Production of Secondary Metabolites by Solid-State Fermentation

1996 ◽  
pp. 85-121 ◽  
Author(s):  
Javier Barrios-González ◽  
Armando Mejía
2021 ◽  
Vol 59 (1) ◽  
pp. 1
Author(s):  
Doan Thi Mai Huong

In a recent study, we described two new lavandulylated flavonoids, along with eight known compounds from the culture broth of a Streptomyces sp. (strain G246), isolated from the sponge Halichondria panicea, collected in the sea of Son Tra peninsula (Da Nang). A comparison study was conducted to differentiate between solid and liquid fermentation technique for secondary metabolites production of strain G246. In this paper, we report the isolation and structural characterization of 9 secondary metabolites (1-9) from strain G246 by solid state fermentation. Compound 3 was the only one similarity between these fermentation techniques.


2020 ◽  
pp. 124566
Author(s):  
Vinod Kumar ◽  
Vivek Ahluwalia ◽  
Saurabh Saran ◽  
Jitendra Kumar ◽  
Anil Kumar Patel ◽  
...  

2017 ◽  
Vol 27 (1) ◽  
pp. 107-113 ◽  
Author(s):  
Ozana Almeida Lessa ◽  
Nadabe dos Santos Reis ◽  
Selma Gomes Ferreira Leite ◽  
Melissa Limoeiro Estrada Gutarra ◽  
Alexilda Oliveira Souza ◽  
...  

Fermentation ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. 247
Author(s):  
Andi Setiawan ◽  
Widyastuti Widyastuti ◽  
Arik Irawan ◽  
Oklis Syahrin Wijaya ◽  
Aspita Laila ◽  
...  

Marine actinomycetes are prolific microorganisms; however, knowledge of their diversity, distribution, and secondary metabolites is limited. Marine actinomycetes represent an untapped source of novel bioactive compounds. In this study, we investigated shrimp shell as substrates for model production bioactive metabolites from actinomycetes under solid state fermentation (SSF) conditions. A total of fifteen actinomycetes were isolated from six sponges and one tunicate. The isolated actinomycetes were grown on solid shrimp shells. Cultures of actinomycetes were extracted with ethyl acetate (EtOAc) and extracts were bioassayed for activity against Staphylococcus aureus. One isolate 18A13O1 from the sponge, Rhabdastrella globostellata, exhibited antibacterial activity on primary screening compared to the other samples and was chosen for further study. Visualization using SEM showed aerial and substrate mycelia. Through phylogenetic analysis, it was confirmed that isolate 18A13O1 is a Pseudonocardia carboxydivorans. Purification of an EtOAc extract yielded A13B2, which showed a minimum inhibition concentration against S. aureus at 15.6 μg/mL. It can be concluded that this basic information is very important for further studies related to the development of the production of bioactive secondary metabolites through the solid state fermentation process.


2020 ◽  
Vol 6 (3) ◽  
pp. 137
Author(s):  
Diego Ibarra-Cantún ◽  
María Elena Ramos-Cassellis ◽  
Marco Antonio Marín-Castro ◽  
Rosalía del Carmen Castelán-Vega

Solid-state fermentation (SSF) is used in enzyme and antibiotic production, bioethanol and biodiesel as an alternative energy source, biosurfactants with environmental goals, and the production of organic acids and bioactive compounds. The present project determined the quantity of secondary metabolites and the antioxidant activity of the extracts obtained by the solid-state fermentation of apple and agave mezcalero bagasse over 28 days, inoculated with the Pleurotus ostreatus strain. The extraction was carried out with three solvents: acetone and water (80:20 v/v), 100% methanol and 100% water. The results showed a higher presence of phenolic compounds, flavonoids, total triterpenes and antioxidant activity in the apple bagasse from the SSF on day 21 in the extract of acetone and water (80:20 v/v), 100% methanol and aqueous; while the agave bagasse showed a significant presence of phenolic compounds and flavonoids only in the aqueous extract. In conclusion, the presence of secondary metabolites exhibiting antioxidant activities from the solid-state fermentation in the residues of the cider and mezcal industry is an alternative use for wasted raw material, plus, it reduces the pollution generated from the agroindustrial residues.


Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
G Juodeikiene ◽  
D Cizeikiene ◽  
A Maruška ◽  
E Bartkiene ◽  
L Basinskiene ◽  
...  

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