W02-P-004 Polyunsaturated fatty acids of marine origin induce mitochondrial biogenesis and beta-oxidation in white fat

2005 ◽  
Vol 6 (1) ◽  
pp. 8
Author(s):  
P. Flachs ◽  
O. Matejkova ◽  
P. Pecina ◽  
N. Frassen ◽  
P. Brauner ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Mitochondrial Biogenesis ◽  
Beta Oxidation ◽  
Marine Origin ◽  
White Fat

scholarly journals Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce β-oxidation in white fat

Diabetologia ◽  
2005 ◽  
Vol 48 (11) ◽  
pp. 2365-2375 ◽  
Author(s):  
P. Flachs ◽  
O. Horakova ◽  
P. Brauner ◽  
M. Rossmeisl ◽  
P. Pecina ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Mitochondrial Biogenesis ◽  
Marine Origin ◽  
White Fat

Structural Homogeneity in Unsaturated Fatty Acids of Marine Lipids. A Review

1964 ◽  
Vol 21 (2) ◽  
pp. 247-254 ◽  
Author(s):  
R. G. Ackman
Keyword(s):  
Fatty Acids ◽  
Double Bond ◽  
Polyunsaturated Fatty Acids ◽  
Chain Length ◽  
Unsaturated Fatty Acids ◽  
Analytical Data ◽  
Double Bonds ◽  
Marine Origin ◽  
Methyl Group ◽  
Marine Lipids

Consideration of recent analytical data supports the conclusion that the longer-chain polyunsaturated fatty acids of marine origin are all structurally homogeneous in that the double bonds are cis, the double bonds methylene interrupted, and that, with the exception of the C16 chain length, the ultimate double bond will normally be three, six or nine carbon atoms removed from the terminal methyl group.

scholarly journals Health aspects of fish and n-3 polyunsaturated fatty acids from plant and marine origin

1998 ◽  
Vol 52 (10) ◽  
pp. 749-753 ◽  
Author(s):  
EAM de Deckere ◽  
O Korver ◽  
PM Verschuren ◽  
MB Katan
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Marine Origin

scholarly journals N-3 Polyunsaturated Fatty Acids of Marine Origin and Multifocality in Human Breast Cancer

PLoS ONE ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. e0147148 ◽  
Author(s):  
Lobna Ouldamer ◽  
Caroline Goupille ◽  
Anne Vildé ◽  
Flavie Arbion ◽  
Gilles Body ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Marine Origin

Effects of a Diet Rich in n-3 Polyunsaturated Fatty Acids on Hepatic Lipogenesis and Beta-Oxidation in Mice

Lipids ◽  
2014 ◽  
Vol 49 (5) ◽  
pp. 431-444 ◽  
Author(s):  
Thereza C. Lonzetti Bargut ◽  
Eliete D. C. Frantz ◽  
Carlos A. Mandarim-de-Lacerda ◽  
Marcia Barbosa Aguila
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Hepatic Lipogenesis ◽  
Beta Oxidation

scholarly journals β-oxidation of polyunsaturated fatty acids with conjugated double bonds. Mitochondrial metabolism of octa-2,4,6-trienoic acid

1989 ◽  
Vol 264 (1) ◽  
pp. 47-52 ◽  
Author(s):  
H Y Wang ◽  
H Schulz
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Unsaturated Fatty Acids ◽  
Liver Mitochondria ◽  
Trienoic Acid ◽  
Rat Liver Mitochondria ◽  
Double Bonds ◽  
Beta Oxidation ◽  
Rat Heart Mitochondria ◽  
Coa Reductase

The mitochondrial beta-oxidation of octa-2,4,6-trienoic acid was studied with the aim of elucidating the degradation of unsaturated fatty acids with conjugated double bonds. Octa-2,4,6-trienoic acid was found to be a respiratory substrate of coupled rat liver mitochondria, but not of rat heart mitochondria. Octa-2,4,6-trienoyl-CoA, the product of the inner-mitochondrial activation of the acid, was chemically synthesized and its degradation by purified enzymes of beta-oxidation was studied spectrophotometrically and by use of h.p.l.c. This compound is a substrate of NADPH-dependent 2,4-dienoyl-CoA reductase or 4-enoyl-CoA reductase (EC 1.3.1.34), which facilitates its further beta-oxidation. The product obtained after the NADPH-dependent reduction of octa-2,4,6-trienoyl-CoA and one round of beta-oxidation was hex-4-enoyl-CoA, which can be completely degraded via beta-oxidation. It is concluded that polyunsaturated fatty acids with two conjugated double bonds extending from even-numbered carbon atoms can be completely degraded via beta-oxidation because their presumed 2,4,6-trienoyl-CoA intermediates are substrates of 2,4-dienoyl-CoA reductase.

scholarly journals Involvement of polyunsaturated fatty acids in the control of energy storage and expenditure

OCL ◽  
2019 ◽  
Vol 26 ◽  
pp. 37 ◽  
Author(s):  
Didier F. Pisani ◽  
Gérard Ailhaud
Keyword(s):  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Energy Expenditure ◽  
Polyunsaturated Fatty Acids ◽  
Energy Homeostasis ◽  
Daily Intake ◽  
Brown Adipose ◽  
Dietary Components ◽  
White Fat ◽  
The Impact

Within heterotrophic organisms, fat, sugar and protein are required to bring energy. In humans, energy homeostasis (i.e. the balance between energy intake and energy expenditure) is tightly regulated. Obesity, characterized by an excess of white fat mass, is a consequence of dysregulation of this balance in which decreased energy expenditure plays an important role. Among dietary components, fat represents approximately 30% of daily intake. Recent studies have shown that, besides its caloric input, fatty acid composition of fat represents an important qualitative issue. The impact of ω6 and ω3 polyunsaturated fatty acids on weight gain and development has been extensively studied. Interestingly, the role played by these polyunsaturated fatty acids in energy expenditure has been also characterized and will be discussed in relation to the various organs involved, in particular brown adipose tissue.

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