P.4.b.009 Obsessive–compulsive symptoms in a population-based birth cohort, and their association with level of functioning

2014 ◽  
Vol 24 ◽  
pp. S592
Author(s):  
N. Werbeloff ◽  
B.P. Dohrenwend ◽  
I. Levav ◽  
M. Weiser
Keyword(s):  
Birth Cohort ◽  
Population Based ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Level Of Functioning

scholarly journals Prader–Willi syndrome, compulsive and ritualistic behaviours: the first population-based survey

2002 ◽  
Vol 180 (4) ◽  
pp. 358-362 ◽  
Author(s):  
D. J. Clarke ◽  
H. Boer ◽  
J. Whittington ◽  
A. Holland ◽  
J. Butler ◽  
...  
Keyword(s):  
Intellectual Disability ◽  
Rating Scales ◽  
Structured Interview ◽  
Population Based ◽  
Control Group ◽  
Prader Willi Syndrome ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
Population Based Survey

BackgroundObsessive–compulsive disorder has been reported in association with Prader–Willi syndrome.AimsTo report the nature and prevalence of compulsive and similar symptoms associated with Prader–Willi syndrome in a population ascertained as completely as possible.MethodAttempted complete ascertainment of people with Prader– Willi syndrome in eight English counties. Administration of standardised rating scales and a structured interview. Comparison with people with learning disability and high body mass indices.ResultsPrader–Willi syndrome was associated with high rates of ritualistic behaviours, such as the need to ask or to tell something, insistence on routines, hoarding and ordering objects and repetitive actions and speech, compared with the control group, and was negatively correlated with IQ and socialisation age. Typical obsessive–compulsive symptoms, such as checking, counting and cleaning compulsions or obsessional thoughts, were not found.ConclusionsRitualistic and compulsive behaviours occur more frequently in association with Prader–Willi syndrome than among people with intellectual disability and significant obesity.

scholarly journals Shared genetic etiology between obsessive-compulsive disorder, obsessive-compulsive symptoms in the population, and insulin signaling

2019 ◽  
Author(s):  
Janita Bralten ◽  
Joanna Widomska ◽  
Ward De Witte ◽  
Dongmei Yu ◽  
Carol A. Mathews ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Obsessive Compulsive Disorder ◽  
Insulin Signaling ◽  
Population Based ◽  
Obsessive Compulsive ◽  
Genetic Etiology ◽  
Obsessive Compulsive Symptoms ◽  
Gene Set ◽  
Compulsive Disorder ◽  
Shared Genetic

AbstractObjectiveObsessive-compulsive symptoms (OCS) in the population have been linked to obsessive-compulsive disorder (OCD) in genetic and epidemiological studies. Insulin signaling has been implicated in OCD. We extend previous work by assessing genetic overlap between OCD, population-based OCS, and central nervous system (CNS) and peripheral insulin signaling.MethodsWe conducted genome-wide association studies (GWASs) in the population-based Philadelphia Neurodevelopmental Cohort (PNC, 650 children and adolescents) of the total OCS score and six OCS factors from an exploratory factor analysis of 22 questions. Subsequently, we performed polygenic risk score (PRS) analysis to assess shared genetic etiologies between clinical OCD (using GWAS data from the Psychiatric Genomics Consortium), the total OCS score and OCS factors. We then performed gene-set analyses with a set of OCD-linked genes centered around CNS insulin-regulated synaptic function and PRS analyses for five peripheral insulin signaling-related traits. For validation purposes, we explored data from the independent Spit for Science population cohort (5047 children and adolescents).ResultsIn the PNC, we found a shared genetic etiology between OCD and ‘impairment’, ‘contamination/cleaning’ and ‘guilty taboo thoughts’. In the Spit for Science cohort, we were able to validate the finding for ‘contamination/cleaning’, and additionally observed genetic sharing between OCD and ‘symmetry/counting/ordering’. The CNS insulin-linked gene-set associated with ‘symmetry/counting/ordering’. We also identified genetic sharing between peripheral insulin signaling-related traits (type 2 diabetes and the blood levels of HbA1C, fasting insulin and 2 hour glucose) and OCD as well as certain OCS.ConclusionsOCD, OCS in the population and insulin-related traits share genetic risk factors, indicating a common etiological mechanism underlying somatic and psychiatric disorders.

scholarly journals Genetic Factors Underlie Stability of Obsessive–Compulsive Symptoms

2009 ◽  
Vol 12 (5) ◽  
pp. 411-419 ◽  
Author(s):  
Daniël S. van Grootheest ◽  
Daniëlle Cath ◽  
Jouke Jan Hottenga ◽  
Aartjan T. Beekman ◽  
Dorret I. Boomsma
Keyword(s):  
Genetic Factors ◽  
Adult Population ◽  
Genetic Correlations ◽  
Population Based ◽  
Self Report ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Genetic And Environmental Factors ◽  
The Stability ◽  
Time Point

AbstractThe contribution of genetic and environmental factors to the stability of obsessive–compulsive (OC) symptoms has not yet been established in adult population based samples. We obtained the Young Adult Self Report Obsessive–Compulsive Subscale in mono- and dizygotic twins from the population-based Netherlands Twin Register in 1991, 1995 and 1997 and the Padua Inventory Revised Abbreviated in 2002. Stability of OC symptoms was analyzed as a function of genetic and environmental components. Heritability of OC behavior was around 40% at each time-point, independent of the instrument used. OC behavior was moderately stable with correlations ranging between r = .2 (for 11-year intervals), .4 (for 4–5 year intervals) and .6 (for 2 year intervals). Genetic correlations across time were higher, varying between .4 and .9, indicating that the stability of OC symptoms is mainly due to stable genetic factors. This study showed a moderate heritability and stability for OC behavior in adults. Genetic stability across time is high.

scholarly journals Obsessive-compulsive symptoms and obsessive-compulsive disorder in adolescents: a population-based study

2013 ◽  
Vol 36 (2) ◽  
pp. 111-118 ◽  
Author(s):  
Analise de Souza Vivan ◽  
Lidiane Rodrigues ◽  
Guilherme Wendt ◽  
Mônica Giaretton Bicca ◽  
Daniela Tusi Braga ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Population Based ◽  
Obsessive Compulsive ◽  
Population Based Study ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder

The prediction of length of major depressive episodes: results from an epidemiological sample of female twins

1997 ◽  
Vol 27 (1) ◽  
pp. 107-117 ◽  
Author(s):  
K. S. KENDLER ◽  
E. E. WALTERS ◽  
R. C. KESSLER
Keyword(s):  
Genetic Risk ◽  
Cox Model ◽  
Population Based ◽  
Obsessive Compulsive ◽  
Course Of Illness ◽  
Obsessive Compulsive Symptoms ◽  
Financial Difficulties ◽  
Major Depressive Episodes ◽  
Depressive Episodes ◽  
Severe Life Events

In order to examine factors that influence the time to recovery (TTR) from depressive episodes in women, we examined members of 1030 female–female twin pairs of known zygosity, ascertained from a population-based twin registry. We predicted, in a Cox model, TTR in 235 women with an onset of an episode of major depression (MD) in the last year meeting DSM-III-R criteria. The median and mean TTR for episodes of MD was 42 and 82 days, respectively ; only 2·2% of women had not recovered by 1 year. Four variables predicted TTR: financial difficulties, obsessive–compulsive symptoms, severe life events (SLEs), and genetic risk. Dividing all depressive episodes meeting symptomatic DSM-III-R criteria into early (5–28 days) and late (>28 days) phases, significant predictors of TTR early in the course of illness (income, parental protectiveness and separation, personality, lifetime traumas and SLEs) differed from those that predicted TTR later in the depressive episode (health, social support, obsessive–compulsive symptoms, SLEs and genetic risk). Including cases with chronic MD increased the strength of personality, financial problems and genetic risk as predictors of slow TTR. These exploratory analyses suggest that TTR from MD in women is influenced by multiple environmental, temperamental and genetic factors. Predictors of TTR early and later in the course of MD may differ qualitatively, suggesting different processes in recovery from brief versus prolonged depressions.

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