scholarly journals The Correlation of Cyp2e1 Genetic Polymorphism on Alcohol Drinking Habits in Papuan Ethnicity

2021 ◽  
Vol 21 (2) ◽  
pp. 117-123
Author(s):  
Mardhatillah Marsa ◽  
Yudha Nurhantari ◽  
Suhartini Suhartini ◽  
Tri Ratnaningsih
Keyword(s):  
Endoplasmic Reticulum ◽  
Genetic Polymorphism ◽  
Alcohol Abuse ◽  
Alcohol Drinking ◽  
Gene Polymorphisms ◽  
Genetic Factors ◽  
Drinking Behavior ◽  
Alcohol Metabolism ◽  
Drinking Habits ◽  
The Subject

Alcohol abuse is associated with genetic factors and is influenced by certain races and ethnicities. CYP2E1, which works on the endoplasmic reticulum, produces an enzyme that plays a significant role in alcohol metabolism. In relation to it, this study aims to identify the polymorphisms of CYP2E1*5B and CYP2E1*6 genes in alcohol drinkers of Papuan Ethnics. A total of 39 Papuans were analyzed for alcohol drinking habits. Alcohol drinkers were found to be 29 people (74.4%), and 10 people (25.6%) were non-drinkers. The drinkers mainly were late teenagers (89,7%) and males (69,2%). The CYP2E1*5B genotypes were c1/c1 as 94.9% and c1/c2 as 5.1%. Meanwhile, the CYP2E1*6 T/T genotypes were 56.4%, and T/A genotypes were 43.6%. The odd ratio for CYP2E1*5B were 18,5 and 7,7 for CYP2E1*6. p0,05 for CYP2E1*5B and CYP2E1*6 gene polymorphisms for alcohol drinking behavior in the form of frequency, duration, type, and volume of alcohol consumed. Furthermore, c1/c1 and c1/c2 genotype polymorphisms were in CYP2E1*5B; T/T and T/A genotypes were in CYP2E1*6 of Papuan ethnic at Yogyakarta. In conclusion, genotype c1/c1 had 18,5 times of the possibility of being alcoholic drinkers, and genotype T/T had 7,7 times of the possibility of being alcoholic drinkers in Papuan ethnic. It indicated that the type of genotype statistically did not significantly affect alcohol drinking behavior on the subject.

Alcohol Drinking Habits and Genetic Polymorphism of Alcohol Metabolism Genes in West Siberia

2001 ◽  
Vol 1 (3) ◽  
pp. 165-171 ◽  
Author(s):  
Anna Belkovets ◽  
S. Kurilovich ◽  
A. Avkenstyuk ◽  
Dharam P. Agarwal
Keyword(s):  
Genetic Polymorphism ◽  
Alcohol Drinking ◽  
West Siberia ◽  
Alcohol Metabolism ◽  
Drinking Habits

Effect of the Covid-19 Italian lockdown on human health: the analysis of alcohol consumption for aware quarantine (Preprint)

2020 ◽  
Author(s):  
Chiara Mazzarella ◽  
Annamaria Spina ◽  
Marcello Dallio ◽  
Antonietta Gerarda Gravina ◽  
Mario Romeo ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Abuse ◽  
Psychosocial Factors ◽  
Alcohol Drinking ◽  
Psychosocial Support ◽  
Human Life ◽  
Stressful Event ◽  
Drinking Behaviour ◽  
Drinking Habits ◽  
Specific Subset

BACKGROUND Italy has been one of the first western countries seriously involved in the COVID-19 pandemic in the first months of 2020 and so that the national government was forced to impose a long lockdown period, stopping all the people aggregation outdoor and indoor activities. From a social point of view this period of domestic confinement resulted in deep changes of behaviours and lifestyles, promoting in many people the onset of psychological symptoms and signs (including anxiety, depression, insomnia, and irritability among others) already known as associated with drug and alcohol abuse OBJECTIVE this study aims to assess the variation of alcohol drinking habits in a sample of Italian citizens during the COVID-19 lockdown and to identify the psychosocial factors surrounding it, in order to assess the specific subset of the population that could need psychosocial support during these events METHODS An online anonymous questionnaire was created and submitted from 9th April 2020 to 28th April 2020 using social medias and e-mails. Questions were related to personal details such as age, work, instruction, and, moreover, to alcohol drinking habits during the lockdown, including Alcohol Use Disorders Identification Test (AUDIT C) test questions RESULTS A total of 1234 surveys were filled out by subjects with an age range from 18 to 80 years old. An increase in both anxiety and fear has been detected in most of the participants (63% and 61% respectively) with a direct (r=0.652; p<0.001) relationship between them. Participants older than 50 years showed the strongest correlation between alcohol consumption, fear, and anxiety, (r=0.830, P <0.001 and r=0.741, P<0.001, respectively). Subjects living alone experienced a stronger association between anxiety, fear, and higher level of alcohol consumption (r: 0.529; P<0.001; r: 0.628, P<0.001 respectively). Moreover, 18% of participants increased alcohol consumption drinking during the lockdown. These subjects showed a lower frequency of alcohol consumption before the lockdown in comparison to the rest of the study population (2.5±0.96 vs 3±1.03, P<0.0001 respectively). Moreover, comparing the abovementioned groups, the percentage of subjects who experienced higher alcohol assumption before the 11th of March was higher in those that didn't change their drinking behaviour during the lockdown in comparison to that portion of them that experienced a worsening of alcohol abuse (r: 30.422, P<0.0001) CONCLUSIONS according to these data, during the Italian lockdown due to COVID 19 pandemic, different kind of people experienced an increase in alcohol drinking. Several psychosocial factors are involved in determining the increase in harmful alcohol consumption during this extraordinary stressful event and they must be addressed by the healthcare support in order to avoid awful lockdown impact on human life

Effects of ALDH2 gene polymorphisms and alcohol-drinking behavior on micronuclei frequency in non-smokers

2003 ◽  
Vol 541 (1-2) ◽  
pp. 71-80 ◽  
Author(s):  
Hitoshi Ishikawa ◽  
Hidetaka Yamamoto ◽  
Ying Tian ◽  
Mitsuo Kawano ◽  
Toru Yamauchi ◽  
...  
Keyword(s):  
Alcohol Drinking ◽  
Gene Polymorphisms ◽  
Drinking Behavior ◽  
Aldh2 Gene

scholarly journals Genetic polymorphism of ALDH2 linkage to kidney function status of East Nusa Tenggara alcohol drinkers and cigarette smokers

2021 ◽  
Vol 4 (2) ◽  
pp. 118
Author(s):  
Busyra Busyra ◽  
Yudha Nurhantari ◽  
Suhartini Suhartini ◽  
Maria Agnes Etty Dedy ◽  
Tri Ratnaningsih
Keyword(s):  
Chronic Kidney Disease ◽  
Genetic Polymorphism ◽  
Kidney Disease ◽  
Cigarette Smoking ◽  
Kidney Function ◽  
Alcohol Drinking ◽  
Dna Analysis ◽  
Drinking Behavior ◽  
Smoking Habits ◽  
Cigarette Smokers

Chronic kidney disease is a preventable high-burden disease. Several risk factors for impaired kidney function have been identified, including lifestyles, such as alcohol drinking and cigarette smoking. However, the evidence remains inconsistent. East Nusa Tenggara has the largest proportion of heavy alcohol drinking among all provinces in Indonesia. Genetic polymorphism of aldehyde dehydrogenase 2 (ALDH2) is related to alcohol drinking behavior through the inactivity of the ALDH2 enzyme, which leads to toxic acetaldehyde accumulation. This study aims to recognize the linkage of ALDH2 genotypes to kidney function among alcohol drinkers and cigarette smokers in East Nusa Tenggara. This study was a cross-sectional study of East Nusa Tenggara ethnicity, aged 18-60 years old. Demographic and lifestyle data were obtained via a questionnaire. DNA analysis was conducted with the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Creatinine and BUN levels were measured with a chemistry analyzer. Afterward, the estimated glomerular filtration rate (eGFR) was calculated from creatinine value using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. The association between kidney function status and alcohol drinking and cigarette smoking habits were analyzed using the chi-square test, then stratified based on genotype groups. Fifty-one subjects were included in this study, while the mean age was 26.33±1.33 years and the median age was 22 years. There were 37 (72.5%) alcohol drinkers and 14 (27.5%) non-drinkers; 28 (54,9%) cigarette smokers and 23 (45.1%) non-smokers. This study revealed no significant association between kidney function status and alcohol drinking habits. Cigarette smoking habits were inversely associated with eGFR decline and creatinine elevation in wild-type ALDH2 groups.

scholarly journals KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

2016 ◽  
Vol 113 (50) ◽  
pp. 14372-14377 ◽  
Author(s):  
Gunter Schumann ◽  
Chunyu Liu ◽  
Paul O’Reilly ◽  
He Gao ◽  
Parkyong Song ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Drinking ◽  
Drinking Behavior ◽  
Public Health Problem ◽  
Alcohol Preference ◽  
European Ancestry ◽  
Major Public Health Problem ◽  
Excessive Alcohol Consumption ◽  
Drinking Habits ◽  
A Genome

Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a genome-wide association metaanalysis and replication study among >105,000 individuals of European ancestry and identified β-Klotho (KLB) as a locus associated with alcohol consumption (rs11940694; P = 9.2 × 10−12). β-Klotho is an obligate coreceptor for the hormone FGF21, which is secreted from the liver and implicated in macronutrient preference in humans. We show that brain-specific β-Klotho KO mice have an increased alcohol preference and that FGF21 inhibits alcohol drinking by acting on the brain. These data suggest that a liver–brain endocrine axis may play an important role in the regulation of alcohol drinking behavior and provide a unique pharmacologic target for reducing alcohol consumption.

Golgi Apparatus and Melanogenesis: Ultrastructural Study of a Human Cellular Blue Nevus (Melanocytoma)

1973 ◽  
Vol 31 ◽  
pp. 380-381
Author(s):  
S.R. Allegra
Keyword(s):  
Endoplasmic Reticulum ◽  
Golgi Apparatus ◽  
Ultrastructural Study ◽  
The Other ◽  
Blue Nevus ◽  
Normal Complement ◽  
Golgi Vesicles ◽  
Golgi System ◽  
The Subject ◽  
Cellular Blue Nevus

The respective roles of the ribo somes, endoplasmic reticulum, Golgi apparatus and perhaps nucleus in the synthesis and maturation of melanosomes is still the subject of some controversy. While the early melanosomes (premelanosomes) have been frequently demonstrated to originate as Golgi vesicles, it is undeniable that these structures can be formed in cells in which Golgi system is not found. This report was prompted by the findings in an essentially amelanotic human cellular blue nevus (melanocytoma) of two distinct lines of melanocytes one of which was devoid of any trace of Golgi apparatus while the other had normal complement of this organelle.

Exploring the Nexus between Online Alcohol Posters and Alcohol Drinking among Kenya’s Higher Vocational College students

2020 ◽  
Author(s):  
Joseph Malechwanzi
Keyword(s):  
Public Health ◽  
College Students ◽  
Social Media ◽  
Substance Abuse ◽  
Alcohol Drinking ◽  
Alcoholic Beverage ◽  
Vocational College ◽  
Drinking Habits ◽  
Higher Vocational College ◽  
Unrestricted Access

Alcohol drinking among young people is a major global public health concern. The situation has been aggravated further by the advent of the internet and subsequent development of social media as a tool for online alcohol marketing. Measures that aim at reducing substance abuse is a stride towards “2030 Agenda” for sustainable development goal number 3 set by the United Nation General Assembly. In this goal, attention is not only drawn to health and wellbeing but also to prevention and treatment of substance abuse. This descriptive study sought to find out the prevalence of alcohol advertisements on social media and its possible influence on alcohol drinking among Kenya’s higher vocational college students. Based on a field survey conducted in Nairobi (n=209), this study established that there was heavy presence of alcohol advertisements on social media scene in Kenya. Although statistically, there was huge gender disparity, the final results showed that there was significant association between alcohol ads on social media and college student’s possible alcohol drinking habits. This study concludes that there was heavy presence of alcohol ads on social media, and the likelihood of youth having unrestricted access to the alcoholic beverage products. This could have a far-reaching implication on their alcohol drinking habits. Therefore, the study recommends the stakeholders in public health promotions to formulate policies aimed at mitigating against the challenges posed by unrestricted access to online alcohol ads by the youth in order to prevent them from being lured into early alcohol drinking by the alcoholic beverage makers.　 Keywords: Alcohol abuse; Influence; Online ads; Youth; Kenya

Rethinking the Alcohol Problem: A Natural Processes Model

1984 ◽  
Vol 14 (1) ◽  
pp. 31-43 ◽  
Author(s):  
Harold A. Mulford
Keyword(s):  
Alcohol Use ◽  
Alcohol Abuse ◽  
Drinking Behavior ◽  
Alcohol Problem ◽  
Social Psychological ◽  
Rehabilitation Process ◽  
Natural Processes ◽  
Traditional Notion ◽  
Way Of Thinking ◽  
Single Set

A multivariate natural processes model for thinking about alcohol use and abuse is offered as an alternative to the traditional static-entity, single-cause way of thinking that historically generated a series of formal institutional attacks on different supposed causes of alcohol abuse, but which failed to solve the alcohol problem. The work seeks a model that better fits what is known about the alcohol problem, and one that leads to more effective informal constraints on alcohol abuse. Alcoholics are viewed as being at some stage of an alcoholic process, a rehabilitation process, a labeling process, a clinicalization process and a dissocialization process. This way of thinking challenges the traditional notion that alcoholics are all-of-a-kind entities and that there is a single cause, or even a single set of causes, that account for the drinking of all alcoholics, or that explains the drinking of the same person at different times. Rather, it directs us to consider the dynamics of the changing combinations of interacting social, psychological and physiological forces influencing a person's drinking behavior as he progresses in the several processes.

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