scholarly journals Development of silicon fluoride acceptor (SiFA)-conjugated antibodies targeting TREM2 and Poly-GA repeats as new tracers for PET imaging of neurodegenerative diseases

2021 ◽  
Vol 96-97 ◽  
pp. S37
Author(s):  
Monireh Shojaei ◽  
Christian Haass ◽  
Dieter Edbauer ◽  
Kai Schlepckow ◽  
Peter Bartenstein ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Pet Imaging ◽  
Silicon Fluoride

scholarly journals The Place of PET to Assess New Therapeutic Effectiveness in Neurodegenerative Diseases

2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
Anne-Claire Dupont ◽  
Bérenger Largeau ◽  
Denis Guilloteau ◽  
Maria Joao Santiago Ribeiro ◽  
Nicolas Arlicot
Keyword(s):  
Neurodegenerative Diseases ◽  
Pet Imaging ◽  
Molecular Mechanisms ◽  
Individual Variability ◽  
Response To Therapy ◽  
Therapeutic Effectiveness ◽  
Imaging Method ◽  
Detection And Identification ◽  
Positron Emission

In vivo exploration of neurodegenerative diseases by positron emission tomography (PET) imaging has matured over the last 20 years, using dedicated radiopharmaceuticals targeting cellular metabolism, neurotransmission, neuroinflammation, or abnormal protein aggregates (beta-amyloid and intracellular microtubule inclusions containing hyperphosphorylated tau). The ability of PET to characterize biological processes at the cellular and molecular levels enables early detection and identification of molecular mechanisms associated with disease progression, by providing accurate, reliable, and longitudinally reproducible quantitative biomarkers. Thus, PET imaging has become a relevant imaging method for monitoring response to therapy, approved as an outcome measure in bioclinical trials. The aim of this paper is to review and discuss the current inputs of PET in the assessment of therapeutic effectiveness in neurodegenerative diseases connected by common pathophysiological mechanisms, including Parkinson’s disease, Huntington’s disease, dementia, amyotrophic lateral sclerosis, multiple sclerosis, and also in psychiatric disorders. We also discuss opportunities for PET imaging to drive more personalized neuroprotective and therapeutic strategies, taking into account individual variability, within the growing framework of precision medicine.

P3-084: Cerebrospinal fluid Tau and Aβ measurement and amyloid PET imaging in neurodegenerative diseases

2008 ◽  
Vol 4 ◽  
pp. T542-T542
Author(s):  
Qiao-Xin Li ◽  
Katrina M. Laughton ◽  
Steve J. Collins ◽  
Victor L. Villemagne ◽  
Christopher C. Rowe ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Neurodegenerative Diseases ◽  
Pet Imaging ◽  
Amyloid Pet ◽  
Amyloid Pet Imaging

scholarly journals Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases

2020 ◽  
Author(s):  
Elizabeth C. Mormino ◽  
Tyler N. Toueg ◽  
Carmen Azevedo ◽  
Jessica B. Castillo ◽  
Wanjia Guo ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Pet Imaging ◽  
Tau Pet ◽  
Tau Pet Imaging

scholarly journals PET/SPECT imaging agents for neurodegenerative diseases

2014 ◽  
Vol 43 (19) ◽  
pp. 6683-6691 ◽  
Author(s):  
Lin Zhu ◽  
Karl Ploessl ◽  
Hank F. Kung
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Neurodegenerative Diseases ◽  
Pet Imaging ◽  
Amyloid Plaque ◽  
Spect Imaging ◽  
Imaging Agents ◽  
Plaque Deposition ◽  
Β Amyloid

Amyvid/PET imaging of a living brain detects β-amyloid plaque deposition, a risk factor for developing Alzheimer's disease.

Development of subnanomolar radiofluorinated (2-pyrrolidin-1-yl)imidazo[1,2-b]pyridazine pan-Trk inhibitors as candidate PET imaging probes

MedChemComm ◽  
2015 ◽  
Vol 6 (12) ◽  
pp. 2184-2193 ◽  
Author(s):  
Vadim Bernard-Gauthier ◽  
Justin J. Bailey ◽  
Arturo Aliaga ◽  
Alexey Kostikov ◽  
Pedro Rosa-Neto ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Diseases ◽  
Pet Imaging ◽  
Receptor Kinases ◽  
Imaging Probes ◽  
Trk Inhibitors

Dysregulation of tropomyosin receptor kinases (TrkA/B/C) expression and signalling is recognized as a hallmark of numerous neurodegenerative diseases including Parkinson's, Huntington's and Alzheimer's disease.

scholarly journals Current paradigm of the 18-kDa translocator protein (TSPO) as a molecular target for PET imaging in neuroinflammation and neurodegenerative diseases

2011 ◽  
Vol 3 (1) ◽  
pp. 111-119 ◽  
Author(s):  
Alex Sik Chung Ching ◽  
Bertrand Kuhnast ◽  
Annelaure Damont ◽  
Dirk Roeda ◽  
Bertrand Tavitian ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Pet Imaging ◽  
Molecular Target ◽  
Translocator Protein ◽  
Current Paradigm

Autophagy and ageing: implications for age-related neurodegenerative diseases

2013 ◽  
Vol 55 ◽  
pp. 119-131 ◽  
Author(s):  
Bernadette Carroll ◽  
Graeme Hewitt ◽  
Viktor I. Korolchuk
Keyword(s):  
Neurodegenerative Diseases ◽  
Energy Availability ◽  
Future Studies ◽  
Intracellular Degradation ◽  
Age Related ◽  
Autophagy Induction ◽  
Social Importance ◽  
Cellular Dysfunction ◽  
Autophagy Activity ◽  
Intense Research

Autophagy is a process of lysosome-dependent intracellular degradation that participates in the liberation of resources including amino acids and energy to maintain homoeostasis. Autophagy is particularly important in stress conditions such as nutrient starvation and any perturbation in the ability of the cell to activate or regulate autophagy can lead to cellular dysfunction and disease. An area of intense research interest is the role and indeed the fate of autophagy during cellular and organismal ageing. Age-related disorders are associated with increased cellular stress and assault including DNA damage, reduced energy availability, protein aggregation and accumulation of damaged organelles. A reduction in autophagy activity has been observed in a number of ageing models and its up-regulation via pharmacological and genetic methods can alleviate age-related pathologies. In particular, autophagy induction can enhance clearance of toxic intracellular waste associated with neurodegenerative diseases and has been comprehensively demonstrated to improve lifespan in yeast, worms, flies, rodents and primates. The situation, however, has been complicated by the identification that autophagy up-regulation can also occur during ageing. Indeed, in certain situations, reduced autophagosome induction may actually provide benefits to ageing cells. Future studies will undoubtedly improve our understanding of exactly how the multiple signals that are integrated to control appropriate autophagy activity change during ageing, what affect this has on autophagy and to what extent autophagy contributes to age-associated pathologies. Identification of mechanisms that influence a healthy lifespan is of economic, medical and social importance in our ‘ageing’ world.

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