Abstract # P-17: Association of NQO1 (Rs1800566) Polymorphism with NQO1 Levels and Risk of Diabetic Nephropathy in Indian Population

2016 ◽  
Vol 22 ◽  
pp. 21
Author(s):  
Mohini Sharma ◽  
S. Gupta ◽  
M. Mehndiratta ◽  
O.P. Kalra ◽  
R. Shukla ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Indian Population

scholarly journals Role of eNOS and TGFβ1 gene polymorphisms in the development of diabetic nephropathy in type 2 diabetic patients in South Indian population

2022 ◽  
Vol 23 (1) ◽  
Author(s):  
Sindhu Varghese ◽  
Subbaraj Gowtham Kumar
Keyword(s):  
Diabetic Nephropathy ◽  
Genetic Variants ◽  
Gene Polymorphisms ◽  
Indian Population ◽  
Diabetic Patients ◽  
South Indian Population ◽  
Type 2 Diabetic Patients ◽  
South Indian ◽  
Type 2 Diabetic

Abstract Background Diabetic nephropathy is known to be a leading complication of diabetes mellitus, characterized by diverse aspects such as high urinary albumin level, elevated blood pressure, and genetic susceptibility leading to end-stage renal disease. The current study was carried out to investigate the association of eNOS and TGFβ1 gene polymorphisms in the progression of diabetic nephropathy among type 2 diabetic patients in the South Indian population. The eNOS and TGFβ1 genetic variants were genotyped in 280 T2DM patients, 140 with DN, 140 without DN, and 140 controls. Genotyping was performed using ARMS PCR and the genomic variants were confirmed by the Sanger sequencing method. Results A significant (p < 0.05) association was observed in the genotypic frequencies of eNOS (G > T) polymorphism in the T2DM patients with diabetic nephropathy when compared to controls. The frequency of TT (heterozygous) genotype was observed to increase in patients with type 2 diabetes and DN when compared to the diabetic patients without DN and controls. This indicates that diabetic patients with TT genotype are at an increased risk to develop DN. However, TGFβ1 (G > C) polymorphism did not show any association in the allele and genotypic frequencies with DN when compared with T2DM and controls. Conclusion The results of the study propose a strong influence of TT genotype of eNOS gene be significantly linked with diabetic nephropathy in T2DM patients. Whereas no association was examined concerning TGFβ1 gene polymorphism and DN. Nevertheless, large sample size studies are required to confirm the part of these genetic variants in the development of DN.

Association of the PPARGC1A Gene Polymorphism With Diabetic Nephropathy in an Asian Indian Population (CURES-41)

2010 ◽  
Vol 8 (2) ◽  
pp. 119-126 ◽  
Author(s):  
Sakthi Baby Gayathri ◽  
Venkatesan Radha ◽  
Karani S. Vimaleswaran ◽  
Viswanathan Mohan
Keyword(s):  
Diabetic Nephropathy ◽  
Gene Polymorphism ◽  
Asian Indian ◽  
Indian Population ◽  
Asian Indian Population

scholarly journals Role of the ACE ID and PPARG P12A Polymorphisms in Genetic Susceptibility of Diabetic Nephropathy in a South Indian Population

2013 ◽  
Vol 5 (3) ◽  
pp. 813-7 ◽  
Author(s):  
Lakkakula VKS Bhaskar ◽  
Sultana Mahin ◽  
Raju Thankabai Ginila ◽  
Periyasamy Soundararajan
Keyword(s):  
Diabetic Nephropathy ◽  
Genetic Susceptibility ◽  
Indian Population ◽  
South Indian Population ◽  
South Indian

scholarly journals Prevalence and Risk Factors of Diabetic Nephropathy in an Urban South Indian Population: The Chennai Urban Rural Epidemiology Study (CURES 45)

Diabetes Care ◽  
2007 ◽  
Vol 30 (8) ◽  
pp. 2019-2024 ◽  
Author(s):  
R. Unnikrishnan ◽  
M. Rema ◽  
R. Pradeepa ◽  
M. Deepa ◽  
C. S. Shanthirani ◽  
...  
Keyword(s):  
Risk Factors ◽  
Diabetic Nephropathy ◽  
Indian Population ◽  
South Indian Population ◽  
Epidemiology Study ◽  
South Indian ◽  
Urban South ◽  
Urban Rural

scholarly journals Association of Genetic Variants of ELMO1 Gene With Diabetic Nephropathy in the North Indian Population

2020 ◽  
Author(s):  
Gurvinder Singh ◽  
Rubina Sharma ◽  
Priyanka Raina ◽  
Vishali Kalotra ◽  
Harkirat Sandhu ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Physical Inactivity ◽  
Indian Population ◽  
Linkage Disequilibrium Mapping ◽  
North Indian Population ◽  
The North ◽  
High Doses ◽  
Stage Renal Disease ◽  
End Stage

Abstract Diabetic nephropathy (DN) is a major cause of renal failure globally including chronic kidney disease and end-stage renal disease (ESRD). Using comprehensive linkage disequilibrium mapping, we genotyped five polymorphisms from engulfment and cell motility 1 (ELMO1) gene (rs741301, rs7799004, rs1882080, rs11769038 and rs1345365) to evaluate its association with DN. BMI was observed to be low in DN cases as compared to the control groups, which is the result of haemodialysis and high doses of medication. Physical inactivity, lipid profile, urea and creatinine were observed to be the confounding factors correlated with DN. This study comprehensively evaluated ELMO1 in DN patients, T2D without Nephropathy and healthy controls from North Indian population and revealed significant association with DN. Haplotypes G-G-C-C and G-A-T-T provided ~2-fold risk towards DN development. In conclusion, the present study suggests the significant role of ELMO1 gene polymorphisms in the pathophysiology of DN in North-Indian population.

Association of rs11643718SLC12A3and rs741301ELMO1Variants with Diabetic Nephropathy in South Indian Population

2016 ◽  
Vol 80 (6) ◽  
pp. 336-341 ◽  
Author(s):  
Dhanasekaran Bodhini ◽  
Manickam Chidambaram ◽  
Samuel Liju ◽  
Balakannan Revathi ◽  
Dhandapani Laasya ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Indian Population ◽  
South Indian Population ◽  
South Indian

scholarly journals Association of A1538G and C2437T single nucleotide polymorphisms in heat shock protein-70 genes with diabetic nephropathy among South Indian population

2017 ◽  
Vol 37 (2) ◽  
Author(s):  
Umapathy Dhamodharan ◽  
Krishnamoorthy Ezhilarasi ◽  
Balashanmugam Ponjayanthi ◽  
Dornadula Sireesh ◽  
Kunka Mohanram Ramkumar ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Heat Shock ◽  
Indian Population ◽  
Clinical Symptoms ◽  
Control Group ◽  
South Indian Population ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
South Indian ◽  
Stage Renal Disease

Diabetic Nephropathy (DN) is the leading cause of end-stage renal disease, characterized by progressive albuminuria and conferring additional risk of cardiovascular disease (CVD) and mortality. The crucial role of heat-shock proteins (HSPs) on renal function in patients with DN has been well documented. The present study was aimed to understand the association of HSP-70 gene variants on the susceptibility of Type 2 Diabetes Mellitus (T2DM) and DN. A total of 946 subjects (549 Males; 397 Females) were recruited and divided into four groups according to the levels of urinary albumin excretion (UAE): those with normoalbuminuria (UAE <30 mg/24 h; n=230), those with microalbuminuria (30≤ UAE ≤300 mg/24 h; n=230), and those with macroalbuminuria (UAE> 300 mg/24 h; n=230). The control group randomly enrolled a consecutive population of 256 healthy subjects who had a routine medical check-up in our hospital. Those subjects had no history or clinical symptoms of diabetes. Subjects were genotyped for HSP70-2 (+1538 A/G; rs2763979) and HSP70-hom (+2437 C/T; rs2227956) by PCR-restriction fragment length polymorphism (RFLP). The ‘G’ allele of HSP70-2 (+1538 A/G) single nucleotide polymorphism (SNP) showed relative risk for normoalbuminuria, microalbuminuria and macroalbuminuria subjects whereas the ‘T’ allele of HSP70-hom (+2437 C/T) SNP showed significant protection against macroalbuminuria subjects. In conclusion, our results indicate that the HSP70-2 (+1538 A/G) and HSP70-hom (+2437 C/T) SNPs are highly associated with renal complications in T2DM among the South Indian population.

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