624 Improved ventilatory performance at submaximal effort following exercise training in severe CHF patients is independent of improvement in maximal aerobic capacity

Long-term rehabilitative strategies are important for individuals with well-healed burn injuries. Such information is particularly critical because patients are routinely surviving severe burn injuries given medical advances in the acute care setting. The purpose of this study was to test the hypothesis that a 6-mo community-based exercise training program will increase maximal aerobic capacity (V̇o2max) in subjects with prior burn injuries, with the extent of that increase influenced by the severity of the burn injury (i.e., percent body surface area burned). Maximal aerobic capacity (indirect calorimetry) and skeletal muscle oxidative enzyme activity (biopsy of the vastus lateralis muscle) were measured pre- and postexercise training in noninjured control subjects ( n = 11) and in individuals with well-healed burn injuries ( n = 13, moderate body surface area burned; n = 20, high body surface area burned). Exercise training increased V̇o2max in all groups (control: 15 ± 5%; moderate body surface area: 11 ± 3%; high body surface area: 11 ± 2%; P < 0.05), though the magnitude of this improvement did not differ between groups ( P = 0.7). Exercise training also increased the activity of the skeletal muscle oxidative enzymes citrate synthase ( P < 0.05) and cytochrome c oxidase ( P < 0.05), an effect that did not differ between groups ( P = 0.2). These data suggest that 6 mo of progressive exercise training improves V̇o2max in individuals with burn injuries and that the magnitude of body surface area burned does not lessen this adaptive response.

Download Full-text

Using Molecular Classification to Predict Gains in Maximal Aerobic Capacity Following Endurance Exercise Training in Humans

Current Cardiovascular Risk Reports ◽

10.1007/s12170-010-0121-9 ◽

2010 ◽

Vol 4 (5) ◽

pp. 319-320

Author(s):

Vaughn W. Barry ◽

Timothy Church ◽

Steven N. Blair

Keyword(s):

Exercise Training ◽

Endurance Exercise ◽

Aerobic Capacity ◽

Molecular Classification ◽

Maximal Aerobic Capacity ◽

Endurance Exercise Training

Download Full-text

Influence of angiotensinogen and angiotensin-converting enzyme polymorphisms on cardiac hypertrophy and improvement on maximal aerobic capacity caused by exercise training

European Journal of Cardiovascular Prevention & Rehabilitation ◽

10.1097/hjr.0b013e32832c5a8a ◽

2009 ◽

Vol 16 (4) ◽

pp. 487-492 ◽

Cited By ~ 10

Author(s):

Guilherme B. Alves ◽

Edilamar M. Oliveira ◽

Cleber R. Alves ◽

Heron R.S. Rached ◽

Glória F.A. Mota ◽

...

Keyword(s):

Exercise Training ◽

Physical Exercise ◽

Angiotensin Converting Enzyme ◽

Aerobic Capacity ◽

Ventricular Hypertrophy ◽

Cardiopulmonary Exercise Test ◽

Left Ventricular ◽

Converting Enzyme ◽

Maximal Aerobic Capacity

Background The allele threonine (T) of the angiotensinogen has been associated with ventricular hypertrophy in hypertensive patients and soccer players. However, the long-term effect of physical exercise in healthy athletes carrying the T allele remains unknown. We investigated the influence of methionine (M) or T allele of the angiotensinogen and D or I allele of the angiotensin-converting enzyme on left-ventricular mass index (LVMI) and maximal aerobic capacity in young healthy individuals after long-term physical exercise training. Design Prospective clinical trial. Methods Eighty-three policemen aged between 20 and 35 years (mean ± SD 26 ± 4.5 years) were genotyped for the M235T gene angiotensinogen polymorphism (TT, n = 25; MM/MT, n = 58) and angiotensin-converting enzyme gene insertion/deletion (I/D) polymorphism (II, n = 18; DD/DI, n = 65). Left-ventricular morphology was evaluated by echocardiography and maximal aerobic capacity (VO2peak) by cardiopulmonary exercise test before and after 17 weeks of exercise training (50–80% VO2peak). Results Baseline VO2peak and LVMI were similar between TT and MM/MT groups, and II and DD/DI groups. Exercise training increased significantly and similarly VO2peak in homozygous TT and MM/MT individuals, and homozygous II and DD/DI individuals. In addition, exercise training increased significantly LVMI in TT and MM/MT individuals (76.5 ± 3 vs. 86.7 ± 4, P = 0.00001 and 76.2 ± 2 vs. 81.4 ± 2, P = 0.00001, respectively), and II and DD/DI individuals (77.7 ± 4 vs. 81.5 ± 4, P = 0.0001 and 76 ± 2 vs. 83.5 ± 2, P = 0.0001, respectively). However, LVMI in TT individuals was significantly greater than in MM/MT individuals ( P = 0.04). LVMI was not different between II and DD/DI individuals. Conclusion Left-ventricular hypertrophy caused by exercise training is exacerbated in homozygous TT individuals with angiotensinogen polymorphism.

Download Full-text

Exercise Strategies for Optimizing Aerobic Capacity and Skeletal Muscle Performance in Older Adults

Innovation in Aging ◽

10.1093/geroni/igaa057.1703 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

pp. 528-528

Author(s):

Dallin Tavoian ◽

David Russ ◽

Brian Clark

Keyword(s):

Older Adults ◽

Lower Extremity ◽

Aerobic Capacity ◽

Muscle Performance ◽

Moderate Intensity ◽

Continuous Training ◽

Maximal Aerobic Capacity ◽

Comparable Amount ◽

Supervised Exercise ◽

Type Of Exercise

Abstract Most older adults do not exercise regularly. Among those who do, the majority only perform one type of exercise, and— as such— are either not getting the benefits of endurance exercise or resistance exercise. The aim of this pilot study was to determine which standalone exercise strategy has the greatest effect on both cardiorespiratory and lower-extremity muscular function in insufficiently active older adults 60 to 75 years of age (N = 14). Participants were randomly assigned to either resistance training (RT, n=5), moderate intensity continuous training on a stationary bicycle (MICT, n=4), or high-intensity interval training on a stationary bicycle (HIIT, n=5) for supervised exercise sessions three times per week for 12 weeks. Maximal oxygen consumption increased a comparable amount in all groups (11.9±11.2% for HIIT vs. 8.0±14.8% for MICT vs 9.8±5.7% for RT). Leg extensor power did not change in the HIIT group (-0.34±5.2%), but increased by 5.2±9.7% in the MICT group and 14.5±26.1% in the RT group. Leg extensor strength decreased by 1.7±22.1% in the HIIT group and 0.6±6.4% in the MICT group, but increased by 27.3±21.2% in the RT group. These findings demonstrate that RT results in improved lower-extremity strength and power, as well as improvements in maximal aerobic capacity comparable to MICT and HIIT in older adults. Thus, RT should be promoted as an essential exercise strategy for older adults, particularly for individuals who are inactive or that are only performing one type of exercise regularly.

Download Full-text

Omega-3 fatty acid blood levels are inversely associated with cardiometabolic risk factors in HFpEF patients: the Aldo-DHF randomized controlled trial

Clinical Research in Cardiology ◽

10.1007/s00392-021-01925-9 ◽

2021 ◽

Author(s):

Katharina Lechner ◽

Johannes Scherr ◽

Elke Lorenz ◽

Benjamin Lechner ◽

Bernhard Haller ◽

...

Keyword(s):

Fatty Acid ◽

Aerobic Capacity ◽

Cardiometabolic Risk ◽

Left Ventricular Diastolic Function ◽

Left Ventricular ◽

Blood Levels ◽

Omega 3 ◽

Maximal Aerobic Capacity ◽

Omega 3 Fatty Acid ◽

Neurohumoral Activation

Abstract Objectives To evaluate associations of omega-3 fatty acid (O3-FA) blood levels with cardiometabolic risk markers, functional capacity and cardiac function/morphology in patients with heart failure with preserved ejection fraction (HFpEF). Background O3-FA have been linked to reduced risk for HF and associated phenotypic traits in experimental/clinical studies. Methods This is a cross-sectional analysis of data from the Aldo-DHF-RCT. From 422 patients, the omega-3-index (O3I = EPA + DHA) was analyzed at baseline in n = 404 using the HS-Omega-3-Index® methodology. Patient characteristics were; 67 ± 8 years, 53% female, NYHA II/III (87/13%), ejection fraction ≥ 50%, E/e′ 7.1 ± 1.5; median NT-proBNP 158 ng/L (IQR 82–298). Pearson’s correlation coefficient and multiple linear regression analyses, using sex and age as covariates, were used to describe associations of the O3I with metabolic phenotype, functional capacity, echocardiographic markers for LVDF, and neurohumoral activation at baseline/12 months. Results The O3I was below (< 8%), within (8–11%), and higher (> 11%) than the target range in 374 (93%), 29 (7%), and 1 (0.2%) patients, respectively. Mean O3I was 5.7 ± 1.7%. The O3I was inversely associated with HbA1c (r = − 0.139, p = 0.006), triglycerides-to-HDL-C ratio (r = − 0.12, p = 0.017), triglycerides (r = − 0.117, p = 0.02), non-HDL-C (r = − 0.101, p = 0.044), body-mass-index (r = − 0.149, p = 0.003), waist circumference (r = − 0.121, p = 0.015), waist-to-height ratio (r = − 0.141, p = 0.005), and positively associated with submaximal aerobic capacity (r = 0.113, p = 0.023) and LVEF (r = 0.211, p < 0.001) at baseline. Higher O3I at baseline was predictive of submaximal aerobic capacity (β = 15.614, p < 0,001), maximal aerobic capacity (β = 0.399, p = 0.005) and LVEF (β = 0.698, p = 0.007) at 12 months. Conclusions Higher O3I was associated with a more favorable cardiometabolic risk profile and predictive of higher submaximal/maximal aerobic capacity and lower BMI/truncal adiposity in HFpEF patients. Graphic abstract Omega-3 fatty acid blood levels are inversely associated with cardiometabolic risk factors in HFpEF patients. Higher O3I was associated with a more favorable cardiometabolic risk profile and aerobic capacity (left) but did not correlate with echocardiographic markers for left ventricular diastolic function or neurohumoral activation (right). An O3I-driven intervention trial might be warranted to answer the question whether O3-FA in therapeutic doses (with the target O3I 8–11%) impact on echocardiographic markers for left ventricular diastolic function and neurohumoral activation in patients with HFpEF. This figure contains modified images from Servier Medical Art (https://smart.servier.com) licensed by a Creative Commons Attribution 3.0 Unported License.

Download Full-text

Cycling Exercise Training Enhances Platelet Mitochondrial Bioenergetics in Patients with Peripheral Arterial Disease: A Randomized Controlled Trial

Thrombosis and Haemostasis ◽

10.1055/s-0040-1722191 ◽

2021 ◽

Author(s):

Tieh-Cheng Fu ◽

Ming-Lu Lin ◽

Chih-Chin Hsu ◽

Shu-Chun Huang ◽

Yu-Ting Lin ◽

...

Keyword(s):

Exercise Training ◽

Peripheral Arterial Disease ◽

Aerobic Capacity ◽

Short Form ◽

Arterial Disease ◽

Control Group ◽

Mitochondrial Bioenergetics ◽

Cycling Exercise ◽

Complex Ii ◽

Peripheral Arterial

AbstractExercise training influences the risk of vascular thrombosis in patients with peripheral arterial disease (PAD). Mitochondrial functionalities in platelets involve the cellular bioenergetics and thrombogenesis. This study aimed to elucidate the effect of cycling exercise training (CET) on platelet mitochondrial bioenergetics in PAD patients. Forty randomly selected patients with PAD engaged in general rehabilitation (GR) with CET (i.e., cycling exercise at ventilation threshold for 30 minute/day, 3 days/week) (GR + CET, n = 20) or to a control group that only received GR course (n = 20) for 12 weeks. Systemic aerobic capacity and platelet mitochondrial bioenergetics that included oxidative phosphorylation (OXPHOS) and electron transport system (ETS) were measured using automatic gas analysis and high-resolution respirometry, respectively. The experimental results demonstrated that GR + CET for 12 weeks significantly (1) elevated VO2peak and lowered VE-VCO2 slope, (2) raised resting ankle-brachial index and enhanced cardiac output response to exercise, (3) increased the distance in 6-minute walk test and raised the Short Form-36 physical/mental component scores, and (4) enhanced capacities of mitochondrial OXPHOS and ETS in platelets by activating FADH2 (complex II)-dependent pathway. Moreover, changes in VO2peak levels were positively associated with changes in platelet OXPHOS and ETS capacities. However, no significant changes in systemic aerobic capacity, platelet mitochondrial bioenergetics, and health-related quality of life (HRQoL) occurred following GR alone. Hence, we conclude that CET effectively increases the capacities of platelet mitochondrial bioenergetics by enhancing complex II activity in patients with PAD. Moreover, the exercise regimen also enhanced functional exercise capacity, consequently improving HRQoL in PAD patients.

Download Full-text

Relationship between Repeated Sprint Ability and Aerobic Capacity in Professional Soccer Players

The Scientific World JOURNAL ◽

10.1155/2013/952350 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5 ◽

Cited By ~ 6

Author(s):

Rhys M. Jones ◽

Christian C. Cook ◽

Liam P. Kilduff ◽

Zoran Milanović ◽

Nic James ◽

...

Keyword(s):

Aerobic Capacity ◽

Significant Negative Correlation ◽

Soccer Players ◽

Active Recovery ◽

Maximal Aerobic Capacity ◽

Sprint Time ◽

Repeated Sprint Ability ◽

Professional Soccer ◽

Repeated Sprint ◽

Sprint Ability

Aim. The aim of the present study was to investigate the relationship between maximal aerobic capacity () and repeated sprint ability (RSA) in a group of professional soccer players.Methods. Forty-one professional soccer players (age yrs, height cm, weight kg) were required to perform tests to assess RSA and on two separate days with at least 48 hr rest between testing sessions. Each player performed a treadmill test to determine their and a test for RSA involving the players completing m sprints (turn after 20 m) with 20 s active recovery between each sprint.Results. There was a significant negative correlation between body mass normalised and mean sprint time () (; ) and total sprint time () (, ).Conclusion. Results of the current study indicate that is one important factor aiding soccer players in the recovery from repeated sprint type activities.

Download Full-text