Prader–Willi syndrome, compulsive and ritualistic behaviours: the first population-based survey

BackgroundObsessive–compulsive disorder has been reported in association with Prader–Willi syndrome.AimsTo report the nature and prevalence of compulsive and similar symptoms associated with Prader–Willi syndrome in a population ascertained as completely as possible.MethodAttempted complete ascertainment of people with Prader– Willi syndrome in eight English counties. Administration of standardised rating scales and a structured interview. Comparison with people with learning disability and high body mass indices.ResultsPrader–Willi syndrome was associated with high rates of ritualistic behaviours, such as the need to ask or to tell something, insistence on routines, hoarding and ordering objects and repetitive actions and speech, compared with the control group, and was negatively correlated with IQ and socialisation age. Typical obsessive–compulsive symptoms, such as checking, counting and cleaning compulsions or obsessional thoughts, were not found.ConclusionsRitualistic and compulsive behaviours occur more frequently in association with Prader–Willi syndrome than among people with intellectual disability and significant obesity.

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Severity of Obsessive-Compulsive Symptoms is Related to Self-Directedness Character Trait in Obsessive-Compulsive Disorder

CNS Spectrums ◽

10.1017/s1092852900002789 ◽

2004 ◽

Vol 9 (8) ◽

pp. 607-612 ◽

Cited By ~ 17

Author(s):

Carlos Cruz-Fuentes ◽

Claudia Blas ◽

Laura Gonzalez ◽

Beatriz Camarena ◽

Humberto Nicolini

Keyword(s):

Obsessive Compulsive Disorder ◽

Rating Scales ◽

Character Trait ◽

Depression And Anxiety ◽

Temperament And Character Inventory ◽

Obsessive Compulsive ◽

Obsessive Compulsive Symptoms ◽

Compulsive Disorder ◽

Behavioral Features ◽

Character Inventory

ABSTRACT:Objective:The present study examined the psychobiological Temperament and Character model of personality on obsessive-compulsive disorder (OCD) patients, as well as the relation of temperament and/or character dimensions on the severity of obsessive-compubive symptoms.Methods:Fifty-four subjects diagnosed with OCD, were assessed with the Temperament and Character Inventory, the Yale-Brown Obsessive-Compulsive scale and the Hamilton Rating Scales for depression and anxiety.Results:Compared with controls, OCD subjects displayed increased harm avoidance and lower self-directedness and cooperativeness. Low self-directedness and high Hamilton depression scores were associated with increased severity of obsessive-compulsive symptoms.Conclusions:The Temperament and Character profile of OCD patients characterized in the present stud personality model and can be linked to some of their behavioral features. Furthermore, our data provides support of the influence that some personality traits may have on the severity of OCD symptoms.

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Severe obsessive-compulsive disorder (OCD): socio-demographic and clinical features

Clinical Management Issues ◽

10.7175/cmi.v7i2.646 ◽

2013 ◽

Vol 7 (2) ◽

pp. 53-61 ◽

Cited By ~ 1

Author(s):

Sylvia Rigardetto ◽

Andrea Aguglia ◽

Gabriele Di Salvo ◽

Umberto Albert ◽

Filippo Bogetto ◽

...

Keyword(s):

Mood Disorders ◽

Clinical Features ◽

Rating Scales ◽

Age Of Onset ◽

Total Sample ◽

Structured Interview ◽

Main Diagnosis ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Cluster A

Aim: the aim of the study is to evaluate the socio-demographic and clinical features with prognostic value in predicting evolution in severe OCD.Materials and methods: patients with a main diagnosis of OCD were recruited according to DSM-IV criteria. Socio-demographic and clinical features were assessed by mean of a semi-structured interview and clinical rating scales (Y-BOCS, HAM-A, HAM-D and SCID-II). Two subgroups were compared according to the severity of symptoms (severe vs mild-moderate).Results: the total sample was made up of 450 OCD subjects aged 34.5±12.1, with a mean age of onset 22.3±9.1; 215 subjects (47.8%) were females. Patients with severe OCD (Y-BOCS ≥ 32) showed a more insidious onset and a more chronic course compared to patients with mild-moderate symptoms. Other predictors of increased OCD severity were washing and hoarding compulsions. Lastly, the severity of the obsessive-compulsive condition was higher when it was associated either with mood disorders or with Axis II disorders (particularly Cluster A).Discussion: our study shows a correlation between severe OCD and severity predictors such as functional impairment and mood disorders. Furthermore washing and hoarding symptoms, lifetime comorbity with mood disorders and Cluster A personality disorders seem to predict OCD severity.

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Shared genetic etiology between obsessive-compulsive disorder, obsessive-compulsive symptoms in the population, and insulin signaling

10.1101/608034 ◽

2019 ◽

Author(s):

Janita Bralten ◽

Joanna Widomska ◽

Ward De Witte ◽

Dongmei Yu ◽

Carol A. Mathews ◽

...

Keyword(s):

Children And Adolescents ◽

Obsessive Compulsive Disorder ◽

Insulin Signaling ◽

Population Based ◽

Obsessive Compulsive ◽

Genetic Etiology ◽

Obsessive Compulsive Symptoms ◽

Gene Set ◽

Compulsive Disorder ◽

Shared Genetic

AbstractObjectiveObsessive-compulsive symptoms (OCS) in the population have been linked to obsessive-compulsive disorder (OCD) in genetic and epidemiological studies. Insulin signaling has been implicated in OCD. We extend previous work by assessing genetic overlap between OCD, population-based OCS, and central nervous system (CNS) and peripheral insulin signaling.MethodsWe conducted genome-wide association studies (GWASs) in the population-based Philadelphia Neurodevelopmental Cohort (PNC, 650 children and adolescents) of the total OCS score and six OCS factors from an exploratory factor analysis of 22 questions. Subsequently, we performed polygenic risk score (PRS) analysis to assess shared genetic etiologies between clinical OCD (using GWAS data from the Psychiatric Genomics Consortium), the total OCS score and OCS factors. We then performed gene-set analyses with a set of OCD-linked genes centered around CNS insulin-regulated synaptic function and PRS analyses for five peripheral insulin signaling-related traits. For validation purposes, we explored data from the independent Spit for Science population cohort (5047 children and adolescents).ResultsIn the PNC, we found a shared genetic etiology between OCD and ‘impairment’, ‘contamination/cleaning’ and ‘guilty taboo thoughts’. In the Spit for Science cohort, we were able to validate the finding for ‘contamination/cleaning’, and additionally observed genetic sharing between OCD and ‘symmetry/counting/ordering’. The CNS insulin-linked gene-set associated with ‘symmetry/counting/ordering’. We also identified genetic sharing between peripheral insulin signaling-related traits (type 2 diabetes and the blood levels of HbA1C, fasting insulin and 2 hour glucose) and OCD as well as certain OCS.ConclusionsOCD, OCS in the population and insulin-related traits share genetic risk factors, indicating a common etiological mechanism underlying somatic and psychiatric disorders.

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Magical Thinking in Obsessive-Compulsive Disorder, Panic Disorder and the General Community

Behavioural and Cognitive Psychotherapy ◽

10.1017/s1352465806002864 ◽

2006 ◽

Vol 34 (3) ◽

pp. 351-357 ◽

Cited By ~ 21

Author(s):

Danielle A. Einstein ◽

Ross G. Menzies

Keyword(s):

Panic Disorder ◽

Obsessive Compulsive Disorder ◽

Normal Subjects ◽

Control Group ◽

Short Version ◽

Magical Thinking ◽

Obsessive Compulsive ◽

Magical Ideation ◽

Obsessive Compulsive Symptoms ◽

Compulsive Disorder

Magical Ideation was examined in 71 individuals across four groups matched, where possible, for gender and age. These groups were: (1) Obsessive Compulsive Disorder (OCD) patients with cleaning compulsions (n = 11); (2) OCD patients with checking compulsions (n = 20); (3) panic disorder patients with minimal obsessive compulsive symptoms (n = 19); (4) a “normal” control group with minimal obsessive compulsive symptoms (n = 21). The Magical Ideation Scale (MI, Eckblad and Chapman, 1983), the Obsessive Compulsive Inventory- Short Version (OCI-SV; Foa et al., 2002) and the Maudsley Obsessional-Compulsive Inventory (MOCI, Hodgson and Rachman, 1977) were administered to all participants. A one-way Anova was conducted with four planned contrasts. As expected, the OCD groups obtained magical ideation scores higher than the normal subjects. This suggests that OCD patients engage in more magical thinking tendencies than non-anxious controls. Similarly, OCD participants obtained a mean magical ideation score significantly higher than the panic disorder group, suggesting that obsessional compulsive patients are more likely to exhibit magical thinking than individuals with panic disorder. Of note, panic disorder and control group means on MI did not differ significantly. Finally, individuals with obsessive cleaning compulsions displayed higher levels of magical thinking compared to individuals with obsessive checking compulsions, despite no difference in severity of their obsessive compulsive symptoms. This observation was counter to previous findings (Einstein and Menzies, 2004a; Einstein and Menzies, 2004b).

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Anxiety Disorders in Adults with Autism Spectrum Disorder: A Population-Based Study

Journal of Autism and Developmental Disorders ◽

10.1007/s10803-019-04234-3 ◽

2019 ◽

Vol 50 (1) ◽

pp. 308-318 ◽

Cited By ~ 7

Author(s):

Victoria Nimmo-Smith ◽

Hein Heuvelman ◽

Christina Dalman ◽

Michael Lundberg ◽

Selma Idring ◽

...

Keyword(s):

Intellectual Disability ◽

Anxiety Disorders ◽

Population Based ◽

Autism Spectrum ◽

Obsessive Compulsive ◽

Adults With Autism ◽

Compulsive Disorder ◽

Autistic People ◽

Almost All ◽

Adults With Asd

Abstract Anxiety is common in children with ASD; however, the burden of specific anxiety disorders for adults with ASD is under-researched. Using the Stockholm Youth Cohort, we compared anxiety disorder diagnoses among autistic adults (n = 4049), with or without intellectual disability, and population controls (n = 217,645). We conducted additional sibling analyses. Anxiety disorders were diagnosed in 20.1% of adults with ASD compared with 8.7% of controls (RR = 2.62 [95% CI 2.47–2.79]), with greatest risk for autistic people without intellectual disability. Rates of almost all individual anxiety disorders were raised, notably obsessive–compulsive disorder and phobic anxiety disorders. Anxiety disorders were more common in full siblings and half-siblings of people with ASD. The implications of this are explored.

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Relationship Between Cognitive Fusion, Experiential Avoidance, and Obsessive–Compulsive Symptoms in Patients With Obsessive–Compulsive Disorder

Frontiers in Psychology ◽

10.3389/fpsyg.2021.655154 ◽

2021 ◽

Vol 12 ◽

Author(s):

Ai Xiong ◽

Xiong Lai ◽

Siliang Wu ◽

Xin Yuan ◽

Jun Tang ◽

...

Keyword(s):

Obsessive Compulsive Disorder ◽

Experiential Avoidance ◽

Depression Scale ◽

Control Group ◽

Hamilton Depression Scale ◽

Cognitive Fusion ◽

Obsessive Compulsive ◽

Obsessive Compulsive Symptoms ◽

Compulsive Disorder ◽

Acceptance And Action Questionnaire

Objective: This study aimed to explore the relationship among cognitive fusion, experiential avoidance, and obsessive–compulsive symptoms in patients with obsessive–compulsive disorder (OCD).Methods: A total of 118 outpatient and inpatient patients with OCD and 109 healthy participants, gender- and age-matched, were selected using cognitive fusion questionnaire (CFQ), acceptance and action questionnaire−2nd edition (AAQ-II), Yale–Brown scale for obsessive–compulsive symptoms, Hamilton anxiety scale, and Hamilton depression scale for questionnaire testing and data analysis.Results: The levels of cognitive fusion and experiential avoidance in the OCD group were significantly higher than those in the healthy control group (P < 0.05). Regression analysis results showed that, in predicting the total score of obsessive–compulsive symptoms, AAQ-II (β = 0.233, P < 0.05) and CFQ (β = 0.262, P < 0.01) entered the equation, which explained 17.1% variance. In predicting anxiety, only AAQ-II (β = 0.222, P < 0.05) entered the equation, which explained 13% variance. In the prediction of depression, AAQ-II (β = 0.412, P < 0.001) entered the equation, which explained 17.7% variance.Conclusion: Cognitive fusion and experiential avoidance may be important factors for the maintenance of OCD, and experiential avoidance can positively predict the anxiety and depression of OCD patients.

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Obsessive-compulsive symptoms and obsessive-compulsive disorder in adolescents: a population-based study

Brazilian Journal of Psychiatry ◽

10.1590/1516-4446-2013-1113 ◽

2013 ◽

Vol 36 (2) ◽

pp. 111-118 ◽

Cited By ~ 21

Author(s):

Analise de Souza Vivan ◽

Lidiane Rodrigues ◽

Guilherme Wendt ◽

Mônica Giaretton Bicca ◽

Daniela Tusi Braga ◽

...

Keyword(s):

Obsessive Compulsive Disorder ◽

Population Based ◽

Obsessive Compulsive ◽

Population Based Study ◽

Obsessive Compulsive Symptoms ◽

Compulsive Disorder

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Structured Interview for Hoarding Disorder (SIHD)

European Journal of Psychological Assessment ◽

10.1027/1015-5759/a000433 ◽

2019 ◽

Vol 35 (4) ◽

pp. 512-520

Author(s):

Caterina Novara ◽

Paolo Cavedini ◽

Stella Dorz ◽

Susanna Pardini ◽

Claudio Sica

Keyword(s):

Convergent Validity ◽

Structured Interview ◽

Diagnostic Process ◽

Schizophrenia Spectrum Disorders ◽

Clinical Environment ◽

Obsessive Compulsive ◽

Rater Reliability ◽

Hoarding Disorder ◽

Compulsive Disorder ◽

Schizophrenia Spectrum

Abstract. The Structured Interview for Hoarding Disorder (SIHD) is a semi-structured interview designed to assist clinicians in diagnosing a hoarding disorder (HD). This study aimed to validate the Italian version of the SIHD. For this purpose, its inter-rater reliability has been analyzed as well as its ability to differentiate HD from other disorders often comorbid. The sample was composed of 74 inpatients who had been diagnosed within their clinical environment: 9 with HD, 11 with obsessive-compulsive disorder (OCD) and HD, 22 with OCD, 19 with major depressive disorder (MDD), and 13 with schizophrenia spectrum disorders (SSD). The results obtained indicated “substantial” or “perfect” inter-rater reliability for all the core HD criteria, HD diagnosis, and specifiers. The SIHD differentiated between subjects suffering from and not suffering from a HD. Finally, the results indicated “good” convergent validity and high scores were shown in terms of both sensitivity and specificity for HD diagnosis. Altogether, the SIHD represents a useful instrument for evaluating the presence of HD and is a helpful tool for the clinician during the diagnostic process.

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Reducing the Social Stigma Associated with Obsessive Compulsive Disorder: A Controlled Trial of an Intervention Program in a Turkish Community Sample

Journal of Evidence-Based Psychotherapies ◽

10.24193/jebp.2020.2.14 ◽

2020 ◽

Vol 20 (2) ◽

pp. 101-120

Author(s):

Ayça Aktaç Gürbüz ◽

Orçun YORULMAZ ◽

Gülşah DURNA

Keyword(s):

Obsessive Compulsive Disorder ◽

Intervention Program ◽

Controlled Trial ◽

Community Sample ◽

Case Vignette ◽

Control Group ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Significant Difference ◽

The Impact

Scientific research into the reduction of stigmatization, particularly related to specific problems such as Obsessive-Compulsive Disorder (OCD), is scarce. In the present study, we examine the impact of a video-based antistigma intervention program for OCD in a pretest-posttest control group research. After being randomly assigned to either an intervention (n= 101) or control group (n= 96), the participants reported their attitudes on a hypothetical case vignette before and after OCD vs. Multiple Sclerosis (MS) videos, and again six months later as a follow up assessment. The mixed design analyses for the group comparisons indicated that although there was no significant difference in the measures of the control group, the participants watching the anti-stigma OCD video, in which the focus was psychoeducation and interaction strategies, reported significantly lower scores on social distances and negative beliefs for the case vignettes they read, and this difference was maintained six months later. Then, the present results indicate the effectiveness of our anti-stigma intervention program for OCD. Interventions to reduce stigmatization can also be viewed as effective tools for changing the attitudes of people toward OCD, although further research and applications are needed related to specific disorders if a longlasting impact is to be achieved.

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Elevated Expression of SLC6A4 Encoding the Serotonin Transporter (SERT) in Gilles de la Tourette Syndrome

Genes ◽

10.3390/genes12010086 ◽

2021 ◽

Vol 12 (1) ◽

pp. 86

Author(s):

Mathis Hildonen ◽

Amanda M. Levy ◽

Christina Dahl ◽

Victoria A. Bjerregaard ◽

Lisbeth Birk Møller ◽

...

Keyword(s):

Tourette Syndrome ◽

Serotonin Transporter ◽

Neurodevelopmental Disorder ◽

Control Group ◽

Obsessive Compulsive ◽

Expression Levels ◽

Compulsive Disorder ◽

Hyperactivity Disorder ◽

Elevated Expression ◽

Gene Expression Levels

Gilles de la Tourette syndrome (GTS) is a complex neurodevelopmental disorder characterized by motor and vocal tics. Most of the GTS individuals have comorbid diagnoses, of which obsessive-compulsive disorder (OCD) and attention deficit-hyperactivity disorder (ADHD) are the most common. Several neurotransmitter systems have been implicated in disease pathogenesis, and amongst these, the dopaminergic and the serotonergic pathways are the most widely studied. In this study, we aimed to investigate whether the serotonin transporter (SERT) gene (SLC6A4) was differentially expressed among GTS individuals compared to healthy controls, and whether DNA variants (the SERT-linked polymorphic region 5-HTTLPR, together with the associated rs25531 and rs25532 variants, and the rare Ile425Val variant) or promoter methylation of SLC6A4 were associated with gene expression levels or with the presence of OCD as comorbidity. We observed that SLC6A4 expression is upregulated in GTS individuals compared to controls. Although no specific genotype, allele or haplotype was overrepresented in GTS individuals compared to controls, we observed that the LAC/LAC genotype of the 5-HTTLPR/rs25531/rs25532 three-locus haplotype was associated with higher SLC6A4 mRNA expression levels in GTS individuals, but not in the control group.

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