and to patients with other chronic skin disease, DA patients were more often single, less often professionally active and had more medical care during childhood, psychiatric history and suicide attempts.

Author(s):  
S. Trachtenberg ◽  
P.M. Steinert ◽  
B.L. Trus ◽  
A.C. Steven

During terminal differentiation of vertebrate epidermis, certain specific keratin intermediate filament (KIF) proteins are produced. Keratinization of the epidermis involves cell death and disruption of the cytoplasm, leaving a network of KIF embedded in an amorphous matrix which forms the outer horny layer known as the stratum corneum. Eventually these cells are shed (desquamation). Normally, the processes of differentiation, keratinization, and desquamation are regulated in an orderly manner. In psoriasis, a chronic skin disease, a hyperkeratotic stratum corneum is produced, resulting in abnormal desquamation of unusually large scales. In this disease, the normal KIF proteins are diminished in amount or absent, and other proteins more typical of proliferative epidermal cells are present. There is also evidence of proteolytic degradation of the KIF.


2007 ◽  
Vol 0 (0) ◽  
pp. 071115063928006-??? ◽  
Author(s):  
A.W.M. Evers ◽  
P. Duller ◽  
P.C.M. van de Kerkhof ◽  
P.G.M. van der Valk ◽  
E.M.G.J. de Jong ◽  
...  

2019 ◽  
Vol 7 (3) ◽  
pp. e000691
Author(s):  
Martina Croci ◽  
Stefanie Klausmann ◽  
Jean-Michel Hatt ◽  
Sarah Schmitt ◽  
Monika Hilbe

Because of sudden death of several frogs following the renewal of a terrarium, two giant ditch frogs (Leptodactylus fallax) were submitted for post-mortem examination. The animals displayed extensive erythematous to ulcerative skin lesions as well as multiple granulomas in the liver, kidney and skeletal musculature. In skin lesions as well as in the brownish granulomas, pigmented fungal sclerotic bodies were found in addition to pigmented hyphal structures, though less common. The fungal pathogen, although not further classified in this study was identified as the etiological agent for chromoblastomycosis (synonym: chromomycosis), a leading cause of fatal systemic disease in poikilothermic animals. It is also a cause of chronic skin disease in human beings and therefore a potential zoonotic agent.


1999 ◽  
Vol 10 (12) ◽  
pp. 22-24
Author(s):  
Jean Watkins ◽  
Peter Goodwin ◽  
Denise Slade

2019 ◽  
Vol 12 (5) ◽  
pp. 271-275
Author(s):  
Apurva Mishra ◽  
Shanu Mishra

Rosacea is a common, chronic skin disease that affects the facial pilo-sebaceous glands. It is characterised by erythema, flushing and sometimes papules. It typically affects the convex surfaces of the face, most commonly the forehead, cheeks, chin and nose. Rosacea predominantly affects the Caucasian population, with prevalence being higher in northern Europe than southern Europe. It is three times more common in females and peaks between 30 and 60 years of age. Rosacea can usually be well managed with topical or oral treatments in primary care, although some forms of rosacea or treatment-resistant cases may need specialist input.


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