Strain improvement of Rhizopus oryzae for over-production of l(+)-lactic acid and metabolic flux analysis of mutants

2004 ◽  
Vol 18 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Dong-Mei Bai ◽  
Xue-Ming Zhao ◽  
Xin-Gang Li ◽  
Shi-Min Xu
Keyword(s):  
Lactic Acid ◽  
Metabolic Flux Analysis ◽  
Metabolic Flux ◽  
Rhizopus Oryzae ◽  
Strain Improvement ◽  
Flux Analysis

Study on Temperature Regulation of Lactic Acid Bacteria Using Metabolic Flux Analysis

2011 ◽  
Vol 356-360 ◽  
pp. 127-132
Author(s):  
Xiao Jing Xiong ◽  
Yong Feng Li
Keyword(s):  
Lactic Acid ◽  
Quantitative Analysis ◽  
Lactic Acid Bacteria ◽  
Metabolic Flux Analysis ◽  
Metabolic Flux ◽  
Lactic Acid Production ◽  
Flux Analysis ◽  
Culture Temperature ◽  
Metabolic Intermediates ◽  
Fermentation Stage

Fermentation studies of lactic acid bacteria Rennanqilyf13 were performed to evaluate the potential impacts of culture temperature on cell growth and the production of L-Lactic acid. Quantitative analysis of several metabolic intermediates using metabolic flux analysis (MFA) revealed fluxes during the L-Lactic acid production from glucose. According to the metabolic flux from glucose to L-lactic acid, using different temperature at different fermentation stage maximized the concentration, yield and productivity of L-lactic acid.

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