The Mthfr 677t Allele May Influence the Severity and Biochemical Risk Factors of Alzheimer'Sdisease in an Egyptian Population

Background: Even though extensive studies on the prevalence of periodontal diseases in various populations worldwide have been carried out, data for the Egyptian population is limited. The present study was carried out to evaluate the occurrence and the severity of periodontal disease and its correlation with different risk factors. Methods: Periodontal examination was performed on 343 adults attending the outpatient clinics of the Faculty of Dentistry, Cairo University, as well as three private clinics. Socio-demographic data, brushing frequency, body mass index (BMI) and dietary habits were recorded using a questionnaire. Results: It was found that 58.9% of participants had calculus deposits. The occurrence of periodontitis was 89.8%, where 70.8% of participants had stage I and 15.2% had stage II, while only 4.4% and 2.05% suffered from stage III and stage IV, respectively. Calculus was positively correlated with age, grains, and sugar in drinks and negatively correlated with socioeconomic status, education level, brushing frequency and milk. Calculus was not correlated with gender and BMI. Periodontitis was positively correlated with age, carbohydrates other than bread, grains, and crackers, as well as caffeinated drinks, while negatively correlated with gender, socioeconomic status, brushing frequency. Periodontitis was not correlated with BMI or education level. Conclusion: The present study clarifies that age, brushing frequency, carbohydrates and caffeinated drinks consumption are significant factors influencing the occurrence and the severity of periodontal diseases.

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The Missing Piece, The Screening for Diabetes ,Obesity and Hypertension Risk Factors Associated with Hepatitis C In Egyptian Population in a Community Pharmacy Setting.

10.22541/au.159769430.05218135 ◽

2020 ◽

Author(s):

amira kassem ◽

Alaa mousa ◽

amira harun ◽

Heba Alhusseini ◽

salma Khaled ◽

...

Keyword(s):

Risk Factors ◽

Hepatitis C ◽

Community Pharmacy ◽

Factors Associated ◽

Hypertension Risk ◽

Egyptian Population ◽

Pharmacy Setting

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Prevalence, risk factors, and morbidity of eyelid laxity in elderly Egyptian population

Delta Journal of Ophthalmology ◽

10.4103/djo.djo_1_20 ◽

2020 ◽

Vol 21 (2) ◽

pp. 127

Author(s):

ShymaaI Saad ◽

MohamedA Ragab ◽

IhabM Osman

Keyword(s):

Risk Factors ◽

Egyptian Population

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Risk factors for occurrence of acute stroke that required critical care unit admission in Egyptian population (RASEP study)

Research and Opinion in Anesthesia and Intensive Care ◽

10.4103/roaic.roaic_29_21 ◽

2021 ◽

Vol 8 (4) ◽

pp. 204

Author(s):

Sherif Abdelmonem ◽

TayseerM Zaytoun ◽

RehamT Elsayed

Keyword(s):

Risk Factors ◽

Critical Care ◽

Acute Stroke ◽

Critical Care Unit ◽

Egyptian Population

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Prevalence of periodontal diseases and its correlation with different risk factors among an adult Egyptian population: a cross-sectional study

F1000Research ◽

10.12688/f1000research.20310.1 ◽

2019 ◽

Vol 8 ◽

pp. 1740 ◽

Cited By ~ 1

Author(s):

Marwa M.S. Abbass ◽

Dina Rady ◽

Israa Ahmed Radwan ◽

Sara El Moshy ◽

Nermeen AbuBakr ◽

...

Keyword(s):

Risk Factors ◽

Socioeconomic Status ◽

Dietary Habits ◽

Periodontal Diseases ◽

Demographic Data ◽

Stage Iv ◽

Education Level ◽

Or Education ◽

Cross Sectional ◽

Egyptian Population

Background: Even though extensive studies on the prevalence of periodontal diseases in various populations worldwide have been carried out, data for the Egyptian population is limited. The present study was carried out to evaluate the prevalence and the severity of periodontal disease and its correlation with different risk factors. Methods: Periodontal examination was performed on 343 adults attending the outpatient clinics of the Faculty of Dentistry, Cairo University, as well as three private clinics. Socio-demographic data, brushing frequency, body mass index (BMI) and dietary habits were recorded using a questionnaire. Results: It was found that 58.9% of participants had calculus deposits. The prevalence of periodontitis was 89.8%, where 70.8% of participants had stage I and 15.2% had stage II, while only 4.4% and 2.05% suffered from stage III and stage IV, respectively. Calculus was positively correlated with age, grains, and sugar in drinks and negatively correlated with socioeconomic status, education level, brushing frequency and milk. Calculus was not correlated with gender and BMI. Periodontitis was positively correlated with age, carbohydrates other than bread, grains, crackers, and caffeinated drinks, while negatively correlated with gender, socioeconomic status, brushing frequency. Periodontitis was not correlated with BMI or education level. Conclusion: The present study clarifies that age, brushing frequency, carbohydrates and caffeinated drinks consumption are significant factors influencing the prevalence and the severity of periodontal diseases.

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miR-155 T/A (rs767649) and miR-146a A/G (rs57095329) single nucleotide polymorphisms as risk factors for chronic hepatitis B virus infection among Egyptian patients

PLoS ONE ◽

10.1371/journal.pone.0256724 ◽

2021 ◽

Vol 16 (8) ◽

pp. e0256724

Author(s):

Enas M. Hefzy ◽

Noha A. Hassuna ◽

Olfat G. Shaker ◽

Mohamed Masoud ◽

Tebyan A. Abelhameed ◽

...

Keyword(s):

Risk Factors ◽

Hepatitis B ◽

Disease Risk ◽

In Silico Analysis ◽

Nucleotide Polymorphisms ◽

Egyptian Population ◽

Increased Risk ◽

Chronic Hepatitis B Virus ◽

Significant Difference ◽

Potential Risk Factors

Genetic variants in microRNAs (miRNAs) can alter the miRNAs expression and/or function, accordingly, affecting the related biological pathways and disease risk. Dysregulation of miR-155 and miR-146a expression levels has been well-described in viral hepatitis B (HBV). In the current study, we aimed to assess rs767649 T/A and rs57095329 A/G polymorphisms in miR-155, and miR-146a genes, respectively, as risk factors for Chronic HBV (CHBV) in the Egyptian population. Also, we aimed to do in silico analysis to investigate the molecules that primarily target these miRNAs. One hundred patients diagnosed as CHBV and one hundred age and sex-matched controls with evidence of past HBV infection were genotyped for miR-155 (rs767649) and miR-146a (rs57095329) using real-time polymerase chain reaction. The rs767649 AT and AA genotypes in CHBV patients confer four folds and ten folds risk respectively, as compared to control subjects [(AOR = 4.245 (95%CI 2.009–8.970), p<0.0001) and AOR = 10.583 (95%CI 4.012–27.919), p<0.0001, respectively)]. The rs767649 A allele was associated with an increased risk of developing CHBV (AOR = 2.777 (95%CI 1.847–4.175), p<0.0001). There was a significant difference in the frequency of rs57095329 AG and GG genotypes in CHBV patients compared to controls. AG and GG genotypes showed an increase in the risk of developing CHBV by about three and six folds respectively [AOR = 2.610 (95%CI 1.362–5.000), p = 0.004] and [AOR = 5.604 (95%CI 2.157–14.563), p<0.0001].We concluded that rs57095329 and rs767649 SNPs can act as potential risk factors for the development of CHBV in the Egyptian population.

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Awareness and risk factors of autism spectrum disorder in an Egyptian population

Research in Autism Spectrum Disorders ◽

10.1016/j.rasd.2021.101781 ◽

2021 ◽

Vol 84 ◽

pp. 101781

Author(s):

Nagwa Abdel Meguid ◽

Neveen Hassan Nashaat ◽

Amal Elsaeid ◽

Massimiliano Peana ◽

Ahmed Elnahry ◽

...

Keyword(s):

Risk Factors ◽

Autism Spectrum Disorder ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Egyptian Population

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Is there a correlation between -174(G/C) polymorphism of IL-6 gene and the incidence of acute myocardial infarction?

Journal of Genetic Engineering and Biotechnology ◽

10.1186/s43141-021-00243-x ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Ingy M. Hashad ◽

Habiba Nosseir ◽

Gamal M. Shaban ◽

Mohamed F. Abdel Rahman ◽

Mohamed Z. Gad

Keyword(s):

Risk Factors ◽

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Promoter Sequence ◽

Serum Levels ◽

Inflammatory Disorder ◽

Genotype Distribution ◽

Egyptian Population ◽

Control Subjects ◽

Pcr Rflp

Abstract Background Cardiovascular disease (CVD) remains the major cause of death worldwide. Most CVD can be prevented by addressing risk factors. Acute myocardial infarction (AMI) is an inflammatory disorder characterized by changes in several cytokines including the interleukins (ILs). Studies are running to evaluate the genetic variation in the inflammatory system and their influence on the risk factors for CVD aiming for future prevention of this global disease. The aim of the current study was too investigate the association of -174 (G/C) IL-6 polymorphism with the incidence of AMI in a representative sector of the Egyptian population and to examine the contribution of IL-6, as a biomarker, in the pathogenesis of AMI. Genotyping of -174 (G/C) IL-6 polymorphism was done by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) while IL-6 levels were assayed by ELISA. Results The genotype distribution of -174 (G/C) IL-6 gene was not significantly different between the control subjects (GG 81.7%, GC 16.3%, CC 1.9%) and the AMI patients (GG 79%, GC 19%, CC 2%).The serum levels of IL-6 were significantly elevated in the AMI patients in comparison to the control subjects (P < 0.0001). Conclusions There is no significant association of -174(G/C) polymorphism in the promoter sequence of IL-6 and the incidence of AMI in the examined sample of Egyptian population. Elevated levels of serum IL-6 confirmed the relationship between inflammation and the incidence of AMI.

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