Overexpression of the small heat shock protein, hsp27, confers resistance to hyperthermia, but not to oxidative stress and UV-induced cell death, in a stably transfected squamous cell carcinoma cell line

1997 ◽  
Vol 39 (1) ◽  
pp. 90-95 ◽  
Author(s):  
Franz Trautinger ◽  
Claudia Kokesch ◽  
Irene Herbacek ◽  
Robert M. Knobler ◽  
Ingela Kindås-Mügge
Keyword(s):  
Oxidative Stress ◽  
Squamous Cell Carcinoma ◽  
Cell Death ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Cell Line ◽  
Carcinoma Cell ◽  
Small Heat Shock Protein ◽  
Squamous Cell Carcinoma Cell

Induction of the 72-kD Heat Shock Protein in Human Skin Melanoma and Squamous Cell Carcinoma Cell Lines

1995 ◽  
Vol 22 (12) ◽  
pp. 907-912 ◽  
Author(s):  
Tsutomu Muramatsu ◽  
Nobuhiko Kobayashi ◽  
Hideyuki Tada ◽  
Mitsuo Hatoko ◽  
Toshihiko Shirai
Keyword(s):  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Human Skin ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Skin Melanoma ◽  
Squamous Cell Carcinoma Cell ◽  
Carcinoma Cell Lines

Characterization of the Eugenol Effects on the Bioenergetic Profile of SCC-4 Human Squamous Cell Carcinoma Cell Line

2018 ◽  
Vol 69 (9) ◽  
pp. 2567-2570 ◽  
Author(s):  
Oana M. Duicu ◽  
Ioana Z. Pavel ◽  
Florin Borcan ◽  
Danina M. Muntean ◽  
Adelina Cheveresan ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Line ◽  
Squamous Cell ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Squamous Cell Carcinoma Cell ◽  
Human Squamous Cell Carcinoma ◽  
Extracellular Flux ◽  
Transport Chain

Eugenol (EU), the active ingredient in clove oil, is commonly used as successful therapeutic compound in dentistry due to its antiseptic and anti-inflammatory effects. Recent research studies suggest that eugenol has also a potential anti-cancer effect. This study was thereby purported to assess the effects of EU on the bioenergetic profile of the SCC-4 human squamous cell carcinoma cell line. To this aim, SCC-4 cells were treated for 24 hours with free EU and EU incorporated in polyurethane structures (50 �M each). Oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) were measured using the Seahorse XF-24e extracellular flux analyzer (Agilent Technologies Inc.). Analysis of the SCC-4 bioenergetic profile was performed in the presence of the classic modulators of the electron transport chain: oligomycin, FCCP, and antimycin A+rotenone. Our data showed that cells stimulated with free EU induced a decrease of OCR linked parameters and an increase of ECAR, effects that were abolished by the incorporation of EU in polyurethane structures. In conclusion, free eugenol elicits inhibitory effects on mitochondrial respiration in the SCC-4 cell line, a result that might be suggestive for its anti-tumoral effects.

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