P104 ONE-YEAR AND TWO-YEAR FOLLOW UP ANALYSIS OF CARTILAGE MORPHOLOGY USING QUANTITATIVE DESS AND FLASH 3 TESLA MR-IMAGING - A PILOT STUDY FOR THE OSTEOARTHRITIS INITIATIVE

Thirty-eight patients whose primary extremity or limb girdle osteosarcomas had been completely excised (37 amputations, one limb sparing procedure) were allocated at random to two treatment groups receiving respectively regular follow-up examinations plus a high-dose methotrexate (HDMTX) regimen or regular follow-up without primary adjuvant chemotherapy. Although the vincristine, HDMTX, leucovorin regimen was generally quite tolerable when given at three-week intervals for one year and most of the chemotherapy patients followed the planned HDMTX dose escalations from 3 to 6 to 7.5 g/m2, delayed methotrexate excretion limited dosage escalations in 25%. An estimated 52% of the 38 patients were surviving five years after randomization and an estimated 42% remained continuously relapse-free after five years. No significant differences between the outcomes of the 20 treated and the 18 untreated patients were apparent; however, power to detect differences was low. Furthermore, no significant differences in postmetastasis survival were apparent between the 12 treated and 10 untreated patients who relapsed. Approximately 20% of these failing patients appear to have been salvaged for long-term survival. This pilot study of HDMTX confirms the continuing need for controlled clinical trials in determining the therapeutic value of adjuvant chemotherapy programs for patients with primary osteosarcoma.

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954 Infliximab Maintenance Beyond One Year Prevents Postoperative Crohn's Disease Recurrence: Long-Term Follow-up From the Randomized Controlled Pilot Study

Gastroenterology ◽

10.1016/s0016-5085(13)60618-6 ◽

2013 ◽

Vol 144 (5) ◽

pp. S-173 ◽

Cited By ~ 4

Author(s):

Miguel Regueiro ◽

Leonard Baidoo ◽

Kevin E. Kip ◽

Jason M. Swoger ◽

David G. Binion ◽

...

Keyword(s):

Crohn’S Disease ◽

Pilot Study ◽

Crohn's Disease ◽

Disease Recurrence ◽

Randomized Controlled ◽

Long Term Follow Up ◽

One Year

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The effect of an intensive exercise programme on leg function in chronic stroke patients: a pilot study with one-year follow-up

Clinical Rehabilitation ◽

10.1177/0269215509335291 ◽

2009 ◽

Vol 23 (9) ◽

pp. 790-799 ◽

Cited By ~ 10

Author(s):

Roland Stock ◽

Paul Jarle Mork

Keyword(s):

Pilot Study ◽

Exercise Programme ◽

Chronic Stroke ◽

Stroke Patients ◽

Intensive Exercise ◽

One Year

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Male eating disorders and therapy: A controlled pilot study with one year follow-up

Journal of Behavior Therapy and Experimental Psychiatry ◽

10.1016/j.jbtep.2009.06.004 ◽

2009 ◽

Vol 40 (3) ◽

pp. 479-486 ◽

Cited By ~ 17

Author(s):

Fernando Fernández-Aranda ◽

Isabel Krug ◽

Susana Jiménez-Murcia ◽

Roser Granero ◽

Araceli Núñez ◽

...

Keyword(s):

Eating Disorders ◽

Pilot Study ◽

Male Eating Disorders ◽

One Year

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Prognostic value of cardiovascular MR imaging biomarkers on outcome in peripheral arterial disease: a 6-year follow-up pilot study

The International Journal of Cardiovascular Imaging ◽

10.1007/s10554-016-0908-y ◽

2016 ◽

Vol 32 (8) ◽

pp. 1281-1288 ◽

Cited By ~ 5

Author(s):

Harrie van den Bosch ◽

Jos Westenberg ◽

Wikke Setz-Pels ◽

Erik Kersten ◽

Alexander Tielbeek ◽

...

Keyword(s):

Pilot Study ◽

Mr Imaging ◽

Peripheral Arterial Disease ◽

Prognostic Value ◽

Arterial Disease ◽

Imaging Biomarkers ◽

Cardiovascular Mr ◽

Peripheral Arterial

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Can Public Health Interventions Change Immediate and Long-Term Dietary Behaviours? Encouraging Evidence from a Pilot Study of the U.K. Change4Life Sugar Swaps Campaign

Nutrients ◽

10.3390/nu14010068 ◽

2021 ◽

Vol 14 (1) ◽

pp. 68

Author(s):

Daniel J. Lamport ◽

Szu-Yun Wu ◽

Jenni Drever-Heaps ◽

Orla Hugueniot ◽

Daniel J. W. Jones ◽

...

Keyword(s):

Public Health ◽

Pilot Study ◽

Public Health Intervention ◽

Saturated Fat ◽

Small Sample ◽

Dietary Behaviour ◽

Intervention Period ◽

One Year

The aim of this pilot study was to evaluate the effectiveness of the U.K. Change4Life Sugar Swaps campaign for improving nutritional intake in a small sample of families prior to the 2015 nationwide launch. A total of 49 participants from 14 families received information and materials during a two-week intervention period in November 2014 encouraging them to swap high sugar foods and drinks for low sugar alternatives. Daily dietary intake was reported with online food diaries over four stages, each two weeks in length: (i) baseline (no information provided), (ii) intervention when Sugar Swaps materials were accessible, (iii) immediate follow-up, and (iv) one year on from baseline. Data were analysed for sugar, glucose, fructose, sucrose, lactose, fat, saturated fat, carbohydrate, protein, salt, fibre, vitamin C, and energy. During the intervention, significant daily reductions of 32 g sugar, 11 g fat, and 236 kcal for each family member were observed, among others, and 61% of benefits achieved during the intervention period were maintained at immediate follow-up. Encouragingly, for children, reductions in sugar, sucrose, fat, saturated fat, carbohydrate, and energy were observed one year on. The Sugar Swaps Campaign is potentially an effective public health intervention for improving short- and long-term dietary behaviour for the whole family.

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