Antifertility Activity of Hydroalcoholic Extract of Ocimum Basilicum Linn. Leaves on Female Wistar Rats

The plants that compound the Pfaffia genus are used in folk medicine to treat gastric disturbances. This study examined the effects of a crude hydroalcoholic extract of Pfaffia sp on the gastrointestinal tract. Female Wistar rats were pretreated orally (p.o.) with the hydroalcoholic extract of Pfaffia (0.5, 1 and 2 g.kg-1) before the induction of ulcer with hypothermic restraint stress (HRS), ethanol (ET) or indomethacin (IND). Control animals received water (C) or ranitidine (60mg/kg) p.o. The hydroalcoholic extract of Pfaffia (0.5, 1 and 2 mg.kg-1) protected rats against HRS and ET - induced ulcers, but was not able to protect the gastric mucosa against IND - induced ulcers. When injected into the duodenal lumen, the hydroalcoholic extract of Pfaffia inhibited basal and stimulated acid secretion in pylorus-ligated rats. These results indicate that this plant has a protective action against gastric lesions of the mucosa involving the reduction of gastric acid secretion.

Download Full-text

Pro-fertility effects of hydroalcoholic extract of Psidium guajava leaves in female Wistar rats

Advances in Traditional Medicine ◽

10.1007/s13596-021-00579-2 ◽

2021 ◽

Author(s):

Saleh Adamu Abwage ◽

Saganuwan Alhaji Saganuwan ◽

Solomon Tsekohol Agu ◽

Hyacinth Adakole Abu

Keyword(s):

Wistar Rats ◽

Psidium Guajava ◽

Hydroalcoholic Extract ◽

Female Wistar Rats

Download Full-text

Anxiolytic-like effect of hydroalcoholic extract of ripe pistachio hulls in adult female Wistar rats and its possible mechanisms

Research in Pharmaceutical Sciences ◽

10.4103/1735-5362.194870 ◽

2016 ◽

Vol 11 (6) ◽

pp. 454 ◽

Cited By ~ 2

Author(s):

Mohammad Rostampour ◽

Elham Hadipour ◽

Shahrbano Oryan ◽

Bahram Soltani ◽

Farshid Saadat

Keyword(s):

Adult Female ◽

Wistar Rats ◽

Hydroalcoholic Extract ◽

Female Wistar Rats

Download Full-text

Impact of environments factors in reproductive function: Protective effect of cinnamon against the mercury chloride induced toxicity in female Wistar rats (ovary and brain)

South Asian Journal of Experimental Biology ◽

10.38150/sajeb.9(3).p114-123 ◽

2019 ◽

Vol 9 (3) ◽

pp. 114-123

Author(s):

Dali Ouzna ◽

Zouba Mouad ◽

Sebti Baghded ◽

Mai Hichem ◽

Bouazza Sofiane ◽

...

Keyword(s):

Wistar Rats ◽

Histological Study ◽

Ovarian Tissue ◽

Antioxidant Properties ◽

Treated Group ◽

Control Group ◽

Mercury Chloride ◽

Hydroalcoholic Extract ◽

Physiological Serum ◽

Female Wistar Rats

Mercury affects several organs and disrupts their functioning, and cinnamonis known for its antioxidant properties so in this study we evaluate the effectof cinnamon extract against the effect of mercury in ovary and brain. 20 female wistar rats were subdivided into four groups (01):received gavage andintraperitonial injection of physiological serum, (02): received gavage withphysiological serum and intraperitonial injection of HgCl2at dose of 0.25mg/Kg/BW/7days, (03): received gavage with hydroalcoholic extract of cinnamonat dose of 100mg/Kg/BW/7days and intraperitonial injection of physiologicalserum, (04): received gavage with hydroalcoholic extract of cinnamon atdose of 100mg/Kg/BW/7days and intraperitonial injection of HgCl2 at dose of0.25mg/Kg/BW/7days. Ovaries and brains were removed to weigh and prepared for histological study and blood were collected for hormonal study.The body weight increased significantly in the mercury-treated group (p =0.001) compared to the control group, a significant increase of left ovaries (p= 0.011) in the treated group with mercury compared to the other groups.The histological section on the brain of the mercury-treated group showsdiffuse cerebral fibrosis. Histological study shows an irregular developmentof ovarian follicles and an increase of atretic follicles in mercury treatedgroup, and cinnamon protect the ovary from the oxidative damage ofmercury. Cinnamon has protective effects against inflammation and oxidative stress in ovarian tissue and brain.

Download Full-text

ANTI-ESTROGENIC PROPERTIES OF ETHANOLIC LEAF EXTRACT OF BOERHAVIA DIFFUSA ON FEMALE WISTAR RATS.

10.1055/s-0037-1608549 ◽

2017 ◽

Author(s):

C Olajide Omolola ◽

J Okpuzor ◽

I Nnadozie Jane ◽

R Adewole Adeniyi

Keyword(s):

Wistar Rats ◽

Leaf Extract ◽

Female Wistar Rats ◽

Estrogenic Properties ◽

Ethanolic Leaf Extract ◽

Boerhavia Diffusa

Download Full-text

NEW DATA CONCERNING THE ROLE PLAYED BY PROGESTERONE IN THE CONTROL OF FOLLICULAR GROWTH IN THE RAT

Acta Endocrinologica ◽

10.1530/acta.0.0750569 ◽

1974 ◽

Vol 75 (3) ◽

pp. 569-578 ◽

Cited By ~ 29

Author(s):

G. Buffler ◽

S. Roser

Keyword(s):

Wistar Rats ◽

Venous Blood ◽

Oestrous Cycle ◽

Female Rats ◽

Cycle Duration ◽

Follicular Growth ◽

The Third ◽

Female Wistar Rats

ABSTRACT The mechanisms involved in the prolongation of the oestrous cycle following LH administration were studied in 4-day cyclic female Wistar rats. In females injected with LH on the morning of dioestrus I there was an increase in ovarian venous blood progesterone as compared with non-injected animals. In both LH-treated females, and those injected with progesterone on the morning of dioestrus I, a slowing up in follicular growth was observed from the afternoon of dioestrus I. The size of follicles greater than 400 urn present in LH or progesterone injected animals on the third day of cycle was similar to the size reached by the same range of follicles in non-injected animals on the second day of the cycle. Hence, the increase in endogenous ovarian progesterone elicited by LH was considered as the cause of the slowing up of follicular growth and therefore of the lengthening of the oestrous cycle duration in female rats injected with LH at the beginning of 4-day cycle.

Download Full-text