65 Phase II drug metabolism UGT1A enzyme affects cellular response of colon cancer cells to antitumor triazoloacridinone C-1305 treatment

2014 ◽  
Vol 50 ◽  
pp. 26
Author(s):  
E. Augustin ◽  
E. Bartusik ◽  
A. Theus ◽  
B. Borowa-Mazgaj ◽  
Z. Mazerska
Keyword(s):  
Colon Cancer ◽  
Drug Metabolism ◽  
Cancer Cells ◽  
Phase Ii ◽  
Cellular Response ◽  
Colon Cancer Cells ◽  
Phase Ii Drug Metabolism

Inhibition of topoisomerase II by phase II metabolites of resveratrol in human colon cancer cells

2015 ◽  
Vol 59 (12) ◽  
pp. 2448-2459 ◽  
Author(s):  
Anika Schroeter ◽  
Isabel Anna Maria Groh ◽  
Giorgia Del Favero ◽  
Marc Pignitter ◽  
Katharina Schueller ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Phase Ii ◽  
Topoisomerase Ii ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Phase Ii Metabolites ◽  
Human Colon Cancer Cells

Phase-II metabolism limits the antiproliferative activity of urolithins in human colon cancer cells

2013 ◽  
Vol 53 (3) ◽  
pp. 853-864 ◽  
Author(s):  
Antonio González-Sarrías ◽  
Juan Antonio Giménez-Bastida ◽  
María Ángeles Núñez-Sánchez ◽  
Mar Larrosa ◽  
María Teresa García-Conesa ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Phase Ii ◽  
Antiproliferative Activity ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Phase Ii Metabolism ◽  
Human Colon Cancer Cells

scholarly journals MicroRNA Response and Toxicity of Potential Pathways in Human Colon Cancer Cells Exposed to Titanium Dioxide Nanoparticles

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1236 ◽  
Author(s):  
Wen Li ◽  
Ming Xi Jia ◽  
Jing Deng ◽  
Jian Hui Wang ◽  
Zavuga Zuberi ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Titanium Dioxide ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cellular Response ◽  
Titanium Dioxide Nanoparticles ◽  
Hct116 Cell ◽  
Valuable Insight ◽  
Colon Cancer Cells ◽  
Tio2 Nps

Titanium dioxide nanoparticles (TiO2-NPs) are widely used for biomedical and food applications, the toxicity of TiO2-NPs in vivo and in vitro has been elucidated, but the underlying cytotoxicity of TiO2-NPs against microRNA remains largely unknown. The purpose of this study was to analyze microRNA profiling induced by TiO2-NPs against NCM460 and HCT116 cell lines. Comparative analysis identified 34 and 24 microRNAs were significantly altered in the TiO2-NPs treated cells at concentrations of 3 μg/mL and 30 μg/mL, respectively. Functional classification demonstrated that a large proportion of genes involved in metabolism, human disease, and environmental information process were significantly upregulated by TiO2-NPs. Bioinformatics analysis suggested that microRNA 378 might be an early indicator of cellular response to exogenous stimuli with apoptotic signals. Furthermore, TiO2-NPs significantly altered the expression of microRNA 378b and 378g in HCT116 and NCM460 cell lines at different concentrations from 3 to 6 μg/mL. These concentrations elicit high-sensitivity of stimuli response in colon cancer cells when exposed to the slight doses of TiO2-NPs. Our study indicated that microRNAs 378b and 378g may play an important role in TiO2-NPs-mediated colonic cytotoxicity, which may provide a valuable insight into the molecular mechanisms of potential risks in colitis and colon cancer.

Leptin is a growth factor for human colon cancer cells

2001 ◽  
Vol 120 (5) ◽  
pp. A493-A493
Author(s):  
J HARDWICK ◽  
G VANDENBRINK ◽  
S VANDEVENTER ◽  
M PEPPELENBOSCH
Keyword(s):  
Colon Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

Silencing of a death associated protein kinase as a pro-survival factor in colon cancer cells

Endoscopy ◽  
2005 ◽  
Vol 37 (05) ◽  
Author(s):  
GA Doherty ◽  
SM Byrne ◽  
SC Austin ◽  
GM Scully ◽  
EW Kay ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
Survival Factor ◽  
Death Associated Protein Kinase

Cytotoxic Effect of the Combination of Gemcitabine and Atorvastatin Loaded in Microemulsion on the HCT116 Colon Cancer Cells

2017 ◽  
Vol 9 (2) ◽  
Author(s):  
Mayson H. Alkhatib ◽  
Dalal Al-Saedi ◽  
Wadiah S. Backer
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Therapeutic Potential ◽  
Morphological Changes ◽  
In Vitro Study ◽  
Colon Cancer Cells ◽  
Apoptosis Detection ◽  
Hct116 Cells

The combination of anticancer drugs in nanoparticles has great potential as a promising strategy to maximize efficacies by eradicating resistant, reduce the dosage of the drug and minimize toxicities on the normal cells. Gemcitabine (GEM), a nucleoside analogue, and atorvastatin (ATV), a cholesterol lowering agent, have shown anticancer effect with some limitations. The objective of this in vitro study was to evaluate the antitumor activity of the combination therapy of GEM and ATVencapsulated in a microemulsion (ME) formulation in the HCT116 colon cancer cells. The cytotoxicity and efficacy of the formulation were assessed by the 3- (4,5dimethylthiazole-2-yl)-2,5-diphyneltetrazolium bromide (MTT) assay. The mechanism of cell death was examined by observing the morphological changes of treated cells under light microscope, identifying apoptosis by using the ApopNexin apoptosis detection kit, and viewing the morphological changes in the chromatin structure stained with 4′,6-diamidino-2-phenylindole (DAPI) under the inverted fluorescence microscope. It has been found that reducing the concentration of GEM loaded on ME (GEM-ME) from 5μM to 1.67μM by combining it with 3.33μM of ATV in a ME formulation (GEM/2ATV-ME) has preserved the strong cytotoxicity of GEM-ME against HCT116 cells. The current study proved that formulating GEM with ATV in ME has improved the therapeutic potential of GEM and ATV as anticancer drugs.

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