Definition of genetic instability as prognostic factor in colorectal cancer by microsatellite analysis and immunohistochemistry of an archival collection of patients. Comparison between sporadic and familial cases

Background : Liver metastases of colorectal cancer are frequent and potentially fatal event in the evolution of patients with these tumors. Aim : In this module, was contextualized the clinical situations and parameterized epidemiological data and results of the various treatment modalities established. Method: Was realized deep discussion on detecting and staging metastatic colorectal cancer, as well as employment of imaging methods in the evaluation of response to instituted systemic therapy. Results : The next step was based on the definition of which patients would have their metastases considered resectable and how to expand the amount of patients elegible for modalities with curative intent. Conclusion : Were presented clinical, pathological and molecular prognostic factors, validated to be taken into account in clinical practice.

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SLIRP, a Nuclear Receptor Coregulator, Is a Good Prognostic Factor in Colorectal Cancer

10.1210/endo-meetings.2011.part1.p1.p1-30 ◽

2011 ◽

pp. P1-30-P1-30 ◽

Cited By ~ 1

Author(s):

Patrick A Candy ◽

Shane M Colley ◽

Michael Phillips ◽

Andrew Davidson ◽

Barry Iacopetta ◽

...

Keyword(s):

Colorectal Cancer ◽

Prognostic Factor ◽

Nuclear Receptor

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ThE uSE of AbErrAnT METhylATEd gEnES SEPT9 And VIM for clInIcAl dIAgnoSIS of colorEcTAl cAncEr

Clinical Practice ◽

10.17816/clinpract7415-20 ◽

2016 ◽

Vol 7 (4) ◽

pp. 15-20

Author(s):

O I Brovkina ◽

M G Gordiev ◽

D S Khodyrev ◽

A G Nikitin ◽

A V Averyanov

Keyword(s):

Colorectal Cancer ◽

High Sensitivity ◽

Test System ◽

Aberrant Methylation ◽

Adjacent Tissue ◽

Epigenetic Events ◽

Combined Use ◽

Ras Family ◽

Definition Of ◽

Tumor Dna

Definition of epigenetic disorders is important for early diagnosis of colorectal cancer. To obtain a model of diagnostic test system with high sensitivity and specificity, we determined the frequency of methylation in SEPT9 and VIM genes. Epigenetic events also were compared with mutations in the RAS family genes. It was confirmed the presence of aberrant methylation in SEPT9 and VIM genes in tumor cells. DNA of tumor samples was significantly more methylated than samples with DNA from adjacent tissue (P = 8,67E-19 for SEPT9 gene and P=8,68E-19 for VIM gene). In the group of patients carried mutations in KRAS or NRAS genes tumor DNA significantly more methylated in gene SEPT9 (P = 0.0018), in contrast to the tumor DNA from patients not carried mutations. We have demonstrated that the combined use of methylation markers can improve the sensitivity of the test systems used in the diagnostics of colon cancer.

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Risk factors in the recurrence of the colorectal cancer

Acta chirurgica iugoslavica ◽

10.2298/aci0202040u ◽

2002 ◽

Vol 49 (2) ◽

pp. 40-43 ◽

Cited By ~ 1

Author(s):

J. Ulanska ◽

A. Dziki ◽

W. Langner

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Rectal Cancer ◽

Local Recurrence ◽

Early Stage ◽

Concomitant Treatment ◽

Preventive Chemotherapy ◽

Tnm System ◽

Definition Of ◽

Colorectal Cancer Patients

Traditionally, the clinical outcome of colorectal cancer patients may be predicted by pathological staging by either Dukes staging or the UICC-TNM system. However, some of Dukes stage A (approximately 10% of patients) and Dukes B patients (30-40%) will develop local recurrence or distant metastasis years after receiving standard surgical treatments. Therefore it is important to find some other indicators that can predict for recurrence so that we can screen for high-risk early-stage patients who may need preventive chemotherapy or other adjuvant therapy. The aim of this study is determination of risk factor for local recurrence in rectal cancer. In this study there has been used and summarized also research records and publications from different clinical hospitals according to actual international literature. Part of elements connected with patient, tumor and genetic and immunological factors remains independent on curative procedures. However better investigation these factors might affect on therapy, frequency of follow-up examinations, and help to detect recurrence at very early phase. Concomitant treatment factors are able to be moderate by surgeons and therapeutics. Therefore precise definition of risk factors might be helpful in decrease recurrence rate in patients with rectal cancer.

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