46 DETECTION OF HBV GENOTYPE C IN HEPATOCELLULAR CARCINOMA PATIENTS FROM NORTH-EAST INDIA

Abstract Objective To investigate the occurrence of basal core promoter (BCP) and pre-C mutations in patients with hepatitis B virus (HBV) infection in Gansu Province, China, and to analyze the correlation of HBV mutation and HBV genotype with primary hepatocellular carcinoma (HCC). Methods PCR-RFLP was applied to detect HBV subgenotypes, and the presence of the pre-C and BCP mutations in 62 patients with HCC, 70 patients with hepatitis B induced liver cirrhosis (LC) and 90 patients with chronic hepatitis B (CHB). Results In HCC patients, genotype C was the major genotype (70.97%). The pre-C mutation was found in 59.68%, 31.43% and 16.67% patients with HCC, LC and CHB, respectively. The frequency of BCP mutations was significantly different between patients with HCC, LC and CHB (74.19%, 51.43% and 37.78%, respectively; X2=30.727, 19.540, respectively, P < 0.01). Patients in HCC group had a higher incidence of pre-C as well as BCP mutations compared to the other groups. The prevalence of pre-C and BCP mutations was significantly higher in patients with genotype C1 (44.32% and 69.32%, respectively) compared to patients with other subgenotypes (P < 0.05). Conclusions The incidence of pre-C and BCP mutations increases with disease progression. Pre-C and BCP mutations frequently occur in patients with genotype C1. HBV genotype C, pre-C mutations and BCP mutations are closely related to the occurrence of HCC.

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High Viral Load and Hepatitis B Virus Subgenotype Ce Are Associated With Increased Risk of Hepatocellular Carcinoma

Journal of Clinical Oncology ◽

10.1200/jco.2007.13.2043 ◽

2008 ◽

Vol 26 (2) ◽

pp. 177-182 ◽

Cited By ~ 200

Author(s):

Henry Lik-Yuen Chan ◽

Chi-Hang Tse ◽

Frankie Mo ◽

Jane Koh ◽

Vincent Wai-Sun Wong ◽

...

Keyword(s):

Risk Factors ◽

Hepatocellular Carcinoma ◽

Hepatitis B Virus ◽

Hepatitis B ◽

Hbv Dna ◽

Hazard Ratio ◽

Hbv Genotype ◽

Hbv Genotypes ◽

B Virus ◽

Genotype C

Purpose We aimed to investigate the impact of hepatitis B virus (HBV) DNA and HBV genotypes/subgenotypes on the risk of hepatocellular carcinoma (HCC). Patients and Methods A prospective cohort of patients infected with chronic HBV in a surveillance program for HCC since 1997 was studied. Ultrasound and alpha-fetoprotein evaluation were regularly performed to detect HCC. Risk factors for HCC and the relationship between HBV DNA and HBV genotypes were determined. Results Among 1,006 patients with a median follow-up of 7.7 years, 86 patients (8.5%) developed HCC. With reference to the low HBV DNA stratum (log HBV DNA ≤ 4.5 copies/mL), the hazard ratio for HCC of the intermediate HBV DNA stratum (log HBV DNA > 4.5 to 6.5 copies/mL) was 1.62 (95% CI, 1.05 to 2.48; P = .027) and that of the high HBV DNA stratum (log HBV DNA > 6.5 copies/mL) was 2.73 (95% CI, 1.76 to 4.25; P < .001). Among patients with genotyping results, 330 patients had HBV genotype B and 439 patients had HBV genotype C (94 subgenotype Ce and 345 subgenotype Cs). With reference to HBV genotype B, HBV subgenotype Ce has the highest risk of HCC (hazard ratio = 2.75; 95% CI, 1.66 to 4.56; P < .0001) and HBV subgenotype Cs has intermediate risk (hazard ratio = 1.70; 95% CI, 1.09 to 2.64; P = .020). On multivariate analysis, HBV DNA, HBV genotypes, liver cirrhosis, male sex, older age, and lower serum albumin were independent risk factors of HCC. Conclusion High HBV DNA level and HBV genotype C, particularly subgenotype Ce, increased the risk of HCC in chronic hepatitis B.

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North east India gets microbial diversity database

Nature India ◽

10.1038/nindia.2014.55 ◽

2014 ◽

Keyword(s):

Microbial Diversity ◽

North East India ◽

North East

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New plant species discovered in north-east India

Nature India ◽

10.1038/nindia.2018.15 ◽

2018 ◽

Keyword(s):

Plant Species ◽

North East India ◽

North East

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Health Challenges of Cities in Developing Countries: A Study of Guwahati City in North- East India

International Conference on Trends in Economics, Humanities and Management (ICTEHM'14) Aug 13-14, 2014 Pattaya (Thailand) ◽

10.15242/icehm.ed0814005 ◽

2014 ◽

Cited By ~ 1

Keyword(s):

Developing Countries ◽

North East India ◽

North East ◽

Guwahati City

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Past Verses Present; Metamorphosis in Different Spheres of Guwahati: A Study of Srutimala Duara’s Mindprints of Guwahati

SMART MOVES JOURNAL IJELLH ◽

10.24113/ijellh.v8i2.10421 ◽

2020 ◽

Vol 8 (2) ◽

pp. 13

Author(s):

Ankita Pandey

Keyword(s):

Point Of View ◽

Areca Nut ◽

Medieval Period ◽

River Bank ◽

North East India ◽

North East ◽

The North ◽

Indian State ◽

The City ◽

Beautiful City

Guwahati derives its name from the Assamese word “Guwa” means areca nut and “Haat” means market. However, the modern Guwahati had been known as the ancient Pragjyotishpura and was the capital of Assam under the Kamrupa kingdom. A beautiful city Guwahati is situated on the south bank of the river Bramhaputra. Moreover, It is known as the largest city in the Indian state of Assam and also the largest metropolis in North East India. It has also its importance as the gateway to the North- East India. Assamese and English are the spoken languages in Guwahati. In 1667, the Mogul forces were defeated in the battle by the Ahom forces commanded by Lachut Barphukan. Thus, in a sense Guwahati became the bone of contention among the Ahoms, Kochas and the Moguls during the medieval period. Guwahati the administrative headquarters of Lower Assam with a viceroy or Barbhukan was made by the Ahom king. Since 1972 it has been the capital of Assam. The present paper will discuss the changes happened in Guwahati over the period of late 1970s till the present time. It will focus on the behavior of people, transformed temples, Panbazar of the city, river bank of Bramhaputra, old Fancy Bazaar, chaotic ways, festivals and seasons including a fifth man made season etc. It will also deal how over the years a city endowed with nature’s gifts and scenic views, has been changing as “a dirty city”. Furthermore, it will also present the insurgencies that have barged into the city. The occurrence of changes will be discussed through the perspective and point of view of Srutimala Duara as presented in her book Mindprints of Guwahati.

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The Subaltern Speak- A Study On The Culture Of The Arunachalis With Special Reference To Mamang Dai’s The Legends Of Pensam

History Research Journal ◽

10.26643/hrj.v5i4.6986 ◽

2019 ◽

Vol 5 (4) ◽

pp. 14-20

Author(s):

Ms. Cheryl Antonette Dumenil ◽

Dr. Cheryl Davis

Keyword(s):

Special Reference ◽

Small World ◽

Natural World ◽

Arunachal Pradesh ◽

North East India ◽

North East ◽

Shared History ◽

History Of ◽

And Gender ◽

Insight Into

North- East India is an under veiled region with an awe-inspiring landscape, different groups of ethnic people, their culture and heritage. Contemporary writers from this region aspire towards a vision outside the tapered ethnic channel, and they represent a shared history. In their writings, the cultural memory is showcased, and the intensity of feeling overflows the labour of technique and craft. Mamang Dai presents a rare glimpse into the ecology, culture, life of the tribal people and history of the land of the dawn-lit mountains, Arunachal Pradesh, through her novel The Legends of Pensam. The word ‘Pensam’ in the title means ‘in-between’, but it may also be interpreted as ‘the hidden spaces of the heart’. This is a small world where anything can happen. Being adherents of the animistic faith, the tribes here believe in co-existence with the natural world along with the presence of spirits in their forests and rivers. This paper attempts to draw an insight into the culture and gender of the Arunachalis with special reference to The Legends of Pensam by Mamang Dai.

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