scholarly journals P218 Therapeutic inhibition of CatS reduces airway inflammation and mucus plugging but does not prevent the progression of lung tissue damage in adult βENaC-Tg mice

2019 ◽  
Vol 18 ◽  
pp. S118-S119
Author(s):  
R.R. Brown ◽  
D.M. Small ◽  
L. Holsinger ◽  
R. Booth ◽  
J.S. Elborn ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Lung Tissue ◽  
Tissue Damage ◽  
Lung Tissue Damage

scholarly journals Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Ryan Brown ◽  
Donna M. Small ◽  
Declan F. Doherty ◽  
Leslie Holsinger ◽  
Robert Booth ◽  
...  
Keyword(s):  
Lung Disease ◽  
Airway Inflammation ◽  
Lung Tissue ◽  
Tissue Damage ◽  
Cathepsin S ◽  
Na Channel ◽  
Chronic Obstructive ◽  
Tissue Destruction ◽  
Cell Counts ◽  
Lung Tissue Damage

Background. Elevated levels of the cysteine protease cathepsin S (CatS) are associated with chronic mucoobstructive lung diseases such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). We have previously demonstrated that prophylactic treatment with a CatS inhibitor from birth reduces inflammation, mucus plugging, and lung tissue damage in juvenile β-epithelial Na+ channel-overexpressing transgenic (βENaC-Tg) mice with chronic inflammatory mucoobstructive lung disease. In this study, we build upon this work to examine the effects of therapeutic intervention with a CatS inhibitor in adult βENaC-Tg mice with established disease. Methods. βENaC-Tg mice and wild-type (WT) littermates were treated with a CatS inhibitor from 4 to 6 weeks of age, and CatS-/-βENaC-Tg mice were analysed at 6 weeks of age. Bronchoalveolar lavage (BAL) fluid inflammatory cell counts were quantified, and lung tissue destruction and mucus obstruction were analysed histologically. Results. At 6 weeks of age, βENaC-Tg mice developed significant airway inflammation, lung tissue damage, and mucus plugging when compared to WT mice. CatS-/-βENaC-Tg mice and βENaC-Tg mice receiving inhibitor had significantly reduced airway mononuclear and polymorphonuclear (PMN) cell counts as well as mucus plugging. However, in contrast to CatS-/-βENaC-Tg mice, therapeutic inhibition of CatS in βENaC-Tg mice had no effect on established emphysema-like lung tissue damage. Conclusions. These results suggest that while early CatS targeting may be required to prevent the onset and progression of lung tissue damage, therapeutic CatS targeting effectively inhibited airway inflammation and mucus obstruction. These results indicate the important role CatS may play in the pathogenesis and progression of mucoobstructive lung disease.

Methods of early diagnostics of severe pneumonia in children

2020 ◽  
Vol 03 (04) ◽  
pp. 43-46
Author(s):  
Sabir Nurgalam Amiraliev ◽  
Keyword(s):  
Young Children ◽  
Key Words ◽  
Lung Tissue ◽  
Tissue Damage ◽  
Severe Pneumonia ◽  
Early Diagnostics ◽  
Key Words Pneumonia ◽  
Pneumonia Severity ◽  
Acute Pneumonia ◽  
Lung Tissue Damage

Studies have shown that the severity and outcome of acute pneumonia largely depends on the prevalence of the focus of inflammation in the lung tissue, which is determined radiologically. We analyzed and determined a statistically significant effect of the degree of lung tissue damage on the severity and prognosis of pneumonia in young children, taking into account the conditions of infection. In pneumonia, χ² = 47.13 (p <0.001), indicates that the greater the degree of damage, the greater the likelihood of a severe course and unfavorable outcome of pneumonia. Key words: pneumonia, severity of the course, outcome, young children

scholarly journals Pengaruh Pemberian Taurin terhadap Gambaran Histopatologi Paru Mencit (Mus musculus) yang Diinduksi Karsinogen Benzo(α)Piren secara In Vivo

2017 ◽  
Vol 17 (1) ◽  
pp. 22
Author(s):  
Arini Pradita Roselyn ◽  
Endang Linirin Widiastuti ◽  
G. Nugroho Susanto ◽  
Sutyarso '
Keyword(s):  
Lung Tissue ◽  
Mus Musculus ◽  
Tissue Damage ◽  
Corn Oil ◽  
Group Vi ◽  
Normal Tissues ◽  
Randomized Design ◽  
Group I ◽  
Lung Tissue Damage

Lung cancer is a disease that causes high mortality. Drugs used to prevent and cure cancer mostly causes intoxicity to the normal tissues due to its less effectiveness. Therefore, it is necessary to find out any agent or substance which works much more effective and safe for cancer treatment. The aim of the study was to elucidate the role of taurine on the lung tissue of mice (Mus musculus) induced by carcinogenic benzo(α)pyrene. The experiment was conducted in a completely randomized design with 5 replications. Six treatment groups were perfomed. Group I was given 0.2 mL of corn oil and given aquadest until the end of the study period, group II was induced by benzo(α)pyrene without administration of taurine, group III before induced with benzo(α)pyrene, was given taurine dosage 7.8 mg/BW/day for two weeks, group IV after induced benzo(α)pyrene, was given taurine with dosage 3.9 mg/BW/day, group V after induced benzo(α)pyrene, was given taurine with dosage7. 8 mg/BW/day, group VI after induced with benzo(α)pyrene, was given taurine with dosage 15.6 mg/BW/day. The results of the Kruskal-Wallis analysis and one way ANOVA with LSD (p>0,05) showed that taurine reduced lung tissue damage 72.73% due to the administration of benzo(α)pyrene of 0.3 mg/BW/day. In addition, the effective dose of taurine reduce lung tissue damage was 15.6 mg/BW/day.

Sodium Bis(Hydroxyethyl)dithiocarbamate Reduces Acute Lung Tissue Damage Induced by Cadmium in Rats

1991 ◽  
Vol 16 (4) ◽  
pp. 733-741
Author(s):  
VALDEMAR KOBRLE ◽  
JOSEF HURYCH ◽  
MIROSLAV CIKRT ◽  
MARK M. JONES
Keyword(s):  
Lung Tissue ◽  
Tissue Damage ◽  
Lung Tissue Damage

scholarly journals Decay-Accelerating Factor Mitigates Controlled Hemorrhage-Instigated Intestinal and Lung Tissue Damage and Hyperkalemia in Swine

2011 ◽  
Vol 71 (supplement) ◽  
pp. S151-S160 ◽  
Author(s):  
Jurandir J. Dalle Lucca ◽  
Milomir Simovic ◽  
Yansong Li ◽  
Chantal Moratz ◽  
Michael Falabella ◽  
...  
Keyword(s):  
Lung Tissue ◽  
Tissue Damage ◽  
Decay Accelerating Factor ◽  
Lung Tissue Damage

Clinical observation of a young patient with obesity and COVID-19-associated lung tissue damage

Therapy ◽  
2020 ◽  
Vol 8_2020 ◽  
pp. 156-161
Author(s):  
Larina V.N. Larina ◽  
Bondarenkova A.A. Bondarenkova ◽  
Keyword(s):  
Young Patient ◽  
Lung Tissue ◽  
Tissue Damage ◽  
Clinical Observation ◽  
Lung Tissue Damage
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