Green Hydrogen Catapult targets 50-fold global production scale-up in next six years

2020 ◽  
Vol 2020 (12) ◽  
pp. 1
Keyword(s):  
Scale Up ◽  
Production Scale

scholarly journals Nanotechnology in Personalized Medicine: A Promising Tool for Alzheimer’s Disease Treatment

2018 ◽  
Vol 25 (35) ◽  
pp. 4602-4615 ◽  
Author(s):  
Laura De Matteis ◽  
Rafael Martín-Rapún ◽  
Jesús M. de la Fuente
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Personalized Medicine ◽  
Adverse Effects ◽  
Metabolic Response ◽  
Scale Up ◽  
High Sensitivity ◽  
Production Scale ◽  
Patient Response ◽  
Detection Techniques

Background: Alzheimer’s disease (AD) is a public health priority all over the world. The difficulty of fighting the disease consists mostly in the complexity of symptoms and causes, in the still poor knowledge of its mechanisms and in the existence of a latent, asymptomatic, preclinical stage. Although many drugs are continuously screened in clinical studies for the treatment of Alzheimer’s disease, the unexpected lack of patient response and sometimes the important adverse effects make it a potential field of application for personalized medicine. Objective: This perspective review proposes nanotechnology as a valuable tool for the application of personalized medicine to AD. Methods: The aim of personalized medicine is the development of more patient-precise treatments based mostly on the knowledge of individual genetics as well as of disease progress, and of pharmacokinetics and metabolic response to available drugs. The optimization of new and more sensitive detection techniques is an important tool for obtaining the pool of data needed for prediction and understanding of patient response. Results: Research in bionanosensors is already providing examples with high sensitivity for core and new biomarkers for AD. In therapy the functionalization of nanoparticle surface can add specificity for biological recognition or for improving the bioavailability. This would allow the administration of lower doses with less adverse effects due to the local targeting. Conclusion: Taking into account the promising characteristics of nanoparticles as excellent candidate tools for precision medicine development, the establishment of better standard methods for safety assessment and production scale up would be desirable for the nanomaterial fruitful employment.

Scale-up of Process Intensifying Falling Film Microreactors to Pilot Production Scale

2007 ◽  
Vol 5 (1) ◽  
Author(s):  
Bhanu Kiran Vankayala ◽  
Patrick Löb ◽  
Volker Hessel ◽  
Gabriele Menges ◽  
Christian Hofmann ◽  
...  
Keyword(s):  
Sodium Hydroxide Solution ◽  
Ambient Pressure ◽  
Scale Up ◽  
Process Intensification ◽  
Aqueous Sodium Hydroxide ◽  
Liquid Films ◽  
Process Conditions ◽  
Falling Film ◽  
Production Scale ◽  
Future Production

Microstructured reactors with their benefits especially concerning enhanced mass and heat transfer represent a means for process intensification. A broadly used microstructured lab tool in the area of gas/liquid contacting is the Falling Film Microreactor (FFMR) developed by IMM in which liquid films of a few tens of micrometer thickness and interfacial areas of up to 20,000 m2/m3 combined with an effective heat exchange can be obtained. Now the concept of the Falling Film Microreactor has been developed further with regard to increasing throughput in order to reach pilot production level and as a basis for future production scale throughput. Therefore, two different prototypes with a tenfold larger structured surface area have been developed and realized. The feasibility of a corresponding increase of throughput has been demonstrated for the oxidation of an organic compound using oxygen which is closely linked to an industrial relevant reaction and additionally by the absorption of CO2 in an aqueous sodium hydroxide solution. Naturally, process optimisation itself also contributes to the efforts to increase throughput. Therefore, the oxidation reaction has been optimised in both varying process parameters (temperature, flow rates, pressure) and reactor parameters (microchannel width and depth) in the original, standard Falling Film Microreactor. Conducting experiments at 10 bar instead of ambient pressure and using a reaction plate with 1200 µm x 400 µm channels instead of 600 µm x 200 µm channels lead to an increase in conversion. These investigations also encourage exploring more challenging process conditions and thereby following the concept of "novel chemistry."

scholarly journals Policy Lessons From Medical Responses to the COVID-19 Crisis

2021 ◽  
Vol 56 (6) ◽  
pp. 337-340
Author(s):  
Giovanni Dosi
Keyword(s):  
Political Economy ◽  
Ad Hoc ◽  
Scale Up ◽  
Basic Research ◽  
Basic Knowledge ◽  
Production Scale ◽  
International Protection ◽  
Non Profit ◽  
Research Production ◽  
Public Money

AbstractThis article discusses the medical/therapeutical responses to the COVID-19 pandemic and their political economy context. First, the very quick development of several vaccines highlights the richness of the basic knowledge waiting for therapeutical exploitation. Such knowledge has largely originated in public or non-profit institutions. Second, symmetrically, there is longer-term evidence that the private sector (essentially big pharma) has decreased its investment in basic research in general and has long been uninterested in vaccines in particular. Only when flooded with an enormous amount of public money did it become eager to undertake applied research, production scale-up and testing. Third, the political economy of the underlying public-private relationship reveals a profound dysfunctionality with the public being unable to determine the rates and direction of innovation, but at the same time confined to the role of payer of first and last resort, with dire consequences for both advanced, and more so developing countries. Fourth, on normative grounds, measures like ad hoc patent waivers are certainly welcome, but this will not address the fundamental challenge, involving a deep reform of the intellectual property rights regimes and their international protection.

scholarly journals Design of a Thorium Metal Target for 225Ac Production at TRIUMF

Instruments ◽  
2019 ◽  
Vol 3 (1) ◽  
pp. 18 ◽  
Author(s):  
Andrew Robertson ◽  
Andrew Lobbezoo ◽  
Louis Moskven ◽  
Paul Schaffer ◽  
Cornelia Hoehr
Keyword(s):  
Proton Beam ◽  
Scale Up ◽  
Clinical Results ◽  
Target System ◽  
Average Standard Deviation ◽  
Production Scale ◽  
Alpha Therapy ◽  
Mev Protons ◽  
Production Target ◽  
Significant Effort

With recent impressive clinical results of targeted alpha therapy using 225Ac, significant effort has been directed towards providing a reliable and sufficient supply of 225Ac to enable widespread using of 225Ac-radiopharmaceuticals. TRIUMF has begun production of 225Ac via spallation of thorium metal with 480 MeV protons. As part of this program, a new 225Ac-production target system capable of withstanding the power deposited by the proton beam was designed and its performance simulated over a range of potential operating parameters. Special attention was given to heat transfer and stresses within the target components. The target was successfully tested in two irradiations with a 72–73 µA proton beam for a duration of 36.5 h. The decay corrected activity at end of irradiation (average ± standard deviation) was (524 ± 21) MBq (14.2 mCi) and (86 ± 13) MBq (2.3 mCi) for 225Ac and 225Ra, respectively. These correspond to saturation yields of 72.5 MBq/µA for 225Ac and 17.6 MBq/µA for 225Ra. Longer irradiations and production scale-up are planned in the future.

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