269 – Increase of beta-endorphin plasma level as a potential marker of positive response to treatment of depression

2013 ◽  
Vol 28 ◽  
pp. 1
Author(s):  
O. Kubryak ◽  
I. Emelyanova
Keyword(s):  
Plasma Level ◽  
Positive Response ◽  
Response To Treatment ◽  
Beta Endorphin ◽  
Potential Marker ◽  
Treatment Of Depression

scholarly journals Soluble CD147 (BSG) as a Prognostic Marker in Multiple Myeloma

2022 ◽  
Vol 44 (1) ◽  
pp. 350-359
Author(s):  
Piotr Łacina ◽  
Aleksandra Butrym ◽  
Diana Frontkiewicz ◽  
Grzegorz Mazur ◽  
Katarzyna Bogunia-Kubik
Keyword(s):  
Multiple Myeloma ◽  
Prognostic Marker ◽  
Positive Response ◽  
Advanced Disease ◽  
Response To Treatment ◽  
Soluble Form ◽  
Healthy Individuals ◽  
Potential Marker ◽  
Cancer Cell Survival ◽  
Membrane Bound

CD147 (basigin, BSG) is a membrane-bound glycoprotein involved in energy metabolism that plays a role in cancer cell survival. Its soluble form is a promising marker of some diseases, but it is otherwise poorly studied. CD147 is overexpressed in multiple myeloma (MM) and is known to affect MM progression, while its genetic variants are associated with MM survival. In the present study, we aimed to assess serum soluble CD147 (sCD147) expression as a potential marker in MM. We found that sCD147 level was higher in MM patients compared to healthy individuals. It was also higher in patients with more advanced disease (ISS III) compared to both patients with less advanced MM and healthy individuals, while its level was observed to drop after positive response to treatment. Patients with high sCD147 were characterized by worse overall survival. sCD147 level did not directly correlate with bone marrow CD147 mRNA expression. In conclusion, this study suggests that serum sCD147 may be a prognostic marker in MM.

Opinion paper: poor response to treatment of depression in people in high occupational levels

2018 ◽  
Vol 49 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Laura Mandelli ◽  
Alessandro Serretti ◽  
Stefano Porcelli ◽  
Daniel Souery ◽  
Julien Mendlewicz ◽  
...  
Keyword(s):  
Treatment Compliance ◽  
Poor Response ◽  
Recovery Process ◽  
Working Environment ◽  
Response To Treatment ◽  
Future Research ◽  
Residual Symptoms ◽  
Treatment Of Depression ◽  
High Cognitive Function ◽  
High Level

AbstractThe working environment may have a significant effect on response to treatment of depression and this issue has not yet been sufficiently addressed in the scientific literature. There is evidence showing that being engaged in high-level positions can be an obstacle to the success of treatment. This article discusses the few evidence in the literature and some of the possible mechanisms involved. Specific personality attributes and difficulties in adapting to depression may delay access to care and may also reduce treatment compliance. The presence of stress in jobs that require high cognitive function and lack of social support may be elements that hinder the recovery process. Residual symptoms that impact on cognitive functions may undermine adherence to treatment and adversely affect the response. The implications of these issues are potentially relevant for clinical practice in the treatment of depression and for future research.

High occupational level is associated with poor response to treatment of depression

2016 ◽  
Vol 26 ◽  
pp. S468
Author(s):  
L. Mandelli ◽  
A. Serretti ◽  
D. Souery ◽  
J. Mendlewicz ◽  
S. Kasper ◽  
...  
Keyword(s):  
Poor Response ◽  
Response To Treatment ◽  
Occupational Level ◽  
Treatment Of Depression

scholarly journals Unusual presentation of vitamin D3-dependent rickets type II in a kitten

2020 ◽  
Vol 6 (1) ◽  
pp. 205511692091027
Author(s):  
Florent Duplan ◽  
Christina Maunder
Keyword(s):  
Vitamin D ◽  
Positive Response ◽  
Abdominal Distension ◽  
Response To Treatment ◽  
Type I ◽  
Type Ii ◽  
Different Types ◽  
History Of ◽  
Radiographic Changes

Case summary A 15-week-old kitten presented with a 1-month history of intermittent generalised tremors and abdominal distension. Hypocalcaemia associated with increased 1,25-vitamin D3 was consistent with vitamin D3-dependent rickets type II. The bone appearance on CT scan was most consistent with the changes typically seen with nutritional secondary hyperparathyroidism and less typical of the changes seen with rickets. Our patient had a positive response to high vitamin D3 therapy as it remained normocalcaemic 16 months after diagnosis, supporting the diagnosis of rickets. Relevance and novel information This case report is an unusual and interesting presentation of rickets in a kitten. Despite the characteristic vitamin D3 disturbance for rickets type II, the atypical radiographic changes have not been previously reported. In the literature, a positive response to treatment is not commonly seen or follow-up is short. Our case responded well to treatment and was followed for 16 months from the time of diagnosis. This emphasises that the pathophysiology of the condition is not well understood, and that different types of vitamin D3-dependent rickets type II may exist. Although the genetic defects responsible for some cases of rickets type I have been identified, this has still not been determined for rickets type II.

When a Patient Presents With a Present: Quantitative and Qualitative Assessment of Gifts Given to Psychiatrists

2012 ◽  
Vol 13 (3) ◽  
pp. 209-228
Author(s):  
Richard M. Patel ◽  
Raquel Miller
Keyword(s):  
Positive Response ◽  
Low Cost ◽  
Qualitative Assessment ◽  
Response To Treatment ◽  
Mental Health Providers ◽  
Health Providers ◽  
Gift Giving ◽  
Important Data ◽  
Boundary Violation ◽  
Case Vignettes

Objective: This article reviews the issue of patients giving gifts to psychiatrists and mental health providers. Method: Anonymous survey of 100 academic psychiatrists measured prevalence of receiving gifts, type and estimated dollar value of gifts given, and psychiatrists’ reactions to gifts. Case vignettes illustrate clinical situations associated with gift giving and how failure to recognize motivation of gift giving may lead to situations requiring immediate intervention. Results: 71% of psychiatrists surveyed received (were offered & accepted) at least one gift in prior year (average 0.36 per month and 3.6 per year; $11.40 average [estimated] amount per gift). Group comparisons achieving at least a p < 0.05 significance: outpatient psychiatrists received gifts twice as often as inpatient, female and outpatient groups’ gifts were estimated as more expensive, a positive correlation was found between psychiatrists receiving gifts and psychiatrists giving a positive response to gifts, there was significantly more negative responses to high cost gifts (>$100) than to low cost (<$20), and outpatient psychiatrists reported interpreting gift’s meaning more often than inpatient. Conclusions: Psychiatrists are commonly offered and accept gifts from patients. Gifts communicate patient information and response to treatment. Although the act of gift giving sends important data to the receiving psychiatrist, including boundary violation issues, there are no agreed upon guidelines regarding how to respond. Future study should explore the meanings and appropriateness of a gift regarding type, cost, timing, frequency, intent, as well as how providers can respond to the gesture.

KLHL40-related nemaline myopathy with a sustained, positive response to treatment with acetylcholinesterase inhibitors

2016 ◽  
Vol 263 (3) ◽  
pp. 517-523 ◽  
Author(s):  
D. Natera-de Benito ◽  
A. Nascimento ◽  
A. Abicht ◽  
C. Ortez ◽  
C. Jou ◽  
...  
Keyword(s):  
Positive Response ◽  
Acetylcholinesterase Inhibitors ◽  
Nemaline Myopathy ◽  
Response To Treatment

Patient predictors of response to treatment of depression in Alzheimer's disease: the DIADS study

2004 ◽  
Vol 19 (2) ◽  
pp. 144-150 ◽  
Author(s):  
Martin Steinberg ◽  
Cynthia A. Munro ◽  
Quincy Samus ◽  
Peter V.Rabins ◽  
Jason Brandt ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Response To Treatment ◽  
Predictors Of Response ◽  
Treatment Of Depression

Lack of Beta-Endorphin Plasma Level Rise in Oxytocin-Induced Labor

1985 ◽  
Vol 19 (3) ◽  
pp. 130-134 ◽  
Author(s):  
Andrea R. Genazzani ◽  
Felice Petraglia ◽  
Fabio Facchinetti ◽  
Paolo A. Galli ◽  
Annibale Volpe
Keyword(s):  
Plasma Level ◽  
Induced Labor ◽  
Beta Endorphin

scholarly journals The Endogenous Opioid System in Schizophrenia and Treatment Resistant Schizophrenia: Increased Plasma Endomorphin 2, and κ and μ Opioid Receptors are Associated with Interleukin-6

2020 ◽  
Author(s):  
Shatha Rouf Moustafa ◽  
Khalid F. Al-Rawi ◽  
Arafat Hussein Al-Dujaili ◽  
Thitiporn Supasitthumrong ◽  
Hussein Kadhem Al-Hakeim ◽  
...  
Keyword(s):  
Negative Symptoms ◽  
Opioid System ◽  
Response To Treatment ◽  
Treatment Resistant ◽  
Endogenous Opioid System ◽  
Endogenous Opioid ◽  
Mu Opioid ◽  
Beta Endorphin ◽  
Neurocognitive Impairments ◽  
Thought Disorders

Background: Activation of the immune-inflammatory response system (IRS) and the compensatory immune-regulatory system (CIRS) play a key role in SCZ and treatment resistant SCZ. There are only few data on immune and endogenous opioid system (EOS) interactions in SCZ and treatment resistant SCZ.Aim of the study: We examined serum &beta;-endorphin, endomorphin-2 (EM2), mu-opioid (MOR) and kappa-opioid (KOR) receptors, and interleukin (IL)-6 and IL-10 in 60 non responders to treatment (NRTT), 55 partial RTT (PRTT) and 43 normal controls.Results: Serum EM2, KOR, MOR, IL-6 and IL-10 were significantly increased in SCZ as compared with controls. &beta;-endorphin, EM2, MOR and IL-6 were significantly higher in NRTT than in PRTT. There were significant correlations between IL-6, on the one hand, and &beta;-endorphin, EM2, KOR, and MOR, on the other, while IL-10 was significantly correlated with MOR only. A large part of the variance in negative symptoms, psychosis, hostility, excitation, mannerism, psychomotor retardation and formal thought disorders was explained by the combined effects of EM2 and MOR with or without IL-6 while increased KOR was significantly associated with all symptom dimensions. Increased MOR, KOR, EM2 and IL-6 were also associated with neurocognitive impairments including in episodic, semantic and working memory and executive functions.Conclusion: The EOS contributes to SCZ symptomatology, neurocognitive impairments and a non-response to treatment. In SCZ, EOS peptides/receptors may exert CIRS functions, whereas increased KOR levels may contribute to the pathophysiology of SCZ and EM2 and KOR to a non-response to treatment.

scholarly journals First Report of Psoriatic-Like Dermatitis and Arthritis in a 4-Year-Old Female Spayed Pug Mix

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Stephanie A. Regan ◽  
Rosanna Marsella ◽  
Ibrahim Ozmen
Keyword(s):  
Case Report ◽  
Positive Response ◽  
Treatment Options ◽  
Domestic Animals ◽  
Preliminary Evidence ◽  
Clobetasol Propionate ◽  
Response To Treatment ◽  
History Of ◽  
Control Pain ◽  
Tentative Diagnosis

Psoriasis manifests as chronic dermatitis and arthritis (PsA) in people. Psoriasis with concurrent PsA is characterized by erythematous, silvery, scaly plaques, especially on the extremities, and concurrent arthritis with enthesitis, tenosynovitis, and dactylitis. To date, no such disease has spontaneously occurred in domestic animals. This case report aims to describe the clinical, radiographic, and histologic appearance of a psoriasis-like dermatitis and psoriatic-like arthritis in a dog. A 4-year-old female spayed pug mix presented for the evaluation of chronic history of hyperkeratotic footpads and deforming arthritis. After ruling out other differential diagnoses and based on the similarity of clinical, radiographic, and histologic findings to human psoriasis and PsA, a tentative diagnosis of psoriasis-like disease was made. Treatment was begun to control pain (tramadol, gabapentin, and carprofen) and psoriatic dermatitis (clobetasol propionate 0.05%, calcipotriene 0.005%, and urea 40% ointment twice daily). Dramatic positive response to treatment was achieved confirming the tentative diagnosis. This case may provide preliminary evidence for the existence of a psoriasis-like condition in dogs and may elucidate treatment options in otherwise refractory cases of chronic dermatitis and polyarthropathy in dogs.

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