N49 RECURRENCE-FREE SURVIVAL IN PATIENTS WITH UROTHELIAL UPPER URINARY TRACT TUMORS (UUT) IN UKRAINE

2010 ◽  
Vol 9 (6) ◽  
pp. 546
Author(s):  
A.F. Vozianov ◽  
P.G. Yakovlev ◽  
V.S. Sakalo ◽  
V.V. Mrachkovskiy ◽  
G.P. Olijnichenko
Keyword(s):  
Urinary Tract ◽  
Upper Urinary Tract ◽  
Recurrence Free Survival ◽  
Free Survival

scholarly journals Predictive Value of Preoperative Positive Urine Cytology for Development of Bladder Cancer After Nephroureterectomy in Patients With Upper Urinary Tract Urothelial Carcinoma: A Prognostic Nomogram Based on a Retrospective Multicenter Cohort Study and Systematic Meta-Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Bo Fan ◽  
Yuanbin Huang ◽  
Shuang Wen ◽  
Qiliang Teng ◽  
Xinrui Yang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Urinary Tract ◽  
Meta Analysis ◽  
Upper Urinary Tract ◽  
Urine Cytology ◽  
Biological Behavior ◽  
Recurrence Free Survival ◽  
Free Survival ◽  
Positive Urine ◽  
Urinary Tract Urothelial Carcinoma

BackgroundUpper urinary tract urothelial carcinoma (UUT-UC) is a rare and severe urinary malignancy. Several studies have explored the relationship between preoperative urine cytology and intravesical recurrence (IVR) in patients with UUT-UC. However, the results of these studies are controversial or even contradictory, and investigations with UUT-UC patients in northeast China are rare.MethodsWe first estimated the prognostic significance of preoperative urine cytology in the outcomes of intravesical recurrence in 231 UUT-UC patients (training cohort = 142, validation cohort = 89) after radical nephroureterectomy (RNU) by the nomogram model. Subsequently, we quantitatively combined our results with the published data after searching several databases to assess whether preoperative positive urine cytology was associated with poor intravesical recurrence-free survival and a high risk of tumor malignant biological behavior.ResultsFirstly, the multicenter retrospective cohort study demonstrated that preoperative positive urine cytology correlated with poor intravesical recurrence-free survival and can serve as significant independent predictors of IVR by Kaplan–Meier curves and Cox regression analysis. The construction of the nomogram demonstrated that predictive efficacy and accuracy were significantly improved when preoperative urine cytology was combined. Meanwhile, meta-analysis showed that preoperative positive urine cytology was associated with a 49% increased risk of IVR. In the subgroup analysis by region, study type, and sample size, the pooled hazard ratios (HRs) were statistically significant for the Japan subgroup (HR 1.32), China subgroup (HR 1.88), cohort study subgroup (HR 1.45), and the single-arm study subgroup (HR 1.63).ConclusionsPreoperative urine cytology was validated as a potential predictor of intravesical recurrence in patients with UUT-UC after RNU, although these results need to be generalized with caution. Large, prospective trials are required to further confirm its significance in prognosis and tumor malignant biological behavior.

scholarly journals Does Xylinas’ nomogram accurately predict intravesical recurrence risk after radical nephroureterectomy for primary upper urinary tract urothelial carcinoma when applied to Asian populations?

2020 ◽  
Author(s):  
Shicong Lai ◽  
Pengjie Wu ◽  
Tongxiang Diao ◽  
Samuel Seery ◽  
Jianyong Liu ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
External Validation ◽  
Upper Urinary Tract ◽  
Recurrence Free Survival ◽  
Full Model ◽  
Radical Nephroureterectomy ◽  
Free Survival ◽  
Asian Populations ◽  
Urinary Tract Urothelial Carcinoma

Abstract Objective To validate a prognostic nomogram (Xylinas’ nomogram) for intravesical recurrence after radical nephroureterectomy for primary upper urinary tract urothelial carcinoma patients of Asian descent. Methods Clinicopathological and survival data from 243 primary urinary tract urothelial carcinoma patients who underwent radical nephroureterectomy with bladder cuff excision between January 2004 and May 2017 were collated. Univariate and multivariable Cox regression analyses were performed to identify independent risk factors associated with intravesical recurrence-free survival. External validation was determined using regression coefficients abstracted from previously published data. Performance was then quantified through calibration and discrimination, according to concordance indexes (c-index) in receiver operating characteristic curves. Results 163 patients met our eligibility criteria and were finally included in this study. At a median follow-up of 60 months, intravesical recurrence occurred in 29.4% (n = 48). Multivariable analysis revealed that being male, ureteral tumor location, tumor multifocality and previous bladder cancer were independent prognostic factors of intravesical recurrence-free survival. When Xylinas’ nomogram was applied to our cohort, the discriminatory power was found to be roughly equivalent with a c-index of 68.3% for the reduced model and 68.4% for the full model. Calibration plots also revealed intravesical recurrence predictions at 3, 6, 12, 18, 24 and 36 months had relative concordance. Contrasting the respective performances of the reduced and full model suggests there is no significant difference between the two (all P > 0.05). Conclusions This nomogram appears accurate at predicting intravesical recurrence after radical nephroureterectomy for primary urinary tract urothelial carcinoma in Asian populations. However, it remains necessary to data mine for unknown prognostic factors for optimization. Further external validation is required across larger, ethically diverse populations before applying this nomogram in clinical practice.

C131 RESULTS OF RECURRENCE FREE SURVIVAL IN PATIENTS WITH UPPER URINARY TRACT TUMORS

2010 ◽  
Vol 9 (6) ◽  
pp. 651
Author(s):  
V. Sakalo ◽  
P. Yakovlev ◽  
V. Mrachkovskiy ◽  
A. Kondratenko ◽  
V. Hrygorenko
Keyword(s):  
Urinary Tract ◽  
Upper Urinary Tract ◽  
Recurrence Free Survival ◽  
Free Survival

scholarly journals Comparison of oncologic and functional outcomes between radical nephroureterectomy and segmental ureterectomy for upper urinary tract urothelial carcinoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tae Heon Kim ◽  
Chung Un Lee ◽  
Minyong Kang ◽  
Hwang Gyun Jeon ◽  
Byong Chang Jeong ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Functional Outcomes ◽  
Upper Urinary Tract ◽  
Rank Test ◽  
Radical Nephroureterectomy ◽  
Free Survival ◽  
Significant Difference ◽  
Segmental Ureterectomy ◽  
Urinary Tract Urothelial Carcinoma

AbstractThis study aims to compare oncologic and functional outcomes after radical nephroureterectomy (RNU) and segmental ureterectomy (SU) in patients with upper urinary tract urothelial carcinoma (UTUC). We retrospectively collected data on patients who underwent either RNU or SU of UTUC. Propensity score matching was performed among 394 cases to yield a final cohort of 40 RNU and 40 SU cases. Kaplan–Meier analysis and the log-rank test were used to compare overall survival (OS), cancer-specific survival (CSS), progression-free survival (PFS), and intravesical recurrence-free survival (IVRFS) between the groups. We also compared the change in postoperative estimated glomerular filtration rate (eGFR). There was no significant difference in terms of CSS, PFS, and IVRFS between the RNU and SU groups, but the RNU group had a better OS than the SU group (p = 0.032). Postoperative eGFR was better preserved in the SU group than in the RNU group (p < 0.001). SU provides comparable CSS, PFS, and IVRFS for patients with UTUC compared to RNU, even in patients with advanced-stage and/or high-grade cancer. Further, SU achieves better preservation of renal function.

scholarly journals Long-term results of retroperitoneoscopic nephroureterectomy for upper urinary tract transitional cell carcinoma in China

2013 ◽  
Vol 7 (5-6) ◽  
pp. 287 ◽  
Author(s):  
Xiao-Qing Wang ◽  
Feng-Ming Jiang ◽  
Qi-Hui Chen ◽  
Yu-Chuan Hou ◽  
Hai-Feng Zhang ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Survival Rate ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Clinical Outcomes ◽  
Transitional Cell ◽  
Upper Urinary Tract ◽  
Free Survival ◽  
Node Metastasis

Objective: We compared long-term clinical outcomes of upperurinary tract transitional cell carcinoma (TCC) patients treated byretroperitoneoscopic nephroureterectomy (RNU) or open radicalnephroureterectomy (ONU).Methods: Upper urinary tract TCC patients were treated with RNU(n = 86) or ONU (n = 72) and followed-up for more than threeyears. Demographic and clinical data, including preoperativeindexes, intraoperative indexes and long-term clinical outcomes,were retrospectively compared to determine long-term efficacy ofthe two procedures.Results: The RNU and ONU groups were statistically similar inage, gender, previous bladder cancer history, tumour location,pathologic tumour stage, pathologic node metastasis or tumourpathologic grade. The original surgery time required for both RNUand ONU was statistically similar, but RNU was associated witha significantly smaller volume of intraoperative estimated bloodloss and shorter length of postoperative hospital stay. Follow-up(average: 42.4 months, range: 3-57) revealed that the RNU 3-yearrecurrence-free survival rate was 62.8% and the 3-year cancerspecific survival rate was 80.7%. In the ONU group, the 3-yearrecurrence-free survival and the three-year cancer-specific survivalrates were 59.2% and 80.3%, respectively. Neither of the survivalrates were statistically different between the two groups. T stage,grade, lymph node metastasis and bladder tumour history wererisk factors for tumour recurrence; the operation mode and thebladder cuff incision mode had no correlation with the recurrencefreesurvival.Conclusion: The open surgery strategy and the retroperitoneoscopicnephroureterectomy strategy are equally effective for treating upperurinary tract TCC. However, the RNU procedure is less invasive,and requires a shorter duration of postoperative hospitalized care;thus, RNU is recommended as the preferred strategy.

Prognostic significance of OXR1 in urothelial carcinoma: low OXR1 expression is associated with worse survival

2021 ◽  
Author(s):  
Chien-Cheng Lai ◽  
Tzu-Ju Chen ◽  
Ti-Chun Chan ◽  
Wan-Shan Li ◽  
Hong-Lin He
Keyword(s):  
Urinary Tract ◽  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Histological Grade ◽  
Prognostic Significance ◽  
Bioinformatic Analysis ◽  
Upper Urinary Tract ◽  
Free Survival ◽  
Muscle Invasive ◽  
Low Expression

Background: Bioinformatic analysis has revealed that OXR1 is significantly downregulated in muscle-invasive bladder cancer. Patients & methods: The expression of OXR1 in patients with urothelial carcinoma was evaluated by immunohistochemistry, including 340 cases with urothelial carcinoma in the upper urinary tract and 295 in the urinary bladder. Results: Low expression of OXR1 was significantly correlated with adverse pathological parameters including high primary tumor (pT) stage, high node stage, high histological grade, high mitotic activity and increased vascular or perineural invasion (all p < 0.05). Low expression of OXR1 independently predicted worse metastasis-free survival (p = 0.033) in urothelial carcinoma of the upper urinary tract and worse disease-specific survival (p = 0.022) and metastasis-free survival (p < 0.001) in urothelial carcinoma of the urinary bladder. Conclusion: Low expression of OXR1 is an adverse prognostic factor in urothelial carcinoma.

scholarly journals Developing a prediction model for disease‐free survival from upper urinary tract urothelial carcinoma in the Korean population

2019 ◽  
Vol 8 (11) ◽  
pp. 4967-4975
Author(s):  
Sung Han Kim ◽  
Mi Kyung Song ◽  
Bumsik Hong ◽  
Seok Ho Kang ◽  
Byong Chang Jeong ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Prediction Model ◽  
Urothelial Carcinoma ◽  
Disease Free Survival ◽  
Upper Urinary Tract ◽  
Korean Population ◽  
Free Survival ◽  
Disease Free ◽  
Urinary Tract Urothelial Carcinoma
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