P0605 LIPID METABOLISM DISORDER AT WOMEN WITH GESTATIONAL DIABETES MELLITUS IN KOSOVA

Abstract Introduction Gestational diabetes mellitus (GDM) exhibit altered placental lipid metabolism. The molecular basis of this altered metabolism is not clear. Altered placental expression of proteins of lipogenesis and fatty acid oxidation may be involved in the placental accumulation of triacylglycerols (TG). The present study was aimed at investigating the differential expressions of placental proteins related to lipid metabolism among GDM women in comparison with control pregnant women (CPW) and to correlate them with maternal and fetal lipid parameters as well as altered fetal growth. Materials and Methods Maternal blood, cord blood, and placental samples were collected from GDM and CPW. The biochemical parameters, glucose, lipid profile and free fatty acids (FFA) were measured. The placental TG content was measured. Differential placental expressions of proteins; phosphatidylinositol-3-kinase (PI3K) p85α, PI3K p110α,liver X receptor alpha (LXRα), sterol regulatory element binding protein1(SREBP1), fatty acid synthase (FAS), stearyl CoA desaturase1 (SCD1), lipoprotein lipase (LPL),Peroxisome proliferator-activated receptor (PPAR)α and PPARγ were analysed by western blotting and immunohistochemistry. Results Placental protein expressions of PI3K p110α, LXRα, FAS, SCD1, and LPL were found to be significantly higher, whereas PPARα and PPARγ were lower in GDM women compared with CPW. The placental TG content and cord plasma FFA were increased in GDM women compared with CPW. The placental TG content positively correlated with Ponderal index of GDM new-borns. Conclusion Differential expressions of placental proteins related to lipid metabolism in GDM might have led to placental TG accumulation. This might have contributed to the fetal overgrowth in GDM.

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Pro-Inflammatory Cytokines, Lipid Metabolism and Inflammation in Gestational Diabetes Mellitus as Cause of Insulin Resistance

Gestational Diabetes - Causes, Diagnosis and Treatment ◽

10.5772/55634 ◽

2013 ◽

Cited By ~ 1

Author(s):

Alexander E.

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Lipid Metabolism ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Inflammatory Cytokines ◽

Pro Inflammatory Cytokines

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Influence of Glycemic Control on Coagulation and Lipid Metabolism in Pregnancies Complicated by Pregestational and Gestational Diabetes Mellitus

Advances in Experimental Medicine and Biology - Advances in Biomedicine ◽

10.1007/5584_2019_382 ◽

2019 ◽

pp. 81-88 ◽

Cited By ~ 2

Author(s):

Justyna Teliga-Czajkowska ◽

Jacek Sienko ◽

Julia Zareba-Szczudlik ◽

Aneta Malinowska-Polubiec ◽

Ewa Romejko-Wolniewicz ◽

...

Keyword(s):

Diabetes Mellitus ◽

Lipid Metabolism ◽

Glycemic Control ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus

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Quercetin Improves Glucose and Lipid Metabolism of Diabetic Rats: Involvement of Akt Signaling and SIRT1

Journal of Diabetes Research ◽

10.1155/2017/3417306 ◽

2017 ◽

Vol 2017 ◽

pp. 1-10 ◽

Cited By ~ 28

Author(s):

Jing Peng ◽

Qingde Li ◽

Keye Li ◽

Li Zhu ◽

Xiaoding Lin ◽

...

Keyword(s):

Diabetes Mellitus ◽

Lipid Metabolism ◽

Fasting Blood Glucose ◽

Akt Signaling ◽

Hepatic Glycogen ◽

High Dose ◽

Lipid Metabolism Disorder ◽

Metabolism Disorder ◽

Glucose And Lipid Metabolism ◽

Quercetin Treatment

Glucose and lipid metabolism disorder in diabetes mellitus often causes damage to multiple tissues and organs. Diabetes mellitus is beneficially affected by quercetin. However, its concrete mechanisms are yet to be fully elucidated. In our study, diabetes was induced in Sprague-Dawley rats by STZ injection. The rats were randomly divided into normal control, diabetic model, low-dose quercetin treatment, high-dose quercetin treatment, and pioglitazone treatment groups. Fasting blood glucose was collected to evaluate diabetes. Immunohistochemistry and fluorometric assay were performed to explore SIRT1. Akt levels were measured through immunoprecipitation and Western blot. After 12 weeks of quercetin treatment, the biochemical parameters of glucose and lipid metabolism improved to varying degrees. Hepatic histomorphological injury was alleviated, and hepatic glycogen content was increased. The expression and activity of hepatic SIRT1 were enhanced, and Akt was activated by phosphorylation and deacetylation. These results suggested that the beneficial effects of quercetin on glucose and lipid metabolism disorder are probably associated with the upregulated activity and protein level of SIRT1 and its influence on Akt signaling pathway. Hence, quercetin shows potential for the treatment of glucose and lipid metabolism disorder in diabetes mellitus.

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Gestational diabetes mellitus causes dyslipidemia in late trimester: mini review

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20195600 ◽

2019 ◽

Vol 9 (1) ◽

pp. 453

Author(s):

Poonguzhalai S. ◽

Kalyanikutty K. P.

Keyword(s):

Diabetes Mellitus ◽

Lipid Metabolism ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Gestational Age ◽

Significant Risk ◽

Normal Pregnancy ◽

Adverse Outcomes ◽

Peripheral Tissues ◽

Management Protocol

The incidence of gestational diabetes mellitus (GDM) is increasing rapidly worldwide. Many women with gestational diabetes mellitus are likely to have type 2 diabetes. With the extensive management protocol for GDM we are able to obtain a good glycaemic control but still excess morbidity prevails among GDM pregnancy compared to normal pregnancy. This may be due to the dysfunction of lipid metabolism. Changes in carbohydrate and lipid metabolism occur during pregnancy to ensure a continuous supply of nutrients to the growing fetus despite intermittent maternal food intake. Exaggerated reduction in insulin sensitivity in the peripheral tissues combined with peripheral adipose tissue lipolysis in GDM pregnancy than normal pregnancy results in increased maternal lipoprotein concentrations and elevated lipoprotein triglyceride content. An altered lipid profile on the maternal side would modulate the quantity and quality of lipids being transferred to the fetus. Hypertriacylglycerolemia in gestational diabetes mellitus has been related to a significant risk of having neonates that are large for gestational age and it is considered as a major cause of preeclampsia in the late gestational age. So, the recent researchers emphasize on targeting lipid metabolism in pregnant women with GDM to avoid the adverse outcomes of pregnancy.

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